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Kossiakoff, Anthony

One or more keywords matched the following items that are connected to Kossiakoff, Anthony

Item Type	Name
Concept	Protein Conformation
Academic Article	Variability of conformations at crystal contacts in BPTI represent true low-energy structures: correspondence among lattice packing and molecular dynamics structures.
Academic Article	Structural consequences of mutation.
Academic Article	Structural effects induced by mutagenesis affected by crystal packing factors: the structure of a 30-51 disulfide mutant of basic pancreatic trypsin inhibitor.
Academic Article	Hydroxyl and water molecule orientations in trypsin: comparison to molecular dynamic structures.
Academic Article	Crystallization and preliminary X-ray analysis of a 1:1 complex between a designed monomeric interferon-gamma and its soluble receptor.
Academic Article	Crystal structures of bovine chymotrypsin and trypsin complexed to the inhibitor domain of Alzheimer's amyloid beta-protein precursor (APPI) and basic pancreatic trypsin inhibitor (BPTI): engineering of inhibitors with altered specificities.
Academic Article	Crystallization of ovine placental lactogen in a 1:2 complex with the extracellular domain of the rat prolactin receptor.
Academic Article	X-ray structure of human relaxin at 1.5 A. Comparison to insulin and implications for receptor binding determinants.
Academic Article	Probing intermolecular backbone H-bonding in serine proteinase-protein inhibitor complexes.
Academic Article	Analysis of solvent structure in proteins using neutron D2O-H2O solvent maps: pattern of primary and secondary hydration of trypsin.
Academic Article	Structural basis for cytokine hormone-receptor recognition and receptor activation.
Academic Article	The functional binding epitope of a high affinity variant of human growth hormone mapped by shotgun alanine-scanning mutagenesis: insights into the mechanisms responsible for improved affinity.
Academic Article	Structural effects induced by removal of a disulfide-bridge: the X-ray structure of the C30A/C51A mutant of basic pancreatic trypsin inhibitor at 1.6 A.
Academic Article	Crystals of the complex between human growth hormone and the extracellular domain of its receptor.
Academic Article	Engineering subtilisin and its substrates for efficient ligation of peptide bonds in aqueous solution.
Academic Article	Structure of bistramide A-actin complex at a 1.35 angstroms resolution.
Academic Article	Dissecting the energetics of protein alpha-helix C-cap termination through chemical protein synthesis.
Academic Article	X-ray structure of snow flea antifreeze protein determined by racemic crystallization of synthetic protein enantiomers.
Academic Article	The high- and low-affinity receptor binding sites of growth hormone are allosterically coupled.
Academic Article	X-ray crystal structure of the protease inhibitor domain of Alzheimer's amyloid beta-protein precursor.
Academic Article	Time-controlled microfluidic seeding in nL-volume droplets to separate nucleation and growth stages of protein crystallization.
Academic Article	Mechanism of activation gating in the full-length KcsA K+ channel.
Academic Article	Hydroxyl hydrogen conformations in trypsin determined by the neutron diffraction solvent difference map method: relative importance of steric and electrostatic factors in defining hydrogen-bonding geometries.
Academic Article	Tertiary structure is a principal determinant to protein deamidation.
Academic Article	Total chemical synthesis and X-ray crystal structure of a protein diastereomer: [D-Gln 35]ubiquitin.
Academic Article	Structure of bovine trypsinogen at 1.9 A resolution.
Academic Article	Crystal structure of the kringle 2 domain of tissue plasminogen activator at 2.4-A resolution.
Academic Article	The X-ray structure of a growth hormone-prolactin receptor complex.
Academic Article	A method of solvent structure analysis for proteins using D2O-H2O neutron difference maps.
Academic Article	Use of the neutron diffraction--H/D exchange technique to determine the conformational dynamics of trypsin.
Academic Article	X-ray structures of the antigen-binding domains from three variants of humanized anti-p185HER2 antibody 4D5 and comparison with molecular modeling.
Academic Article	Allosteric control of ligand-binding affinity using engineered conformation-specific effector proteins.
Academic Article	Protein dynamics investigated by neutron diffraction.
Academic Article	Automated peak fitting procedure for processing data from an area detector and its application to the neutron structure of trypsin.
Academic Article	Neutron protein crystallography: advances in methods and applications.
Academic Article	Comparison of the intermediate complexes of human growth hormone bound to the human growth hormone and prolactin receptors.
Academic Article	Crystal structures of subtilisin BPN' variants containing disulfide bonds and cavities: concerted structural rearrangements induced by mutagenesis.
Academic Article	The production and X-ray structure determination of perdeuterated Staphylococcal nuclease.
Academic Article	Effect of protein packing structure on side-chain methyl rotor conformations.
Academic Article	Racemic crystallography of synthetic protein enantiomers used to determine the X-ray structure of plectasin by direct methods.
Academic Article	The use of neutrons to show how proteins work.
Academic Article	Direct determination of the protonation states of aspartic acid-102 and histidine-57 in the tetrahedral intermediate of the serine proteases: neutron structure of trypsin.
Academic Article	Mechanisms of zymogen activation.
Academic Article	Determination of the energetics governing the regulatory step in growth hormone-induced receptor homodimerization.
Academic Article	The crystal structure of a quercetin 2,3-dioxygenase from Bacillus subtilis suggests modulation of enzyme activity by a change in the metal ion at the active site(s).
Academic Article	Toward chaperone-assisted crystallography: protein engineering enhancement of crystal packing and X-ray phasing capabilities of a camelid single-domain antibody (VHH) scaffold.
Academic Article	The three-dimensional structure of Bacillus amyloliquefaciens subtilisin at 1.8 A and an analysis of the structural consequences of peroxide inactivation.
Academic Article	The application of neutron crystallography to the study of dynamic and and hydration properties of proteins.
Academic Article	Protein dynamics investigated by the neutron diffraction-hydrogen exchange technique.
Academic Article	Structure of active ß-arrestin-1 bound to a G-protein-coupled receptor phosphopeptide.
Academic Article	Conformational Chaperones for Structural Studies of Membrane Proteins Using Antibody Phage Display with Nanodiscs.
Academic Article	A polar ring endows improved specificity to an antibody fragment.
Academic Article	Specific Recognition of a Single-Stranded RNA Sequence by a Synthetic Antibody Fragment.
Academic Article	Engineered synthetic antibodies as probes to quantify the energetic contributions of ligand binding to conformational changes in proteins.
Academic Article	Locking the Elbow: Improved Antibody Fab Fragments as Chaperones for Structure Determination.
Academic Article	Ensemble cryoEM elucidates the mechanism of insulin capture and degradation by human insulin degrading enzyme.
Academic Article	An engineered ultra-high affinity Fab-Protein G pair enables a modular antibody platform with multifunctional capability.
Academic Article	Development of "Plug and Play" Fiducial Marks for Structural Studies of GPCR Signaling Complexes by Single-Particle Cryo-EM.
Academic Article	Synthetic antibodies against BRIL as universal fiducial marks for single-particle cryoEM structure determination of membrane proteins.
Academic Article	Structures of ABCB4 provide insight into phosphatidylcholine translocation.
Academic Article	Structure of an AMPK complex in an inactive, ATP-bound state.
Academic Article	Development of a universal nanobody-binding Fab module for fiducial-assisted cryo-EM studies of membrane proteins.
Academic Article	Architecture of the cytoplasmic face of the nuclear pore.
Concept	Protein Conformation, alpha-Helical
Concept	Protein Conformation, beta-Strand

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Protein Conformation