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Concept
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Serine Proteinase Inhibitors
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Concept
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Serine Endopeptidases
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Academic Article
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ICE-LAP6, a novel member of the ICE/Ced-3 gene family, is activated by the cytotoxic T cell protease granzyme B.
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Academic Article
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Extracellular activities of human granzymes. I. Granzyme A induces IL6 and IL8 production in fibroblast and epithelial cell lines.
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Academic Article
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The CD8+ granzyme B+ T-cell subset in peripheral blood from healthy individuals contains activated and apoptosis-prone cells.
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Academic Article
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New paradigm for lymphocyte granule-mediated cytotoxicity. Target cells bind and internalize granzyme B, but an endosomolytic agent is necessary for cytosolic delivery and subsequent apoptosis.
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Academic Article
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Lymphocyte granule-mediated apoptosis: matters of viral mimicry and deadly proteases.
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Academic Article
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Synthesis and evaluation of diphenyl phosphonate esters as inhibitors of the trypsin-like granzymes A and K and mast cell tryptase.
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Academic Article
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Granzyme B independently of perforin mediates noncytolytic intracellular inactivation of vesicular stomatitis virus.
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Academic Article
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Granzyme B mimics apical caspases. Description of a unified pathway for trans-activation of executioner caspase-3 and -7.
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Academic Article
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Cytotoxic T-cell-derived granzyme B activates the apoptotic protease ICE-LAP3.
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Academic Article
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Granzyme B/perforin-mediated apoptosis of Jurkat cells results in cleavage of poly(ADP-ribose) polymerase to the 89-kDa apoptotic fragment and less abundant 64-kDa fragment.
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Academic Article
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Nuclear targeting of the serine protease granzyme A (fragmentin-1).
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Academic Article
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BCL-2 blocks perforin-induced nuclear translocation of granzymes concomitant with protection against the nuclear events of apoptosis.
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Academic Article
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The levels of soluble granzyme A and B are elevated in plasma and synovial fluid of patients with rheumatoid arthritis (RA).
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Academic Article
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Extracellular granzyme A, complexed to proteoglycans, is protected against inactivation by protease inhibitors.
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Academic Article
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Purification and use of granzyme B.
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Academic Article
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Entry and trafficking of granzyme B in target cells during granzyme B-perforin-mediated apoptosis.
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Academic Article
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Pro-caspase-3 is a major physiologic target of caspase-8.
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Academic Article
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Perforin-dependent nuclear entry of granzyme B precedes apoptosis, and is not a consequence of nuclear membrane dysfunction.
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Academic Article
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Extracellular granzymes A and B in humans: detection of native species during CTL responses in vitro and in vivo.
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Academic Article
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HSV and glycoprotein J inhibit caspase activation and apoptosis induced by granzyme B or Fas.
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Academic Article
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Cytotoxic cell granule-mediated apoptosis: perforin delivers granzyme B-serglycin complexes into target cells without plasma membrane pore formation.
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Academic Article
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Cytosolic delivery of granzyme B by bacterial toxins: evidence that endosomal disruption, in addition to transmembrane pore formation, is an important function of perforin.
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Academic Article
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HIV virions and HIV infection in vitro are unaffected by human granzymes A and B.
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Academic Article
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NF-kappaB protects from the lysosomal pathway of cell death.
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Academic Article
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Cytotoxic cell granule-mediated apoptosis. Characterization of the macromolecular complex of granzyme B with serglycin.
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Academic Article
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Lack of the CD8+ cell anti-HIV factor in CD8+ cell granules.
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Academic Article
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The human cytomegalovirus protein UL16 mediates increased resistance to natural killer cell cytotoxicity through resistance to cytolytic proteins.
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Academic Article
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Granzyme B-mediated apoptosis--the elephant and the blind men?
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Academic Article
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Reconstitution of caspase-3 confers low glucose-enhanced tumor necrosis factor-related apoptosis-inducing ligand cytotoxicity and Akt cleavage.
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Academic Article
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Perforin and granzyme B induce apoptosis in FasL-resistant colon carcinoma cells.
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Academic Article
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SPI-CI and SPI-6 cooperate in the protection from effector cell-mediated cytotoxicity.
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Academic Article
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The T cell death knell: immune-mediated tumor death in renal cell carcinoma.
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Academic Article
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A role for the granzyme B inhibitor serine protease inhibitor 6 in CD8+ memory cell homeostasis.
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Academic Article
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Human neutrophils lack granzyme A, granzyme B, and perforin.
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Academic Article
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A clathrin/dynamin- and mannose-6-phosphate receptor-independent pathway for granzyme B-induced cell death.
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Academic Article
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Granzyme B activates procaspase-3 which signals a mitochondrial amplification loop for maximal apoptosis.
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Academic Article
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Granzyme-mediated cytotoxicity does not involve the mannose 6-phosphate receptors on target cells.
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Academic Article
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Granule-associated serine proteases: granzymes might not just be killer proteases.
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Academic Article
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Extracellular matrix remodeling by human granzyme B via cleavage of vitronectin, fibronectin, and laminin.
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Academic Article
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A novel mechanism for protein delivery: granzyme B undergoes electrostatic exchange from serglycin to target cells.
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Academic Article
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Human granzyme B degrades aggrecan proteoglycan in matrix synthesized by chondrocytes.
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Academic Article
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Dominant chymotrypsin-like esterase activity in human lymphocyte granules is mediated by the serine carboxypeptidase called cathepsin A-like protective protein.
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Academic Article
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Serine and cysteine proteases are translocated to similar extents upon formation of covalent complexes with serpins. Fluorescence perturbation and fluorescence resonance energy transfer mapping of the protease binding site in CrmA complexes with granzyme B and caspase-1.
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Academic Article
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Human granzyme B is essential for DNA fragmentation of susceptible target cells.
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Academic Article
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Extracellular activities of human granzyme A. Monocyte activation by granzyme A versus alpha-thrombin.
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Academic Article
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Granule-mediated killing: pathways for granzyme B-initiated apoptosis.
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Academic Article
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FLIP prevents apoptosis induced by death receptors but not by perforin/granzyme B, chemotherapeutic drugs, and gamma irradiation.
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Academic Article
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Apoptosis induced by granzyme B-glycosaminoglycan complexes: implications for granule-mediated apoptosis in vivo.
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Academic Article
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Human granzyme B mediates cartilage proteoglycan degradation and is expressed at the invasive front of the synovium in rheumatoid arthritis.
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Academic Article
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Hepatic natural killer cells exclusively kill splenic/blood natural killer-resistant tumor cells by the perforin/granzyme pathway.
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Academic Article
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Cytotoxic granule-mediated apoptosis: unraveling the complex mechanism.
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Academic Article
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Degradation of Mcl-1 by granzyme B: implications for Bim-mediated mitochondrial apoptotic events.
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Academic Article
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Rapid purification of cationic granule proteases: application to human granzymes.
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Grant
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Molecular Mechanism of Granule-mediated Apoptosis
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