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Ratain, Mark J.

One or more keywords matched the following items that are connected to Ratain, Mark J.

Item Type	Name
Concept	Camptothecin
Academic Article	Modulation of glucuronidation of SN-38, the active metabolite of irinotecan, by valproic acid and phenobarbital.
Academic Article	Treatment-related fatal sepsis from topotecan/cisplatin and topotecan/paclitaxel.
Academic Article	Limited-sampling models for irinotecan pharmacokinetics-pharmacodynamics: prediction of biliary index and intestinal toxicity.
Academic Article	Pharmacokinetic and pharmacodynamic evaluation of the topoisomerase inhibitor irinotecan in cancer patients.
Academic Article	A phase II study of 9-aminocamptothecin in advanced non-small-cell lung cancer.
Academic Article	Phase I clinical and pharmacokinetic study of oral 9-aminocamptothecin (NSC-603071).
Academic Article	Promising new agents in oncologic treatment.
Academic Article	Genetic predisposition to the metabolism of irinotecan (CPT-11). Role of uridine diphosphate glucuronosyltransferase isoform 1A1 in the glucuronidation of its active metabolite (SN-38) in human liver microsomes.
Academic Article	Phenotype-genotype correlation of in vitro SN-38 (active metabolite of irinotecan) and bilirubin glucuronidation in human liver tissue with UGT1A1 promoter polymorphism.
Academic Article	Pharmacokinetics and pharmacodynamics of 9-aminocamptothecin infused over 72 hours in phase II studies.
Academic Article	Clinical pharmacology of camptothecins.
Academic Article	Insights into the pharmacokinetics and pharmacodynamics of irinotecan.
Academic Article	Irinotecan dosing: does the CPT in CPT-11 stand for "Can't Predict Toxicity"?
Academic Article	UGT1A1*28 polymorphism as a determinant of irinotecan disposition and toxicity.
Academic Article	Pharmacogenetics: a tool for individualizing antineoplastic therapy.
Academic Article	Pharmacogenetics of anticancer agents: lessons from amonafide and irinotecan.
Academic Article	Population pharmacokinetic model for irinotecan and two of its metabolites, SN-38 and SN-38 glucuronide.
Academic Article	Biliary transport of irinotecan and metabolites in normal and P-glycoprotein-deficient mice.
Academic Article	Pharmacogenomics: road to anticancer therapeutics nirvana?
Academic Article	A phase I and pharmacokinetic study of irinotecan in patients with hepatic or renal dysfunction or with prior pelvic radiation: CALGB 9863.
Academic Article	Relationship of baseline serum bilirubin to efficacy and toxicity of single-agent irinotecan in patients with metastatic colorectal cancer.
Academic Article	"Irinogenetics" and UGT1A: from genotypes to haplotypes.
Academic Article	Genetic variants in the UDP-glucuronosyltransferase 1A1 gene predict the risk of severe neutropenia of irinotecan.
Academic Article	Haplotype structure of the UDP-glucuronosyltransferase 1A1 promoter in different ethnic groups.
Academic Article	Irinotecan treatment in cancer patients with UGT1A1 polymorphisms.
Academic Article	Modulation of irinotecan with cyclosporine: a phase II trial in advanced colorectal cancer.
Academic Article	Effects of ketoconazole on glucuronidation by UDP-glucuronosyltransferase enzymes.
Academic Article	From bedside to bench to bedside to clinical practice: an odyssey with irinotecan.
Academic Article	Irinogenetics: what is the right star?
Academic Article	Effects of green tea compounds on irinotecan metabolism.
Academic Article	The role of SN-38 exposure, UGT1A1*28 polymorphism, and baseline bilirubin level in predicting severe irinotecan toxicity.
Academic Article	The Werner's syndrome 4330T>C (Cys1367Arg) gene variant does not affect the in vitro cytotoxicity of topoisomerase inhibitors and platinum compounds.
Academic Article	Study of the genetic determinants of UGT1A1 inducibility by phenobarbital in cultured human hepatocytes.
Academic Article	Pharmacodynamic genes do not influence risk of neutropenia in cancer patients treated with moderately high-dose irinotecan.
Academic Article	The effect of thalidomide on the pharmacokinetics of irinotecan and metabolites in advanced solid tumor patients.
Academic Article	Haplotypes of variants in the UDP-glucuronosyltransferase1A9 and 1A1 genes.
Academic Article	The UGT1A1*28 polymorphism correlates with erlotinib's effect on SN-38 glucuronidation.
Academic Article	TPMT, UGT1A1 and DPYD: genotyping to ensure safer cancer therapy?
Academic Article	Phase I study of paclitaxel and topotecan in patients with advanced tumors: a cancer and leukemia group B study.
Academic Article	Pharmacogenetics and pharmacogenomics of anticancer agents.
Academic Article	Comprehensive pharmacogenetic analysis of irinotecan neutropenia and pharmacokinetics.
Academic Article	Individualizing dosing of irinotecan.
Academic Article	Pharmacokinetic modulation of irinotecan and metabolites by cyclosporin A.
Academic Article	A phase I trial of pharmacologic modulation of irinotecan with cyclosporine and phenobarbital.
Academic Article	Pharmacogenetics of irinotecan: clinical perspectives on the utility of genotyping.
Academic Article	UGT1A1*28 genotype affects the in-vitro glucuronidation of thyroxine in human livers.
Academic Article	Pharmacogenetic pathway analysis of irinotecan.
Academic Article	Pharmacogenetic testing for uridine diphosphate glucuronosyltransferase 1A1 polymorphisms: are we there yet?
Academic Article	Phase II study of 9-aminocamptothecin in previously treated lymphomas: results of Cancer and Leukemia Group B 9551.
Academic Article	Metabolic fate of irinotecan in humans: correlation of glucuronidation with diarrhea.
Academic Article	Dose-finding and pharmacokinetic study to optimize the dosing of irinotecan according to the UGT1A1 genotype of patients with cancer.
Academic Article	Clinical validity of new genetic biomarkers of irinotecan neutropenia: an independent replication study.
Academic Article	Genomic Analysis of Germline Variation Associated with Survival of Patients with Colorectal Cancer Treated with Chemotherapy Plus Biologics in CALGB/SWOG 80405 (Alliance).

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Camptothecin