Connection | Profiles RNS

Search Result Details

Back to Search Results

This page shows the details of why an item matched the keywords from your search.

Search Results

Froelich, Christopher

One or more keywords matched the following items that are connected to Froelich, Christopher

Item Type	Name
Concept	Perforin
Academic Article	Lymphocyte granule-mediated apoptosis: matters of viral mimicry and deadly proteases.
Academic Article	An antimicrobial activity of cytolytic T cells mediated by granulysin.
Academic Article	Granzyme B independently of perforin mediates noncytolytic intracellular inactivation of vesicular stomatitis virus.
Academic Article	Granzyme B/perforin-mediated apoptosis of Jurkat cells results in cleavage of poly(ADP-ribose) polymerase to the 89-kDa apoptotic fragment and less abundant 64-kDa fragment.
Academic Article	Human perforin: rapid enrichment by immobilized metal affinity chromatography (IMAC) for whole cell cytotoxicity assays.
Academic Article	Nuclear targeting of the serine protease granzyme A (fragmentin-1).
Academic Article	BCL-2 blocks perforin-induced nuclear translocation of granzymes concomitant with protection against the nuclear events of apoptosis.
Academic Article	P-glycoprotein does not protect cells against cytolysis induced by pore-forming proteins.
Academic Article	Purification and use of granzyme B.
Academic Article	Entry and trafficking of granzyme B in target cells during granzyme B-perforin-mediated apoptosis.
Academic Article	Perforin-dependent nuclear entry of granzyme B precedes apoptosis, and is not a consequence of nuclear membrane dysfunction.
Academic Article	Cytotoxic cell granule-mediated apoptosis: perforin delivers granzyme B-serglycin complexes into target cells without plasma membrane pore formation.
Academic Article	Cytosolic delivery of granzyme B by bacterial toxins: evidence that endosomal disruption, in addition to transmembrane pore formation, is an important function of perforin.
Academic Article	Flow cytometry cannot assess surface binding of perforin to target cells.
Academic Article	The human cytomegalovirus protein UL16 mediates increased resistance to natural killer cell cytotoxicity through resistance to cytolytic proteins.
Academic Article	Perforin and granzyme B induce apoptosis in FasL-resistant colon carcinoma cells.
Academic Article	The T cell death knell: immune-mediated tumor death in renal cell carcinoma.
Academic Article	Myeloma cells are highly sensitive to the granule exocytosis pathway mediated by WT1-specific cytotoxic T lymphocytes.
Academic Article	Human neutrophils lack granzyme A, granzyme B, and perforin.
Academic Article	A clathrin/dynamin- and mannose-6-phosphate receptor-independent pathway for granzyme B-induced cell death.
Academic Article	Detection of functional cell surface perforin by flow cytometry.
Academic Article	Granzyme B translocates across the lipid membrane only in the presence of lytic agents.
Academic Article	Granule-associated serine proteases: granzymes might not just be killer proteases.
Academic Article	Intracellular trafficking of perforin: to thwart a killer.
Academic Article	NK cell protease granzyme M targets alpha-tubulin and disorganizes the microtubule network.
Academic Article	Perforin activity at membranes leads to invaginations and vesicle formation.
Academic Article	Modulation of the tumor cell phenotype by IFN-gamma results in resistance of uveal melanoma cells to granule-mediated lysis by cytotoxic lymphocytes.
Academic Article	Detection of human perforin by ELISpot and ELISA: ex vivo identification of virus-specific cells.
Academic Article	Human and mouse granzyme A induce a proinflammatory cytokine response.
Academic Article	Human perforin permeabilizing activity, but not binding to lipid membranes, is affected by pH.
Academic Article	Perforin rapidly induces plasma membrane phospholipid flip-flop.
Academic Article	FLIP prevents apoptosis induced by death receptors but not by perforin/granzyme B, chemotherapeutic drugs, and gamma irradiation.
Academic Article	Hepatic natural killer cells exclusively kill splenic/blood natural killer-resistant tumor cells by the perforin/granzyme pathway.
Academic Article	Cytotoxic granule-mediated apoptosis: unraveling the complex mechanism.
Academic Article	Human perforin employs different avenues to damage membranes.
Academic Article	Effects of MACPF/CDC proteins on lipid membranes.
Academic Article	Perforin oligomers form arcs in cellular membranes: a locus for intracellular delivery of granzymes.
Academic Article	Pit cells exclusively kill P815 tumor cells by the perforin/granzyme pathway.
Grant	Molecular Mechanism of Granule-mediated Apoptosis

Search Criteria

Perforin