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Froelich, Christopher

One or more keywords matched the following items that are connected to Froelich, Christopher

Item Type	Name
Concept	Apoptosis
Concept	Apoptosis Regulatory Proteins
Concept	CASP8 and FADD-Like Apoptosis Regulating Protein
Academic Article	ICE-LAP6, a novel member of the ICE/Ced-3 gene family, is activated by the cytotoxic T cell protease granzyme B.
Academic Article	The CED-3/ICE-like protease Mch2 is activated during apoptosis and cleaves the death substrate lamin A.
Academic Article	The CD8+ granzyme B+ T-cell subset in peripheral blood from healthy individuals contains activated and apoptosis-prone cells.
Academic Article	New paradigm for lymphocyte granule-mediated cytotoxicity. Target cells bind and internalize granzyme B, but an endosomolytic agent is necessary for cytosolic delivery and subsequent apoptosis.
Academic Article	Lymphocyte granule-mediated apoptosis: matters of viral mimicry and deadly proteases.
Academic Article	Granzyme B independently of perforin mediates noncytolytic intracellular inactivation of vesicular stomatitis virus.
Academic Article	Granzyme B mimics apical caspases. Description of a unified pathway for trans-activation of executioner caspase-3 and -7.
Academic Article	Cytotoxic T-cell-derived granzyme B activates the apoptotic protease ICE-LAP3.
Academic Article	Granzyme B/perforin-mediated apoptosis of Jurkat cells results in cleavage of poly(ADP-ribose) polymerase to the 89-kDa apoptotic fragment and less abundant 64-kDa fragment.
Academic Article	Human perforin: rapid enrichment by immobilized metal affinity chromatography (IMAC) for whole cell cytotoxicity assays.
Academic Article	BCL-2 blocks perforin-induced nuclear translocation of granzymes concomitant with protection against the nuclear events of apoptosis.
Academic Article	Entry and trafficking of granzyme B in target cells during granzyme B-perforin-mediated apoptosis.
Academic Article	Pro-caspase-3 is a major physiologic target of caspase-8.
Academic Article	Perforin-dependent nuclear entry of granzyme B precedes apoptosis, and is not a consequence of nuclear membrane dysfunction.
Academic Article	HSV and glycoprotein J inhibit caspase activation and apoptosis induced by granzyme B or Fas.
Academic Article	Activation of a cysteine protease in MCF-7 and T47D breast cancer cells during beta-lapachone-mediated apoptosis.
Academic Article	Cytotoxic cell granule-mediated apoptosis: perforin delivers granzyme B-serglycin complexes into target cells without plasma membrane pore formation.
Academic Article	Cytosolic delivery of granzyme B by bacterial toxins: evidence that endosomal disruption, in addition to transmembrane pore formation, is an important function of perforin.
Academic Article	Cell death-associated translocation of plasma membrane components induced by CTL.
Academic Article	A distinct pathway of cell-mediated apoptosis initiated by granulysin.
Academic Article	Reconstitution of caspase 3 sensitizes MCF-7 breast cancer cells to doxorubicin- and etoposide-induced apoptosis.
Academic Article	Cytotoxic cell granule-mediated apoptosis. Characterization of the macromolecular complex of granzyme B with serglycin.
Academic Article	Granzyme B-mediated apoptosis--the elephant and the blind men?
Academic Article	Reconstitution of caspase-3 confers low glucose-enhanced tumor necrosis factor-related apoptosis-inducing ligand cytotoxicity and Akt cleavage.
Academic Article	Perforin and granzyme B induce apoptosis in FasL-resistant colon carcinoma cells.
Academic Article	The T cell death knell: immune-mediated tumor death in renal cell carcinoma.
Academic Article	A role for the granzyme B inhibitor serine protease inhibitor 6 in CD8+ memory cell homeostasis.
Academic Article	A clathrin/dynamin- and mannose-6-phosphate receptor-independent pathway for granzyme B-induced cell death.
Academic Article	Granzyme B activates procaspase-3 which signals a mitochondrial amplification loop for maximal apoptosis.
Academic Article	Granzyme-mediated cytotoxicity does not involve the mannose 6-phosphate receptors on target cells.
Academic Article	Granzyme A is a proinflammatory protease.
Academic Article	A novel mechanism for protein delivery: granzyme B undergoes electrostatic exchange from serglycin to target cells.
Academic Article	Perforin rapidly induces plasma membrane phospholipid flip-flop.
Academic Article	Granzyme B-induced and caspase 3-dependent cleavage of gelsolin by mouse cytotoxic T cells modifies cytoskeleton dynamics.
Academic Article	Granule-mediated killing: pathways for granzyme B-initiated apoptosis.
Academic Article	FLIP prevents apoptosis induced by death receptors but not by perforin/granzyme B, chemotherapeutic drugs, and gamma irradiation.
Academic Article	Apoptosis induced by granzyme B-glycosaminoglycan complexes: implications for granule-mediated apoptosis in vivo.
Academic Article	Hepatic natural killer cells exclusively kill splenic/blood natural killer-resistant tumor cells by the perforin/granzyme pathway.
Academic Article	Cytotoxic granule-mediated apoptosis: unraveling the complex mechanism.
Academic Article	Right place, right time.
Academic Article	Degradation of Mcl-1 by granzyme B: implications for Bim-mediated mitochondrial apoptotic events.
Academic Article	Mcl-1 is a key regulator of apoptosis resistance in Chlamydia trachomatis-infected cells.
Academic Article	Perforin oligomers form arcs in cellular membranes: a locus for intracellular delivery of granzymes.
Academic Article	Mouse cytotoxic T cell-derived granzyme B activates the mitochondrial cell death pathway in a Bim-dependent fashion.
Grant	Molecular Mechanism of Granule-mediated Apoptosis

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Apoptosis