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Ratain, Mark J.

One or more keywords matched the following items that are connected to Ratain, Mark J.

Item Type	Name
Concept	Glucuronosyltransferase
Academic Article	Modulation of glucuronidation of SN-38, the active metabolite of irinotecan, by valproic acid and phenobarbital.
Academic Article	Genetic predisposition to the metabolism of irinotecan (CPT-11). Role of uridine diphosphate glucuronosyltransferase isoform 1A1 in the glucuronidation of its active metabolite (SN-38) in human liver microsomes.
Academic Article	Phenotype-genotype correlation of in vitro SN-38 (active metabolite of irinotecan) and bilirubin glucuronidation in human liver tissue with UGT1A1 promoter polymorphism.
Academic Article	Pharmacogenetics in cancer etiology and chemotherapy.
Academic Article	Irinotecan dosing: does the CPT in CPT-11 stand for "Can't Predict Toxicity"?
Academic Article	UGT1A1*28 polymorphism as a determinant of irinotecan disposition and toxicity.
Academic Article	Pharmacogenetics: a tool for individualizing antineoplastic therapy.
Academic Article	Phase I clinical and pharmacogenetic study of weekly TAS-103 in patients with advanced cancer.
Academic Article	A pharmacogenetic study of uridine diphosphate-glucuronosyltransferase 2B7 in patients receiving morphine.
Academic Article	In vitro characterization of hepatic flavopiridol metabolism using human liver microsomes and recombinant UGT enzymes.
Academic Article	Epirubicin glucuronidation is catalyzed by human UDP-glucuronosyltransferase 2B7.
Academic Article	"Irinogenetics" and UGT1A: from genotypes to haplotypes.
Academic Article	Genetic variants in the UDP-glucuronosyltransferase 1A1 gene predict the risk of severe neutropenia of irinotecan.
Academic Article	Haplotype structure of the UDP-glucuronosyltransferase 1A1 promoter in different ethnic groups.
Academic Article	Irinotecan treatment in cancer patients with UGT1A1 polymorphisms.
Academic Article	UGT pharmacogenomics: implications for cancer risk and cancer therapeutics.
Academic Article	Effects of ketoconazole on glucuronidation by UDP-glucuronosyltransferase enzymes.
Academic Article	Hepatocyte nuclear factor-1 alpha is associated with UGT1A1, UGT1A9 and UGT2B7 mRNA expression in human liver.
Academic Article	Global gene expression as a function of germline genetic variation.
Academic Article	From bedside to bench to bedside to clinical practice: an odyssey with irinotecan.
Academic Article	Irinogenetics: what is the right star?
Academic Article	Effects of green tea compounds on irinotecan metabolism.
Academic Article	Searching for tissue-specific expression pattern-linked nucleotides of UGT1A isoforms.
Academic Article	Lack of association between common polymorphisms in UGT1A9 and gene expression and activity.
Academic Article	The role of SN-38 exposure, UGT1A1*28 polymorphism, and baseline bilirubin level in predicting severe irinotecan toxicity.
Academic Article	Linkage disequilibrium across the UGT1A locus should not be ignored in association studies of cancer susceptibility.
Academic Article	Single nucleotide polymorphism discovery and functional assessment of variation in the UDP-glucuronosyltransferase 2B7 gene.
Academic Article	Study of the genetic determinants of UGT1A1 inducibility by phenobarbital in cultured human hepatocytes.
Academic Article	Comparison of the drug-drug interactions potential of erlotinib and gefitinib via inhibition of UDP-glucuronosyltransferases.
Academic Article	A pharmacogenetic study of vorinostat glucuronidation.
Academic Article	In vitro and in vivo oxidative metabolism and glucuronidation of anastrozole.
Academic Article	Re: CYP2D6 genotype and tamoxifen response in postmenopausal women with endocrine-responsive breast cancer: the Breast International Group 1-98 trial.
Academic Article	Haplotypes of variants in the UDP-glucuronosyltransferase1A9 and 1A1 genes.
Academic Article	Uridine 5'-diphospho-glucuronosyltransferase genetic polymorphisms and response to cancer chemotherapy.
Academic Article	The UGT1A1*28 polymorphism correlates with erlotinib's effect on SN-38 glucuronidation.
Academic Article	TPMT, UGT1A1 and DPYD: genotyping to ensure safer cancer therapy?
Academic Article	Comprehensive pharmacogenetic analysis of irinotecan neutropenia and pharmacokinetics.
Academic Article	Pharmacogenetics of irinotecan: clinical perspectives on the utility of genotyping.
Academic Article	UGT1A1*28 genotype affects the in-vitro glucuronidation of thyroxine in human livers.
Academic Article	Pharmacogenetic pathway analysis of irinotecan.
Academic Article	Pharmacogenetic testing for uridine diphosphate glucuronosyltransferase 1A1 polymorphisms: are we there yet?
Academic Article	Inhibition of paracetamol glucuronidation by tyrosine kinase inhibitors.
Academic Article	Glucuronidation by UGT1A1 is the dominant pathway of the metabolic disposition of belinostat in liver cancer patients.
Academic Article	Preclinical discovery of candidate genes to guide pharmacogenetics during phase I development: the example of the novel anticancer agent ABT-751.
Academic Article	Dose-finding and pharmacokinetic study to optimize the dosing of irinotecan according to the UGT1A1 genotype of patients with cancer.
Academic Article	UGT1A and UGT2B genetic variation alters nicotine and nitrosamine glucuronidation in european and african american smokers.
Academic Article	Genetic factors affecting gene transcription and catalytic activity of UDP-glucuronosyltransferases in human liver.
Academic Article	Glucuronidation of OTS167 in Humans Is Catalyzed by UDP-Glucuronosyltransferases UGT1A1, UGT1A3, UGT1A8, and UGT1A10.
Academic Article	In vitro glucuronidation of aprepitant: a moderate inhibitor of UGT2B7.
Academic Article	Clinical Pharmacogenetics Implementation Consortium (CPIC) Guideline for UGT1A1 and Atazanavir Prescribing.

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Glucuronosyltransferase