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One or more keywords matched the following items that are connected to Ratain, Mark J.
Item TypeName
Concept Patient Care
Concept Patient Education as Topic
Concept Patient Advocacy
Concept Patient Acceptance of Health Care
Concept Patients
Concept Analgesia, Patient-Controlled
Concept Patient-Centered Care
Concept Patient Protection and Affordable Care Act
Concept Patient Participation
Concept Patient Satisfaction
Concept Patient Selection
Concept Patient Compliance
Concept Physician-Patient Relations
Concept Patient Safety
Academic Article Statistical and ethical issues in the design and conduct of phase I and II clinical trials of new anticancer agents.
Academic Article Phase I study of suramin administered by intermittent infusion without adaptive control to cancer patients: update of two expanded dose levels near the maximally tolerated dose.
Academic Article Dose-escalation trial of cladribine using five daily intravenous infusions in patients with advanced hematologic malignancies.
Academic Article Ethical issues in phase I oncology research: a comparison of investigators and institutional review board chairpersons.
Academic Article New phase I trial methodology.
Academic Article Learning from our patients: one participant's impact on clinical trial research and informed consent.
Academic Article Pharmacokinetic and pharmacodynamic evaluation of the topoisomerase inhibitor irinotecan in cancer patients.
Academic Article Study of cohort-specific consent and patient control in phase I cancer trials.
Academic Article Phase I study of concomitant chemoradiotherapy with paclitaxel, fluorouracil, and hydroxyurea with granulocyte colony-stimulating factor support for patients with poor-prognosis cancer of the head and neck.
Academic Article Evaluation of neuropathy in patients on suramin treatment.
Academic Article Thymidylate synthase expression and response to neoadjuvant chemotherapy in patients with advanced head and neck cancer.
Academic Article Phase I and pharmacokinetic trial of gemcitabine in patients with hepatic or renal dysfunction: Cancer and Leukemia Group B 9565.
Academic Article Phase I and pharmacokinetic trial of paclitaxel in patients with hepatic dysfunction: Cancer and Leukemia Group B 9264.
Academic Article Phase I Trial of ISIS 5132, an antisense oligonucleotide inhibitor of c-raf-1, administered by 24-hour weekly infusion to patients with advanced cancer.
Academic Article Chronic daily low dose of 4-methyl-5-(2-pyrazinyl)-1,2-dithiole-3-thione (Oltipraz) in patients with previously resected colon polyps and first degree female relatives of breast cancer patients.
Academic Article Phase I and pharmacologic study of continuous infusion topotecan in combination with cisplatin in patients with advanced cancer: a Cancer and LeukemiaGroup B study.
Academic Article Flavopiridol metabolism in cancer patients is associated with the occurrence of diarrhea.
Academic Article Pharmacology of 21-day oral etoposide given in combination with i.v. cisplatin in patients with extensive-stage small cell lung cancer: a cancer and leukemia group B study (CALGB 9062).
Academic Article Quantitative analysis of ethical issues in phase I trials: a survey interview of 144 advanced cancer patients.
Academic Article Phase I study of eniluracil, a dihydropyrimidine dehydrogenase inactivator, and oral 5-fluorouracil with radiation therapy in patients with recurrent or advanced head and neck cancer.
Academic Article A Phase I study of raltitrexed and paclitaxel given every 3 weeks to patients with solid tumors.
Academic Article Dear doctor: we really are not sure what dose of capecitabine you should prescribe for your patient.
Academic Article A phase I study of suramin with once- or twice-monthly dosing in patients with advanced cancer.
Academic Article Elimination pathways of [14C]losoxantrone in four cancer patients.
Academic Article Phase I clinical and pharmacogenetic study of weekly TAS-103 in patients with advanced cancer.
Academic Article Troxacitabine in patients with refractory leukemia.
Academic Article Determination of the optimal modulatory dose of O6-benzylguanine in patients with surgically resectable tumors.
