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One or more keywords matched the following properties of Bissonnette, Bruce
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overview Brief Summary of Clinical activities: General gastroenterology. Diagnosis, management, and where appropriate, triage of patients with gastrointestinal disorders, including abdominal pain, GI bleeding, iron deficiency anemia, diarrhea, constipation, malabsorption, weight loss, GERD (esophageal reflux), swallowing difficulties, esophageal strictures, peptic ulcer disease, Barrett’s esophagus, irritable bowel syndrome (IBS), inflammatory bowel disease (IBD), colon polyps and colon cancer, diverticulitis, gastritis, H pylori infections, angioectasias (AVMs), radiation proctitis, pancreatitis and liver abnormalities. Brief Summary of Research activities: 1. Colon cancer pathogenesis and chemoprevention – Our laboratory is focused on the role of diet and signaling pathways that promote or inhibit colon cancer development. These include tumor-promoting Western diets, and inhibitory fish oil diets, growth factor signals and cytokine signals, focusing on ADAM17-EGFR and CXCL12-CXCR4. For these studies, we use animal models, primary human tissue and colonic organoids, and in vitro cell culture models. We are currently carrying out a broad screen of natural products for compounds that inhibit CXCL12-CXCR4 interaction as potential chemopreventive agents for colon cancer. 2. Development of a liquid biopsy (blood test) for colon cancer screening. In collaboration with Dr. Chuan He at the University of Chicago and Dr. Wei Zhang at Northwestern University, we are developing biomarker assays in the blood using 5-hydroxymethylcytosine to diagnose patients with advanced adenomas and early CRC. Similar assays will be used to prognosticate the likelihood of tumor recurrence and assess responses to anti-tumor therapies. 3. Elucidation of the role of Ythdf1 in colon cancer development. Ythdf1 binds N6-methyadenosine (m6A) in mRNA to increase mRNA translation We showed that deletion of Ythdf1 in dendritic cells activated the antigen-specific CD8+ T cell anti-tumor response allowing recognition and killing of colon cancer cells. We are currently studying conditional (LoxP) compound mutant mice with LoxP Ythdf1 and LoxP Apc genes to uncover the role of this m6A mRNA reader in early colonic carcinogenesis. 4. Dissection of the role of the pro-renin receptor (Atp6ap2) in colon cancer. In prior studies we showed that inhibition of the renin-angiotensin system (RAS) is essential for the chemopreventive efficacy of vitamin D to suppress colon tumor development. Vitamin D suppresses renin transcription to reduce RAS signals. AT1 receptor blockade by losartan also suppresses tumor development. The (pro)renin receptor binds renin and catalyzes renin protease activity and induces Wnt signaling. In collaboration with Dr. Yan Chun Li, we are investigating colonic tumorigenesis in mice with conditional deletion of (pro)renin receptor. This deletion (and wild type controls) will be combined with mice expressing a transgene driving renin over-expression.
One or more keywords matched the following items that are connected to Bissonnette, Bruce
Item TypeName
Concept Cholecalciferol
Concept Vitamin D Deficiency
Concept Vitamin D
Academic Article Ursodeoxycholic acid and F(6)-D(3) inhibit aberrant crypt proliferation in the rat azoxymethane model of colon cancer: roles of cyclin D1 and E-cadherin.
Academic Article Vitamin D receptor is not required for the rapid actions of 1,25-dihydroxyvitamin D3 to increase intracellular calcium and activate protein kinase C in mouse osteoblasts.
Academic Article Novel role of the vitamin D receptor in maintaining the integrity of the intestinal mucosal barrier.
Academic Article Inactivation of the vitamin D receptor in APC(min/+) mice reveals a critical role for the vitamin D receptor in intestinal tumor growth.
Academic Article 1,25-Dihydroxyvitamin D3 stimulates the phosphorylation of two acidic membrane proteins of 42,000 and 48,000 daltons in rat colonocytes: an effect modulated by vitamin D status.
Academic Article The role of protein kinase-C alpha in the activation of particulate guanylate cyclase by 1 alpha,25-dihydroxyvitamin D3 in CaCo-2 cells.
Academic Article 1,25(OH)2 vitamin D3 activates PKC-alpha in Caco-2 cells: a mechanism to limit secosteroid-induced rise in [Ca2+]i.
Academic Article A vitamin D analogue inhibits colonic carcinogenesis in the AOM/DSS model.
Academic Article Vitamin D status modulates rat colonic M3 muscarinic receptor characteristics and coupling to guanylate cyclase.
Academic Article 1,25-Dihydroxyvitamin D3 and 12-O-tetradecanoyl phorbol 13-acetate cause differential activation of Ca(2+)-dependent and Ca(2+)-independent isoforms of protein kinase C in rat colonocytes.
Academic Article The renin-angiotensin system mediates EGF receptor-vitamin d receptor cross-talk in colitis-associated colon cancer.
Academic Article Rapid effects of 1,25(OH)2 vitamin D3 on signal transduction systems in colonic cells.
Academic Article Intestinal epithelial vitamin D receptor signaling inhibits experimental colitis.
Academic Article Lithocholic acid down-regulation of NF-kappaB activity through vitamin D receptor in colonic cancer cells.
Academic Article A vitamin D3 analog induces a G1-phase arrest in CaCo-2 cells by inhibiting cdk2 and cdk6: roles of cyclin E, p21Waf1, and p27Kip1.
Academic Article Protein kinase C isoforms in the chemopreventive effects of a novel vitamin D3 analogue in rat colonic tumorigenesis.
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  • Cholecalciferol