Item Type | Name |
Concept
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Cell Membrane Permeability
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Concept
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Cell Membrane
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Concept
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Membrane Glycoproteins
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Concept
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Membrane Proteins
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Concept
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Membrane Lipids
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Concept
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Intracellular Membranes
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Concept
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Synovial Membrane
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Concept
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Complement Membrane Attack Complex
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Concept
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Membrane Potentials
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Concept
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Membrane Microdomains
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Concept
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Membrane Potential, Mitochondrial
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Academic Article
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Lymphocyte granule-mediated apoptosis: matters of viral mimicry and deadly proteases.
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Academic Article
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An antimicrobial activity of cytolytic T cells mediated by granulysin.
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Academic Article
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Granzyme B independently of perforin mediates noncytolytic intracellular inactivation of vesicular stomatitis virus.
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Academic Article
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Granzyme B/perforin-mediated apoptosis of Jurkat cells results in cleavage of poly(ADP-ribose) polymerase to the 89-kDa apoptotic fragment and less abundant 64-kDa fragment.
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Academic Article
|
Human perforin: rapid enrichment by immobilized metal affinity chromatography (IMAC) for whole cell cytotoxicity assays.
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Academic Article
|
Nuclear targeting of the serine protease granzyme A (fragmentin-1).
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Academic Article
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BCL-2 blocks perforin-induced nuclear translocation of granzymes concomitant with protection against the nuclear events of apoptosis.
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Academic Article
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P-glycoprotein does not protect cells against cytolysis induced by pore-forming proteins.
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Academic Article
|
Purification and use of granzyme B.
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Academic Article
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Entry and trafficking of granzyme B in target cells during granzyme B-perforin-mediated apoptosis.
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Academic Article
|
Perforin-dependent nuclear entry of granzyme B precedes apoptosis, and is not a consequence of nuclear membrane dysfunction.
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Academic Article
|
Cytotoxic cell granule-mediated apoptosis: perforin delivers granzyme B-serglycin complexes into target cells without plasma membrane pore formation.
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Academic Article
|
Cytosolic delivery of granzyme B by bacterial toxins: evidence that endosomal disruption, in addition to transmembrane pore formation, is an important function of perforin.
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Academic Article
|
Cell death-associated translocation of plasma membrane components induced by CTL.
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Academic Article
|
Flow cytometry cannot assess surface binding of perforin to target cells.
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Academic Article
|
A distinct pathway of cell-mediated apoptosis initiated by granulysin.
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Academic Article
|
The human cytomegalovirus protein UL16 mediates increased resistance to natural killer cell cytotoxicity through resistance to cytolytic proteins.
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Academic Article
|
Perforin and granzyme B induce apoptosis in FasL-resistant colon carcinoma cells.
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Academic Article
|
SPI-CI and SPI-6 cooperate in the protection from effector cell-mediated cytotoxicity.
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Academic Article
|
The T cell death knell: immune-mediated tumor death in renal cell carcinoma.
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Academic Article
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A role for the granzyme B inhibitor serine protease inhibitor 6 in CD8+ memory cell homeostasis.
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Academic Article
|
Myeloma cells are highly sensitive to the granule exocytosis pathway mediated by WT1-specific cytotoxic T lymphocytes.
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Academic Article
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Human neutrophils lack granzyme A, granzyme B, and perforin.
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Academic Article
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A clathrin/dynamin- and mannose-6-phosphate receptor-independent pathway for granzyme B-induced cell death.
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Academic Article
|
Granzyme B activates procaspase-3 which signals a mitochondrial amplification loop for maximal apoptosis.
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Academic Article
|
Detection of functional cell surface perforin by flow cytometry.
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Academic Article
|
Granzyme B translocates across the lipid membrane only in the presence of lytic agents.
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Academic Article
|
Perforin activity at membranes leads to invaginations and vesicle formation.
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Academic Article
|
Modulation of the tumor cell phenotype by IFN-gamma results in resistance of uveal melanoma cells to granule-mediated lysis by cytotoxic lymphocytes.
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Academic Article
|
A novel mechanism for protein delivery: granzyme B undergoes electrostatic exchange from serglycin to target cells.
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Academic Article
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Detection of human perforin by ELISpot and ELISA: ex vivo identification of virus-specific cells.
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Academic Article
|
Human perforin permeabilizing activity, but not binding to lipid membranes, is affected by pH.
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Academic Article
|
Perforin rapidly induces plasma membrane phospholipid flip-flop.
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Academic Article
|
FLIP prevents apoptosis induced by death receptors but not by perforin/granzyme B, chemotherapeutic drugs, and gamma irradiation.
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Academic Article
|
Human granzyme B mediates cartilage proteoglycan degradation and is expressed at the invasive front of the synovium in rheumatoid arthritis.
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Academic Article
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Hepatic natural killer cells exclusively kill splenic/blood natural killer-resistant tumor cells by the perforin/granzyme pathway.
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Academic Article
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Cytotoxic granule-mediated apoptosis: unraveling the complex mechanism.
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Academic Article
|
Right place, right time.
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Academic Article
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Degradation of Mcl-1 by granzyme B: implications for Bim-mediated mitochondrial apoptotic events.
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Academic Article
|
Deregulation of mitochondrial membrane potential by mitochondrial insertion of granzyme B and direct Hax-1 cleavage.
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Academic Article
|
Human perforin employs different avenues to damage membranes.
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Academic Article
|
Effects of MACPF/CDC proteins on lipid membranes.
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Academic Article
|
Membrane pore formation at protein-lipid interfaces.
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Academic Article
|
Perforin oligomers form arcs in cellular membranes: a locus for intracellular delivery of granzymes.
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Academic Article
|
Mouse cytotoxic T cell-derived granzyme B activates the mitochondrial cell death pathway in a Bim-dependent fashion.
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Grant
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Molecular Mechanism of Granule-mediated Apoptosis
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