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One or more keywords matched the following properties of Dignam, James J.
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overview Dr. Dignam's primary research involves the design, conduct, and analysis of cancer clinical trials, including early development (phase I), pilot efficacy and safety (phase II), and definitive evaluation (phase III) trials. He is the Executive Director of the Statistics and Data Management Center for NRG Oncology, a National Cancer Institute sponsored multi-center clinical trials group with over 500 recruitment sites in North America and beyond and over 100 active clinical trials. Dr. Dignam's methodology interests include trial monitoring and early stopping rules, competing risks, hazard function estimation, and prognostic modeling. He also has engaged in and led investigations into sociodemographic factors such as race/ethnicity and BMI/obesity on cancer prognosis and treatment response. Courses taught include introductory biostatistics, clinical trials, survival analysis, and regression modeling methods.
Person ID 1491
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Concept Activities of Daily Living
Concept Aged, 80 and over
Concept Aged
Concept Body Composition
Concept Aneuploidy
Concept Anticoagulants
Concept Antimetabolites, Antineoplastic
Concept Antineoplastic Combined Chemotherapy Protocols
Concept Antioxidants
Concept Analysis of Variance
Concept B-Lymphocytes
Concept Bayes Theorem
Concept Bangladesh
Concept Azacitidine
Concept China
Concept Attitude of Health Personnel
Concept Body Weight
Concept Carcinoma, Basal Cell
Concept Carcinoma, Non-Small-Cell Lung
Concept Cell Division
Concept Ethics, Medical
Concept Flutamide
Concept Colonic Neoplasms
Concept Combined Modality Therapy
Concept Chicago
Concept Leucovorin
Concept Cooperative Behavior
Concept Dacarbazine
Concept Diffusion of Innovation
Concept DNA Repair
Concept Cause of Death
Concept Kallikreins
Concept Chromosomes, Human, Pair 17
Concept Fallopian Tubes
Concept Colorectal Neoplasms, Hereditary Nonpolyposis
Concept Cost-Benefit Analysis
Concept Cross-Sectional Studies
Concept Indoles
Concept Killer Cells, Natural
Concept Obesity
Concept Pharmacogenetics
Concept Immunohistochemistry
Concept Necrosis
Concept Ovariectomy
Concept Methotrexate
Concept Mice, Inbred C57BL
Concept Mice, Nude
Concept Middle Aged
Concept Nigeria
Concept Glutamates
Concept Rectal Neoplasms
Concept Guanine
Concept Cohort Studies
Concept Selenomethionine
Concept Health Knowledge, Attitudes, Practice
Concept Humans
Concept Body Mass Index
Concept Bone Marrow Transplantation
Concept United States
Concept Biomarkers, Tumor
Concept Tumor Necrosis Factor-alpha
Concept Tamoxifen
Concept Drug Design
Concept Biomarkers
Concept Genes, BRCA2
Concept DNA Modification Methylases
Concept Bias
Concept Proto-Oncogene Proteins c-myc
Concept Case-Control Studies
Concept Prostate-Specific Antigen
Concept Postmenopause
Concept North America
Concept Carcinoma, Lobular
Concept Mice, Knockout
Concept Interleukin-12
Concept Carcinoma, Ductal, Breast
Concept beta Catenin
Concept Antineoplastic Agents, Alkylating
Concept Angiogenesis Inhibitors
Concept BRCA1 Protein
Concept Disclosure
Concept CpG Islands
Concept Antineoplastic Agents, Hormonal
Concept Clinical Trials Data Monitoring Committees
Concept Electronic Mail
Concept Radiotherapy, Intensity-Modulated
Concept Cyclin-Dependent Kinase Inhibitor p16
Concept Patient Participation
Concept Quality-Adjusted Life Years
Concept Sentinel Lymph Node Biopsy
Concept Genes, BRCA1
Concept Radiotherapy, Conformal
Concept Interleukin-18
Concept Information Dissemination
Concept Promoter Regions, Genetic
Concept Mice
Concept Quinazolines
Concept Pyrroles
Concept National Cancer Institute (U.S.)