Academic Article Randomized study of three different doses of suramin administered with a fixed dosing schedule in patients with advanced prostate cancer: results of intergroup 0159, cancer and leukemia group B 9480.
Academic Article Phase I study of pegylated liposomal doxorubicin, paclitaxel, and cisplatin in patients with advanced solid tumors.
Academic Article Dose-escalating study of capecitabine plus gemcitabine combination therapy in patients with advanced cancer.
Academic Article Phase I clinical and pharmacokinetic study of protein kinase C-alpha antisense oligonucleotide ISIS 3521 administered in combination with 5-fluorouracil and leucovorin in patients with advanced cancer.
Academic Article A pharmacogenetic study of uridine diphosphate-glucuronosyltransferase 2B7 in patients receiving morphine.
Academic Article Correspondence re: Raida, M. et al., prevalence of a common point mutation in the dihydropyrimidine dehydrogenase (DPD) gene within the 5'-splice donor site of intron 14 in patients with severe 5-fluorouracil (5-FU)-related toxicity compared with controls.
Academic Article Phase I study to evaluate multiple regimens of intravenous 5-fluorouracil administered in combination with weekly gemcitabine in patients with advanced solid tumors: a potential broadly active regimen for advanced solid tumor malignancies.
Academic Article A phase I and pharmacokinetic study of irinotecan in patients with hepatic or renal dysfunction or with prior pelvic radiation: CALGB 9863.
Academic Article Estimation of the glomerular filtration rate in cancer patients: a new formula for new drugs.
Academic Article Relationship of baseline serum bilirubin to efficacy and toxicity of single-agent irinotecan in patients with metastatic colorectal cancer.
Academic Article Phase I clinical trial of CEP-2563 dihydrochloride, a receptor tyrosine kinase inhibitor, in patients with refractory solid tumors.
Academic Article Treatment of chemotherapy-induced anemia with recombinant human erythropoietin in cancer patients.
Academic Article Pentostatin pharmacokinetics and dosing recommendations in patients with mild renal impairment.
Academic Article A phase I trial of pharmacokinetic modulation of carboxyamidotriazole (CAI) with ketoconazole in patients with advanced cancer.
Academic Article A phase I study of cantuzumab mertansine administered as a single intravenous infusion once weekly in patients with advanced solid tumors.
Academic Article Dose-ranging study of the safety and pharmacokinetics of atrasentan in patients with refractory malignancies.
Academic Article A phase I trial of gemcitabine plus cladribine in patients with advanced hematologic malignant diseases.
Academic Article Irinotecan treatment in cancer patients with UGT1A1 polymorphisms.
Academic Article Delivery of a liposomal c-raf-1 antisense oligonucleotide by weekly bolus dosing in patients with advanced solid tumors: a phase I study.
Academic Article Pharmacokinetics, pharmacodynamics and adherence to oral topotecan in myelodysplastic syndromes: a Cancer and Leukemia Group B study.
Academic Article A comparison of the pharmacokinetics and pharmacodynamics of docetaxel between African-American and Caucasian cancer patients: CALGB 9871.
Academic Article Prospective evaluation of the relationship of patient age and paclitaxel clinical pharmacology: Cancer and Leukemia Group B (CALGB 9762).
Academic Article Phase II placebo-controlled randomized discontinuation trial of sorafenib in patients with metastatic renal cell carcinoma.
Academic Article Phase I study of inhaled Doxorubicin for patients with metastatic tumors to the lungs.
Academic Article Inside information: Financial conflicts of interest for research subjects in early phase clinical trials.
Academic Article A phase I trial to determine the safety, tolerability, and maximum tolerated dose of deforolimus in patients with advanced malignancies.
Academic Article A phase I study of antisense oligonucleotide GTI-2040 given by continuous intravenous infusion in patients with advanced solid tumors.
Academic Article Phase I and pharmacokinetic study of sorafenib in patients with hepatic or renal dysfunction: CALGB 60301.
