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Letter to the Editor from Idrees and Bianco: "Treatment of Thyroid Dysfunction and Serum Lipids: A Systematic Review and Meta-analysis".
MISSING DATA IMPUTATION IN THE ELECTRONIC HEALTH RECORD USING DEEPLY LEARNED AUTOENCODERS.
Thalidomide: Rebirth of a Gestational Antiemetic?
Assessment of driving performance in patients with retinitis pigmentosa.
An Open Letter to the Food and Drug Administration Regarding the Use of Morcellation Procedures in Women Having Surgery for Presumed Uterine Myomas.
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Froelich, Christopher
One or more keywords matched the following items that are connected to
Froelich, Christopher
Item Type
Name
Concept
Perforin
Academic Article
Lymphocyte granule-mediated apoptosis: matters of viral mimicry and deadly proteases.
Academic Article
An antimicrobial activity of cytolytic T cells mediated by granulysin.
Academic Article
Granzyme B independently of perforin mediates noncytolytic intracellular inactivation of vesicular stomatitis virus.
Academic Article
Granzyme B/perforin-mediated apoptosis of Jurkat cells results in cleavage of poly(ADP-ribose) polymerase to the 89-kDa apoptotic fragment and less abundant 64-kDa fragment.
Academic Article
Human perforin: rapid enrichment by immobilized metal affinity chromatography (IMAC) for whole cell cytotoxicity assays.
Academic Article
Nuclear targeting of the serine protease granzyme A (fragmentin-1).
Academic Article
BCL-2 blocks perforin-induced nuclear translocation of granzymes concomitant with protection against the nuclear events of apoptosis.
Academic Article
P-glycoprotein does not protect cells against cytolysis induced by pore-forming proteins.
Academic Article
Purification and use of granzyme B.
Academic Article
Entry and trafficking of granzyme B in target cells during granzyme B-perforin-mediated apoptosis.
Academic Article
Perforin-dependent nuclear entry of granzyme B precedes apoptosis, and is not a consequence of nuclear membrane dysfunction.
Academic Article
Cytotoxic cell granule-mediated apoptosis: perforin delivers granzyme B-serglycin complexes into target cells without plasma membrane pore formation.
Academic Article
Cytosolic delivery of granzyme B by bacterial toxins: evidence that endosomal disruption, in addition to transmembrane pore formation, is an important function of perforin.
Academic Article
Flow cytometry cannot assess surface binding of perforin to target cells.
Academic Article
The human cytomegalovirus protein UL16 mediates increased resistance to natural killer cell cytotoxicity through resistance to cytolytic proteins.
Academic Article
Perforin and granzyme B induce apoptosis in FasL-resistant colon carcinoma cells.
Academic Article
The T cell death knell: immune-mediated tumor death in renal cell carcinoma.
Academic Article
Myeloma cells are highly sensitive to the granule exocytosis pathway mediated by WT1-specific cytotoxic T lymphocytes.
Academic Article
Human neutrophils lack granzyme A, granzyme B, and perforin.
Academic Article
A clathrin/dynamin- and mannose-6-phosphate receptor-independent pathway for granzyme B-induced cell death.
Academic Article
Detection of functional cell surface perforin by flow cytometry.
Academic Article
Granzyme B translocates across the lipid membrane only in the presence of lytic agents.
Academic Article
Granule-associated serine proteases: granzymes might not just be killer proteases.
Academic Article
Intracellular trafficking of perforin: to thwart a killer.
Academic Article
NK cell protease granzyme M targets alpha-tubulin and disorganizes the microtubule network.
Academic Article
Perforin activity at membranes leads to invaginations and vesicle formation.
Academic Article
Modulation of the tumor cell phenotype by IFN-gamma results in resistance of uveal melanoma cells to granule-mediated lysis by cytotoxic lymphocytes.
Academic Article
Detection of human perforin by ELISpot and ELISA: ex vivo identification of virus-specific cells.
Academic Article
Human and mouse granzyme A induce a proinflammatory cytokine response.
Academic Article
Human perforin permeabilizing activity, but not binding to lipid membranes, is affected by pH.
Academic Article
Perforin rapidly induces plasma membrane phospholipid flip-flop.
Academic Article
FLIP prevents apoptosis induced by death receptors but not by perforin/granzyme B, chemotherapeutic drugs, and gamma irradiation.
Academic Article
Hepatic natural killer cells exclusively kill splenic/blood natural killer-resistant tumor cells by the perforin/granzyme pathway.
Academic Article
Cytotoxic granule-mediated apoptosis: unraveling the complex mechanism.
Academic Article
Human perforin employs different avenues to damage membranes.
Academic Article
Effects of MACPF/CDC proteins on lipid membranes.
Academic Article
Perforin oligomers form arcs in cellular membranes: a locus for intracellular delivery of granzymes.
Academic Article
Pit cells exclusively kill P815 tumor cells by the perforin/granzyme pathway.
Grant
Molecular Mechanism of Granule-mediated Apoptosis
Search Criteria
Perforin