Concept Senegal
Concept Technology, Radiologic
Concept Biomedical Research
Concept Chemoradiotherapy
Concept Antibodies, Monoclonal, Humanized
Concept Vincristine
Concept Colorectal Neoplasms
Concept Interferon Regulatory Factor-1
Concept Selection Bias
Concept Multivariate Analysis
Concept Chemotherapy, Adjuvant
Concept Cell Hypoxia
Concept Receptor, ErbB-2
Concept DNA Methylation
Concept Coronavirus
Concept Neoadjuvant Therapy
Concept Cytostatic Agents
Concept Stroke
Concept Genes, erbB-2
Concept Gadolinium DTPA
Concept Arsenic Poisoning
Concept STAT1 Transcription Factor
Concept DNA Mismatch Repair
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Concept Health Literacy
Concept Anilides
Concept Body Surface Area
Concept Brain Neoplasms
Concept Canada
Concept Carcinoma, Intraductal, Noninfiltrating
Concept Data Interpretation, Statistical
Concept Doxorubicin
Concept Follow-Up Studies
Concept Levamisole
Concept Longitudinal Studies
Concept Lymphocytes
Concept Patient Compliance
Concept Prospective Studies
Concept Retrospective Studies
Concept T-Lymphocytes
Concept Signal Transduction
Concept Estrogen Replacement Therapy
Concept Tumor Suppressor Protein p53
Concept Anticarcinogenic Agents
Concept Radiotherapy, Adjuvant
Concept Genomics
Concept alpha-Tocopherol
Concept Risk Reduction Behavior
Concept Estrogen Receptor alpha
Concept Young Adult
Academic Article Sequential methotrexate and fluorouracil for the treatment of node-negative breast cancer patients with estrogen receptor-negative tumors: eight-year results from National Surgical Adjuvant Breast and Bowel Project (NSABP) B-13 and first report of findings from NSABP B-19 comparing methotrexate and fluorouracil with conventional cyclophosphamide, methotrexate, and fluorouracil.
Academic Article Tamoxifen and chemotherapy for lymph node-negative, estrogen receptor-positive breast cancer.
Academic Article Prognosis among African-American women and white women with lymph node negative breast carcinoma: findings from two randomized clinical trials of the National Surgical Adjuvant Breast and Bowel Project (NSABP).
Academic Article Five versus more than five years of tamoxifen therapy for breast cancer patients with negative lymph nodes and estrogen receptor-positive tumors.
Academic Article Coronary heart disease mortality and adjuvant tamoxifen therapy.
Academic Article Breast cancer trials on trial: a case of conflicting ethical interests.
Academic Article Methods for bounding the marginal survival distribution.
Academic Article Early stopping of a clinical trial when there is evidence of no treatment benefit: protocol B-14 of the National Surgical Adjuvant Breast and Bowel Project.
Academic Article Tamoxifen in treatment of intraductal breast cancer: National Surgical Adjuvant Breast and Bowel Project B-24 randomised controlled trial.
Academic Article Pathologic findings from the National Surgical Adjuvant Breast Project (NSABP) eight-year update of Protocol B-17: intraductal carcinoma.
Academic Article Prognosis and treatment of patients with breast tumors of one centimeter or less and negative axillary lymph nodes.
Academic Article Occurrence of stroke with tamoxifen in NSABP B-24.
Academic Article Prevention of invasive breast cancer in women with ductal carcinoma in situ: an update of the National Surgical Adjuvant Breast and Bowel Project experience.
Academic Article Outcomes among African-Americans and Caucasians in colon cancer adjuvant therapy trials: findings from the National Surgical Adjuvant Breast and Bowel Project.
Academic Article Findings from recent National Surgical Adjuvant Breast and Bowel Project adjuvant studies in stage I breast cancer.
Academic Article Differences in breast cancer prognosis among African-American and Caucasian women.
Academic Article Efficacy of systemic adjuvant therapy for breast cancer in African-American and Caucasian women.
Academic Article Five versus more than five years of tamoxifen for lymph node-negative breast cancer: updated findings from the National Surgical Adjuvant Breast and Bowel Project B-14 randomized trial.
Academic Article MYC is amplified in BRCA1-associated breast cancers.
Academic Article The role of cancer cooperative groups within the spectrum of cancer care.
Academic Article Benefits and costs of interventions to improve breast cancer outcomes in African American women.
Academic Article Is patient travel distance associated with survival on phase II clinical trials in oncology?
Academic Article Semiquantitative analysis of dynamic contrast enhanced MRI in cancer patients: Variability and changes in tumor tissue over time.
Academic Article Statistical considerations in assessing molecular markers for cancer prognosis and treatment efficacy.
Academic Article Mammographic density and breast cancer after ductal carcinoma in situ.
Academic Article Toward optimal screening strategies for older women. Costs, benefits, and harms of breast cancer screening by age, biology, and health status.
Academic Article Obesity, tamoxifen use, and outcomes in women with estrogen receptor-positive early-stage breast cancer.
