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Huo, Dezheng
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overview Dr. Huo’s research interests focus on the genetic, molecular, and environmental factors underlying etiology, prognosis, and treatment of cancers, particularly as they relate to cancer in underserved populations. His research spans across several areas of cancer epidemiology and clinical epidemiology, including: 1. Genetic epidemiology of breast cancer, particular in women of African ancestry with the use of genome-wide association and whole genome sequencing approach. 2. Environmental and lifestyle factors for breast cancer etiology in African women and risk prediction model building, and strategy for cancer screening. 3. Health disparity in breast cancer outcomes in multiethnic patient cohort study with multi-dimensional data. 4. Investigation of the utilization and effectiveness of cancer treatment in real world using Big data. 5. Prenatal exposure to diethylstilbestrol and clear cell adenocarcinoma of vagina and cervix, as well as other health conditions in later life. 6. Epigenetics and non-coding RNAs, such as microRNAs in relationship to cancer prognosis and survival.
One or more keywords matched the following items that are connected to Huo, Dezheng
Item TypeName
Concept Genetic Association Studies
Concept Genome-Wide Association Study
Academic Article Clinical-cytogenetic associations in 306 patients with therapy-related myelodysplasia and myeloid leukemia: the University of Chicago series.
Academic Article Interpretation of genome-wide association study results.
Academic Article Lack of association between common single nucleotide polymorphisms in the TERT-CLPTM1L locus and breast cancer in women of African ancestry.
Academic Article Evaluation of 19 susceptibility loci of breast cancer in women of African ancestry.
Academic Article Recurrent BRCA1 and BRCA2 mutations in breast cancer patients of African ancestry.
Academic Article Ancestry-shift refinement mapping of the C6orf97-ESR1 breast cancer susceptibility locus.
Academic Article Lack of association of the TP53 Arg72Pro SNP and the MDM2 SNP309 with systemic lupus erythematosus in Caucasian, African American, and Asian children and adults.
Academic Article Association between colorectal cancer and urologic cancers.
Academic Article Association of colorectal cancer and prostate cancer and impact of radiation therapy.
Academic Article Lack of association between common UGT2B nonsynonymous single-nucleotide polymorphisms and breast cancer in populations of African ancestry.
Academic Article Fine mapping of breast cancer genome-wide association studies loci in women of African ancestry identifies novel susceptibility markers.
Academic Article Genome-wide association study in BRCA1 mutation carriers identifies novel loci associated with breast and ovarian cancer risk.
Academic Article A genome-wide association study of breast cancer in women of African ancestry.
Academic Article A meta-analysis identifies new loci associated with body mass index in individuals of African ancestry.
Academic Article Association of type and location of BRCA1 and BRCA2 mutations with risk of breast and ovarian cancer.
Academic Article Pilot study demonstrating potential association between breast cancer image-based risk phenotypes and genomic biomarkers.
Academic Article A comprehensive examination of breast cancer risk loci in African American women.
Academic Article Genetic variants in microRNA and microRNA biogenesis pathway genes and breast cancer risk among women of African ancestry.
Academic Article Genetic and Epigenetic Regulation of TOX3 Expression in Breast Cancer.
Academic Article Genome-wide association studies in women of African ancestry identified 3q26.21 as a novel susceptibility locus for oestrogen receptor negative breast cancer.
Academic Article Association of breast cancer risk and the mTOR pathway in women of African ancestry in 'The Root' Consortium.
Academic Article Genetic variants demonstrating flip-flop phenomenon and breast cancer risk prediction among women of African ancestry.
Academic Article Genetic variation in the vitamin D related pathway and breast cancer risk in women of African ancestry in the root consortium.
Academic Article Genetic variation in the Hippo pathway and breast cancer risk in women of African ancestry.
Academic Article A meta-analysis approach with filtering for identifying gene-level gene-environment interactions.
Academic Article Association of Pancreatic Cancer Susceptibility Variants with Risk of Breast Cancer in Women of European and African Ancestry.
Academic Article Germline Variation and Breast Cancer Incidence: A Gene-Based Association Study and Whole-Genome Prediction of Early-Onset Breast Cancer.
Academic Article Trans-ethnic predicted expression genome-wide association analysis identifies a gene for estrogen receptor-negative breast cancer.
Academic Article Identification of novel common breast cancer risk variants at the 6q25 locus among Latinas.
Academic Article The association between weight at birth and breast cancer risk revisited using Mendelian randomisation.
Academic Article Body mass index and the association between low-density lipoprotein cholesterol as predicted by HMGCR genetic variants and breast cancer risk.
Grant UChicago Interdisciplinary Cancer Health Disparities SPORE
Academic Article BRCA1 and BRCA2 pathogenic sequence variants in women of African origin or ancestry.
Academic Article Discovery and fine-mapping of height loci via high-density imputation of GWASs in individuals of African ancestry.
Academic Article Cross-ancestry GWAS meta-analysis identifies six breast cancer loci in African and European ancestry women.
Academic Article Associations between age of menarche and genetic variation in women of African descent: genome-wide association study and polygenic score analysis.
Academic Article Polygenic risk scores for prediction of breast cancer risk in women of African ancestry: a cross-ancestry approach.
Academic Article Aggregation tests identify new gene associations with breast cancer in populations with diverse ancestry.
Academic Article An enhancer variant associated with breast cancer susceptibility in Black women regulates TNFSF10 expression and antitumor immunity in triple-negative breast cancer.
Grant Replication Study of Breast Cancer Susceptibility Genes in Blacks
Grant Integrative Genetic Epidemiologic Study of Breast Cancer Subtypes
Grant Genetic Risk Prediction of Breast Cancer for African Americans
Grant Transcriptome-wide association studies and genetic risk prediction for breast cancer integrating RNA splicing and gene expression from multiple tissues
Grant Using Genomics to Reduce Breast Cancer Disparities in the African Diaspora
Academic Article Prediction of Breast and Prostate Cancer Risks in Male BRCA1 and BRCA2 Mutation Carriers Using Polygenic Risk Scores.
Academic Article A joint transcriptome-wide association study across multiple tissues identifies candidate breast cancer susceptibility genes.
Academic Article Association of ESR1 germline variants with TP53 somatic variants in breast tumors in a genome-wide study.
Academic Article Novel breast cancer susceptibility loci under linkage peaks identified in African ancestry consortia.
Academic Article Multi-tissue transcriptome-wide association studies identified 235 genes for intrinsic subtypes of breast cancer.
Academic Article Expression- and splicing-based multi-tissue transcriptome-wide association studies identified multiple genes for breast cancer by estrogen-receptor status.
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