Academic Article Pharmacodynamic genes do not influence risk of neutropenia in cancer patients treated with moderately high-dose irinotecan.
Academic Article The design of phase II clinical trials testing cancer therapeutics: consensus recommendations from the clinical trial design task force of the national cancer institute investigational drug steering committee.
Academic Article A dosing/cross-development study of the multikinase inhibitor sorafenib in patients with pulmonary arterial hypertension.
Academic Article Complementary and alternative medicine among advanced cancer patients enrolled on phase I trials: a study of prognosis, quality of life, and preferences for decision making.
Academic Article Pharmacokinetic modulation of oral etoposide by ketoconazole in patients with advanced cancer.
Academic Article Dose reduction of etoposide in jaundiced patients.
Academic Article Phase I and pharmacokinetic study of erlotinib for solid tumors in patients with hepatic or renal dysfunction: CALGB 60101.
Academic Article Attitudes toward research participation and investigator conflicts of interest among advanced cancer patients participating in early phase clinical trials.
Academic Article A phase I study of continuous infusion cilengitide in patients with solid tumors.
Academic Article A phase I study of sirolimus and bevacizumab in patients with advanced malignancies.
Academic Article Phase I study of the ribonucleotide reductase inhibitor 3-aminopyridine-2-carboxaldehyde-thiosemicarbazone (3-AP) in combination with high dose cytarabine in patients with advanced myeloid leukemia.
Academic Article The effect of thalidomide on the pharmacokinetics of irinotecan and metabolites in advanced solid tumor patients.
Academic Article Alpha-2 interferon therapy of hairy-cell leukemia: a multicenter study of 64 patients.
Academic Article Activity of XL184 (Cabozantinib), an oral tyrosine kinase inhibitor, in patients with medullary thyroid cancer.
Academic Article Randomized study of the duration of treatment with interferon alfa-2B in patients with hairy cell leukemia.
Academic Article Interferon treatment for hairy cell leukemia. An update on a cohort of 69 patients treated from 1983 to 1986.
Academic Article Prognostic factors for survival in patients treated in phase I clinical trials.
Academic Article A randomized study of inpatient versus outpatient continuous infusion chemotherapy for patients with locally advanced head and neck cancer.
Academic Article A programmable and implantable pumping system for systemic chemotherapy: a performance analysis in 52 patients.
Academic Article A genome-wide association study of overall survival in pancreatic cancer patients treated with gemcitabine in CALGB 80303.
Academic Article Sequential evaluation of alpha-2b-interferon treatment in 128 patients with hairy cell leukemia.
Academic Article The 1200 patients project: creating a new medical model system for clinical implementation of pharmacogenomics.
Academic Article Encephalopathy is the dose-limiting toxicity of intravenous hepsulfam: results of a phase I trial in patients with advanced hematological malignancies.
Academic Article Randomized phase II trials: a long-term investment with promising returns.
Academic Article Germline pharmacogenomics in oncology: decoding the patient for targeting therapy.
Academic Article Pharmacogenomics and patient care: one size does not fit all.
Academic Article Phase I trial of a genetically engineered interleukin-2 fusion toxin (DAB486IL-2) as a 6 hour intravenous infusion in patients with hematologic malignancies.
Academic Article Phase I study of suramin given by intermittent infusion without adaptive control in patients with advanced cancer.
Academic Article Report of a multi-institutional study of 193 patients with hairy cell leukemia treated with interferon-alfa2b.
Academic Article A phase I study of intermittent infusion cladribine in patients with solid tumors.
Academic Article Phase I clinical and pharmacological study of thymidine (NSC 21548) and cis-diamminedichloroplatinum(II) in patients with advanced cancer.
Academic Article A phase I and pharmacokinetic study of the quinoxaline antitumour Agent R(+)XK469 in patients with advanced solid tumours.
Academic Article Phase I study of paclitaxel and topotecan in patients with advanced tumors: a cancer and leukemia group B study.