Academic Article Colorectal cancer and race: understanding the differences in outcomes between African Americans and whites.
Academic Article How often do BRCA mutation carriers tell their young children of the family's risk for cancer? A study of parental disclosure of BRCA mutations to minors and young adults.
Academic Article BRCA1 promoter methylation in sporadic breast cancer is associated with reduced BRCA1 copy number and chromosome 17 aneusomy.
Academic Article Effects of obesity and race on prognosis in lymph node-negative, estrogen receptor-negative breast cancer.
Academic Article Body mass index and outcomes in patients who receive adjuvant chemotherapy for colon cancer.
Academic Article Long-term suppression of tumor growth by TNF requires a Stat1- and IFN regulatory factor 1-dependent IFN-gamma pathway but not IL-12 or IL-18.
Academic Article The ongoing search for the sources of the breast cancer survival disparity.
Academic Article Comments on: Yin W, Di G, Zhou L, Lu J, Liu G, Wu J, Shen K, Han Q, Shen Z, Shao Z. Time-varying pattern of recurrence risk for Chinese breast cancer patients.
Academic Article Treatment of lymph-node-negative, oestrogen-receptor-positive breast cancer: long-term findings from National Surgical Adjuvant Breast and Bowel Project randomised clinical trials.
Academic Article Early viewing of noninferiority trials in progress.
Academic Article Family history of pancreatic cancer in a high-risk cancer clinic: implications for risk assessment.
Academic Article Hazard of recurrence and adjuvant treatment effects over time in lymph node-negative breast cancer.
Academic Article Re: Racial disparities in cancer survival among randomized clinical trials of the Southwest Oncology Group.
Academic Article A missing data approach to semi-competing risks problems.
Academic Article Epidermal growth factor receptor inhibitor gefitinib added to chemoradiotherapy in locally advanced head and neck cancer.
Academic Article A pilot study of the vulnerable elders survey-13 compared with the comprehensive geriatric assessment for identifying disability in older patients with prostate cancer who receive androgen ablation.
Academic Article Long-term outcomes of invasive ipsilateral breast tumor recurrences after lumpectomy in NSABP B-17 and B-24 randomized clinical trials for DCIS.
Academic Article Estrogen receptor alpha, BRCA1, and FANCF promoter methylation occur in distinct subsets of sporadic breast cancers.
Academic Article Uptake and timing of bilateral prophylactic salpingo-oophorectomy among BRCA1 and BRCA2 mutation carriers.
Academic Article Population differences in breast cancer: survey in indigenous African women reveals over-representation of triple-negative breast cancer.
Academic Article p53 as a marker of prognosis in African-American women with breast cancer.
Academic Article Conditional survival and the choice of conditioning set for patients with colon cancer: an analysis of NSABP trials C-03 through C-07.
Academic Article Outcomes among black patients with stage II and III colon cancer receiving chemotherapy: an analysis of ACCENT adjuvant trials.
Academic Article Predictors of competing mortality in advanced head and neck cancer.
Academic Article Colorectal cancer model of health disparities: understanding mortality differences in minority populations.
Academic Article The use and interpretation of competing risks regression models.
Academic Article Appropriate chemotherapy dosing for obese adult patients with cancer: American Society of Clinical Oncology clinical practice guideline.
Academic Article Optimization of response classification criteria for patients with malignant pleural mesothelioma.
Academic Article Predictors of locoregional recurrence after neoadjuvant chemotherapy: results from combined analysis of National Surgical Adjuvant Breast and Bowel Project B-18 and B-27.
Academic Article Prognosis after ipsilateral breast tumor recurrence and locoregional recurrences in patients treated by breast-conserving therapy in five National Surgical Adjuvant Breast and Bowel Project protocols of node-negative breast cancer.
Academic Article Estimating breast cancer-specific and other-cause mortality in clinical trial and population-based cancer registry cohorts.
Academic Article Lumpectomy and radiation therapy for the treatment of intraductal breast cancer: findings from National Surgical Adjuvant Breast and Bowel Project B-17.
Academic Article Tamoxifen, radiation therapy, or both for prevention of ipsilateral breast tumor recurrence after lumpectomy in women with invasive breast cancers of one centimeter or less.
Academic Article Prognosis after rectal cancer in blacks and whites participating in adjuvant therapy randomized trials.
Academic Article Semiparametric models for cumulative incidence functions.
Academic Article Obesity and breast cancer prognosis: an expanding body of evidence.
Academic Article Choice and interpretation of statistical tests used when competing risks are present.
Academic Article Population-based survival-cure analysis of ER-negative breast cancer.
