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Labro, Alain

One or more keywords matched the following items that are connected to Labro, Alain

Item Type	Name
Concept	Potassium Channels
Concept	Potassium Channel Blockers
Concept	Shaker Superfamily of Potassium Channels
Concept	Ether-A-Go-Go Potassium Channels
Concept	Potassium Channels, Inwardly Rectifying
Concept	KCNQ1 Potassium Channel
Concept	Kv1.2 Potassium Channel
Concept	Shaw Potassium Channels
Concept	Potassium Channels, Voltage-Gated
Concept	Kv1.5 Potassium Channel
Concept	Shab Potassium Channels
Academic Article	Gating of shaker-type channels requires the flexibility of S6 caused by prolines.
Academic Article	Coupling of voltage sensing to channel opening reflects intrasubunit interactions in kv channels.
Academic Article	Modulation of HERG gating by a charge cluster in the N-terminal proximal domain.
Academic Article	Role of the S6 C-terminus in KCNQ1 channel gating.
Academic Article	A polyether biotoxin binding site on the lipid-exposed face of the pore domain of Kv channels revealed by the marine toxin gambierol.
Academic Article	Conserved negative charges in the N-terminal tetramerization domain mediate efficient assembly of Kv2.1 and Kv2.1/Kv6.4 channels.
Academic Article	KCNQ1 channels voltage dependence through a voltage-dependent binding of the S4-S5 linker to the pore domain.
Academic Article	The electrically silent Kv6.4 subunit confers hyperpolarized gating charge movement in Kv2.1/Kv6.4 heterotetrameric channels.
Academic Article	Quantitative single-cell ion-channel gene expression profiling through an improved qRT-PCR technique combined with whole cell patch clamp.
Academic Article	Kv channel gating requires a compatible S4-S5 linker and bottom part of S6, constrained by non-interacting residues.
Academic Article	Phosphatidylinositol-4,5-bisphosphate (PIP(2)) stabilizes the open pore conformation of the Kv11.1 (hERG) channel.
Academic Article	The S4-S5 linker of KCNQ1 channels forms a structural scaffold with the S6 segment controlling gate closure.
Academic Article	A Kv channel with an altered activation gate sequence displays both "fast" and "slow" activation kinetics.
Academic Article	Dual effect of phosphatidylinositol (4,5)-bisphosphate PIP(2) on Shaker K(+) [corrected] channels.
Academic Article	Molecular mechanism for depolarization-induced modulation of Kv channel closure.
Academic Article	The rate-dependent biophysical properties of the LQT1 H258R mutant are counteracted by a dominant negative effect on channel trafficking.
Academic Article	Properties of deactivation gating currents in Shaker channels.
Academic Article	The ladder-shaped polyether toxin gambierol anchors the gating machinery of Kv3.1 channels in the resting state.
Academic Article	Mutations in the S6 gate isolate a late step in the activation pathway and reduce 4-AP sensitivity in shaker K(v) channel.
Academic Article	Modulation of Closed-State Inactivation in Kv2.1/Kv6.4 Heterotetramers as Mechanism for 4-AP Induced Potentiation.
Academic Article	Alkanols inhibit voltage-gated K(+) channels via a distinct gating modifying mechanism that prevents gate opening.
Academic Article	Kv3.1 uses a timely resurgent K(+) current to secure action potential repolarization.
Academic Article	Voltage-sensor conformation shapes the intra-membrane drug binding site that determines gambierol affinity in Kv channels.
Academic Article	Gambierol and n-alkanols inhibit Shaker Kv channel via distinct binding sites outside the K(+) pore.
Academic Article	Dromedary immune response and specific Kv2.1 antibody generation using a specific immunization approach.
Academic Article	Inverted allosteric coupling between activation and inactivation gates in K+ channels.
Academic Article	Determining the correct stoichiometry of Kv2.1/Kv6.4 heterotetramers, functional in multiple stoichiometrical configurations.
Academic Article	The Selectivity Filter Is Involved in the U-Type Inactivation Process of Kv2.1 and Kv3.1 Channels.
Academic Article	Impaired cytoplasmic domain interactions cause co-assembly defect and loss of function in the p.Glu293Lys KNCJ2 variant isolated from an Andersen-Tawil syndrome patient.
Academic Article	The resting membrane potential of hSC-CM in a syncytium is more hyperpolarised than that of isolated cells.
Academic Article	Molecular autopsy and subsequent functional analysis reveal de novo DSG2 mutation as cause of sudden death.
Academic Article	The nonconducting W434F mutant adopts upon membrane depolarization an inactivated-like state that differs from wild-type Shaker-IR potassium channels.
Academic Article	Clinical and functional characterisation of a recurrent KCNQ1 variant in the Belgian population.
Concept	ERG1 Potassium Channel
Academic Article	Immunosuppressive effects of new thiophene-based KV1.3 inhibitors.

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Potassium Channels