Academic Article Comprehensive pharmacogenetic analysis of irinotecan neutropenia and pharmacokinetics.
Academic Article Interferon treatment for hairy cell leukemia: an update on a cohort of 69 patients treated from 1983-1986.
Academic Article Phase I clinical and pharmacological study of iododeoxyuridine and bleomycin in patients with advanced cancer.
Academic Article Perceptions of cancer patients and their physicians involved in phase I trials.
Academic Article Physician-determined patient risk of toxic effects: impact on enrollment and decision making in phase I cancer trials.
Academic Article Phase I clinical and pharmacologic study of eniluracil plus fluorouracil in patients with advanced cancer.
Academic Article Phase II and pharmacodynamic studies of pyrazine diazohydroxide (NSC 361456) in patients with advanced renal and colorectal cancer.
Academic Article Phase I clinical and pharmacological study of O6-benzylguanine followed by carmustine in patients with advanced cancer.
Academic Article Phase I study of the combination of losoxantrone and cyclophosphamide in patients with refractory solid tumours.
Academic Article A phase I study of cisplatin, 5-fluorouracil and leucovorin with escalating doses of hydroxyurea in chemotherapy naive patients.
Academic Article Phase 1 dose escalation study of docetaxel with filgrastim support in patients with advanced solid tumors.
Academic Article Phase I and pharmacokinetic study of 24-hour infusion 5-fluorouracil and leucovorin in patients with organ dysfunction.
Academic Article Quality of life impact of three different doses of suramin in patients with metastatic hormone-refractory prostate carcinoma: results of Intergroup O159/Cancer and Leukemia Group B 9480.
Academic Article Dose-ranging pharmacodynamic study of tipifarnib (R115777) in patients with relapsed and refractory hematologic malignancies.
Academic Article A phase I and pharmacokinetic study of XK469R (NSC 698215), a quinoxaline phenoxypropionic acid derivative, in patients with refractory acute leukemia.
Academic Article Efficacy and safety of sorafenib in a subset of patients with advanced soft tissue sarcoma from a Phase II randomized discontinuation trial.
Academic Article Plasma pharmacokinetics of high-dose oral melphalan in patients treated with trialkylator chemotherapy and autologous bone marrow reinfusion.
Academic Article Two drug interaction studies of sirolimus in combination with sorafenib or sunitinib in patients with advanced malignancies.
Academic Article Phase-I trial of Thiotepa, granulocyte-macrophage colony-stimulating factor and prednisone or pentoxifylline in patients with refractory solid tumors.
Academic Article Phase I studies of sirolimus alone or in combination with pharmacokinetic modulators in advanced cancer patients.
Academic Article Playing Russian roulette with tyrosine kinase inhibitors.
Academic Article Evaluation of food effect on pharmacokinetics of vismodegib in advanced solid tumor patients.
Academic Article Glucuronidation by UGT1A1 is the dominant pathway of the metabolic disposition of belinostat in liver cancer patients.
Academic Article Nonlinear population pharmacokinetics of sirolimus in patients with advanced cancer.
Academic Article Sorafenib dose escalation is not uniformly associated with blood pressure elevations in normotensive patients with advanced malignancies.
Academic Article Estimation of Progression-Free Survival for All Treated Patients in the Randomized Discontinuation Trial Design.
Academic Article Dose-finding and pharmacokinetic study to optimize the dosing of irinotecan according to the UGT1A1 genotype of patients with cancer.
Academic Article Phase I dose-escalation study of onartuzumab as a single agent and in combination with bevacizumab in patients with advanced solid malignancies.
Academic Article Design of phase I combination trials: recommendations of the Clinical Trial Design Task Force of the NCI Investigational Drug Steering Committee.
Academic Article Bevacizumab and the risk of arterial and venous thromboembolism in patients with metastatic, castration-resistant prostate cancer treated on Cancer and Leukemia Group B (CALGB) 90401 (Alliance).