Academic Article Glioma-associated oncogene family zinc finger 1 expression and metastasis in patients with head and neck squamous cell carcinoma treated with radiation therapy (RTOG 9003).
Academic Article Race and the prognostic influence of p53 in women with breast cancer.
Academic Article Patterns of missing mini mental status exam (MMSE) in radiation therapy oncology group (RTOG) brain cancer trials.
Academic Article NCI-RTOG translational program strategic guidelines for the early-stage development of radiosensitizers.
Academic Article Disease volumes as a marker for patient response in malignant pleural mesothelioma.
Academic Article A nomogram for individualized estimation of survival among patients with brain metastasis.
Academic Article Bayesian Hierarchical Multiresolution Hazard Model for the Study of Time-Dependent Failure Patterns in Early Stage Breast Cancer.
Academic Article Hormone replacement therapy and breast cancer: heterogeneous risks by race, weight, and breast density.
Academic Article Individualized dynamic prediction of prostate cancer recurrence with and without the initiation of a second treatment: Development and validation.
Academic Article A tissue biomarker-based model that identifies patients with a high risk of distant metastasis and differential survival by length of androgen deprivation therapy in RTOG protocol 92-02.
Academic Article Building firm foundations for therapy development.
Academic Article Reply to M.C. Chamberlain.
Academic Article Prevention of colorectal cancer and dietary management.
Academic Article Variation over time and interdependence between disease progression and death among patients with glioblastoma on RTOG 0525.
Academic Article Randomized Phase III Noninferiority Study Comparing Two Radiotherapy Fractionation Schedules in Patients With Low-Risk Prostate Cancer.
Academic Article Comparison of futility monitoring guidelines using completed phase III oncology trials.
Academic Article A Multiresolution Hazard Model for Multicenter Survival Studies: Application to Tamoxifen Treatment in Early Stage Breast Cancer.
Academic Article An Evaluation of Psychosocial and Religious Belief Differences in a Diverse Racial and Socioeconomic Urban Cancer Population.
Academic Article Impact of ethnic neutropenia disparity analysis in NSABP breast trials of postoperative doxorubicin (A)/cyclophosphamide (C).
Academic Article Effect of body mass index on outcomes in patients with Dukes B and C colon cancer: An analysis of NSABP randomized trials.
Academic Article Universal screening for Lynch syndrome in a large consecutive cohort of Chinese colorectal cancer patients: High prevalence and unique molecular features.
Academic Article Detecting a Survival Benefit to Dose Escalation-Reply.
Academic Article Investigating the Effect of Reirradiation or Systemic Therapy in Patients With Glioblastoma After Tumor Progression: A Secondary Analysis of NRG Oncology/Radiation Therapy Oncology Group Trial 0525.
Academic Article Radiotherapy plus cetuximab or cisplatin in human papillomavirus-positive oropharyngeal cancer (NRG Oncology RTOG 1016): a randomised, multicentre, non-inferiority trial.
Academic Article Efficacy of Anti-HER2 Agents in Combination With Adjuvant or Neoadjuvant Chemotherapy for Early and Locally Advanced HER2-Positive Breast Cancer Patients: A Network Meta-Analysis.
Academic Article Smoking, age, nodal disease, T stage, p16 status, and risk of distant metastases in patients with squamous cell cancer of the oropharynx.
Academic Article Event-Free Survival, a Prostate-Specific Antigen-Based Composite End Point, Is Not a Surrogate for Overall Survival in Men With Localized Prostate Cancer Treated With Radiation.
Academic Article Characteristics of Participation in Patient-Reported Outcomes and Electronic Data Capture Components of NRG Oncology Clinical Trials.
Academic Article Multicenter Clinical Cancer Research After COVID-19: A Perspective From NRG Oncology.
Academic Article Disparities in Breast Cancer: Narrowing the Gap.
Academic Article Statistical Considerations in the Evaluation of Continuous Biomarkers.
Academic Article Appropriate Systemic Therapy Dosing for Obese Adult Patients With Cancer: ASCO Guideline Update.
Academic Article Hematuria following Post-Prostatectomy Radiotherapy: Incidence Increases with Long-Term Followup.
Academic Article Predictors of Pneumonitis in Combined Thoracic Stereotactic Body Radiation Therapy and Immunotherapy.
Concept Pemetrexed
Concept Bevacizumab
Concept Cetuximab
Concept Tobacco Smoking
Concept Betacoronavirus
Academic Article Risk Factors for Hospital Readmission in Patients with Interstitial Lung Disease.
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