Academic Article Effect of age on the pharmacokinetics of busulfan in patients undergoing hematopoietic cell transplantation; an alliance study (CALGB 10503, 19808, and 100103).
Academic Article First-in-human phase I study of Lurbinectedin (PM01183) in patients with advanced solid tumors.
Academic Article Vatalanib population pharmacokinetics in patients with myelodysplastic syndrome: CALGB 10105 (Alliance).
Academic Article Adoption of a clinical pharmacogenomics implementation program during outpatient care--initial results of the University of Chicago "1,200 Patients Project".
Academic Article The development of a financial toxicity patient-reported outcome in cancer: The COST measure.
Academic Article Forecasting unanticipated consequences of "The Sunshine Act": mostly cloudy.
Academic Article User beware: we need more science and less art when measuring financial toxicity in oncology.
Academic Article A pharmacogenetic study of aldehyde oxidase I in patients treated with XK469.
Academic Article Evidence for Clinical Implementation of Pharmacogenomics in Cardiac Drugs.
Academic Article Participation in Cancer Pharmacogenomic Studies: A Study of 8456 Patients Registered to Clinical Trials in the Cancer and Leukemia Group B (Alliance).
Academic Article First-in-human, phase I study of elisidepsin (PM02734) administered as a 30-min or as a 3-hour intravenous infusion every three weeks in patients with advanced solid tumors.
Academic Article Harmonization of Renal Function Assessment Is Needed During Early Clinical Development of Oncology Drugs.
Academic Article Interferon Alfa-2b Antibodies and Clinical Resistance in a Patient with Hairy Cell Leukemia.
Academic Article Survival Experience of 195 Patients with Hairy Cell Leukemia Treated in a Multi-Institutional Study with Interferon-Alfa 2B.
Academic Article Low Dose Interferon Alfa-2B for the Induction of Remission of Hairy Cell Leukemia: A Multi-institutional Study of 49 Patients.
Academic Article Measuring financial toxicity as a clinically relevant patient-reported outcome: The validation of the COmprehensive Score for financial Toxicity (COST).
Academic Article Drug-Drug Interactions With Oral Antineoplastic Agents.
Academic Article Patient Perceptions of Care as Influenced by a Large Institutional Pharmacogenomic Implementation Program.
Academic Article A phase I study of XL184, a RET, VEGFR2, and MET kinase inhibitor, in patients (pts) with advanced malignancies, including pts with medullary thyroid cancer (MTC).
Academic Article A study of informed consent (IC), age, and cognitive performance (CP) among advanced cancer patients (acp) in phase I trials.
Academic Article Final findings from a phase II, placebo-controlled, randomized discontinuation trial (RDT) of sorafenib (BAY 43-9006) in patients with advanced renal cell carcinoma (RCC).
Academic Article Phase I study of belinostat (PXD101) plus azacitidine (AZC) in patients with advanced myeloid neoplasms.
Academic Article A drug interaction study of sorafenib (S) and rapamycin (R) in patients with advanced malignancies.
Academic Article Assessment of patient perceptions of genomic testing to inform pharmacogenomic implementation.
Academic Article Kinetic-Pharmacodynamic Model of Chemotherapy-Induced Peripheral Neuropathy in Patients with Metastatic Breast Cancer Treated with Paclitaxel, Nab-Paclitaxel, or Ixabepilone: CALGB 40502 (Alliance).
Academic Article Analyzing the clinical actionability of germline pharmacogenomic findings in oncology.
Academic Article Genetic variation determines VEGF-A plasma levels in cancer patients.
Academic Article Do Patients With Advanced Cancer Have the Ability to Make Informed Decisions for Participation in Phase I Clinical Trials?
Academic Article The vitamin D receptor gene as a determinant of survival in pancreatic cancer patients: Genomic analysis and experimental validation.
Academic Article Safety and Clinical Activity of Pembrolizumab and Multisite Stereotactic Body Radiotherapy in Patients With Advanced Solid Tumors.
Academic Article A pharmacodynamic study of sirolimus and metformin in patients with advanced solid tumors.
Academic Article Patient-provider communications about pharmacogenomic results increase patient recall of medication changes.
Academic Article An initial genetic analysis of gemcitabine-induced high-grade neutropenia in pancreatic cancer patients in CALGB 80303 (Alliance).
Academic Article Assessment of Patient Knowledge and Perceptions of Pharmacogenomics Before and After Using a Mock Results Patient Web Portal.
Academic Article Pharmacogenomic genotypes define genetic ancestry in patients and enable population-specific genomic implementation.
Academic Article Phase II randomised discontinuation trial of brivanib in patients with advanced solid tumours.
Academic Article Personalized Management of Chemotherapy-Induced Peripheral Neuropathy Based on a Patient Reported Outcome: CALGB 40502 (Alliance).
Academic Article Optimal Sampling Strategies for Irinotecan (CPT-11) and its Active Metabolite (SN-38) in Cancer Patients.
Academic Article Safety, Clinical Activity, and Biological Correlates of Response in Patients with Metastatic Melanoma: Results from a Phase I Trial of Atezolizumab-Letter.
Academic Article Weight-Based Dosing of Pembrolizumab Every 6 Weeks in the Time of COVID-19.
Academic Article Genomic Analysis of Germline Variation Associated with Survival of Patients with Colorectal Cancer Treated with Chemotherapy Plus Biologics in CALGB/SWOG 80405 (Alliance).
Academic Article Patient insights on features of an effective pharmacogenomics patient portal.
Academic Article Pharmacogenetic study in gastric cancer patients treated with adjuvant fluorouracil/leucovorin or epirubicin/cisplatin/fluorouracil before and after chemoradiation on CALGB 80101 (Alliance).
Academic Article Negative innovation: when patents are bad for patients.
Academic Article Impact of CYP2D6 Pharmacogenomic Status on Pain Control Among Opioid-Treated Oncology Patients.
Academic Article Creation of a pharmacogenomics patient portal complementary to an existing institutional provider-facing clinical decision support system.
Academic Article Genome-wide association studies of survival in 1520 cancer patients treated with bevacizumab-containing regimens.
Academic Article Bevacizumab-induced hypertension and proteinuria: a genome-wide study of more than 1000 patients.
Academic Article Underrepresented patient views and perceptions of personalized medication treatment through pharmacogenomics.
Academic Article Correction: Bevacizumab-induced hypertension and proteinuria: a genome-wide study of more than 1000 patients.
Academic Article Applicability of Pharmacogenomically Guided Medication Treatment during Hospitalization of At-Risk Minority Patients.
Academic Article Clinically actionable genotypes for anticancer prescribing among >1500 patients with pharmacogenomic testing.
Academic Article Alternative trastuzumab dosing strategies in HER2-positive early breast cancer are associated with patient out-of-pocket savings.
Academic Article Eftozanermin alfa (ABBV-621) monotherapy in patients with previously treated solid tumors: findings of a phase 1, first-in-human study.
Academic Article Drug Interactions With a Short Course of Nirmatrelvir and Ritonavir: Prescribers and Patients Beware.
Concept Patient Reported Outcome Measures
Concept Patient Portals
Concept Patient Outcome Assessment
Concept Patient Harm
Academic Article Patient-centered, self-funding dose optimization trials as a route to reduce toxicity, lower cost, and improve access to cancer therapy.
Academic Article Common variation in a long non-coding RNA gene modulates variation of circulating TGF-ß2 levels in metastatic colorectal cancer patients (Alliance).
Academic Article Gene signatures derived from transcriptomic-causal networks stratified colorectal cancer patients for effective targeted therapy.
Academic Article Pharmacogenetic and clinical risk factors for bevacizumab-related gastrointestinal hemorrhage in prostate cancer patients treated on CALGB 90401 (Alliance).
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