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Dulin, Nickolai
One or more keywords matched the following properties of Dulin, Nickolai
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overview Dr. Dulin’s laboratory investigates the signaling mechanisms of TGF-beta-induced myofibroblast differentiation as related to pathogenesis of pulmonary fibrosis, using cell culture and animal models of the disease. His studies have described the critical role for serum response factor (SRF) in myofibroblast differentiation and pulmonary fibrosis, as well as the control of this pathway by actin and microtubule dynamics. The other direction of Dr. Dulin research relates to the basic studies on the biological function of the regulators of G protein signaling (RGS) proteins, focusing on RGS3 member of the family. His group has shown that RGS3 regulates the signaling mediated by heterotrimeric Gi and Gq proteins, as well as non-canonically of TGF-beta signaling. Together with Dr. Anne Sperling, they established the role of RGS3 in control of T cell migration and T cell – mediated inflammation, using knock-down and knockout approaches. His current studies focus on the function of endogenous RGS3 as related to cancer cell growth, migration and EMT. Dr. Dulin's NIH Commons ID is NDULIN
One or more keywords matched the following items that are connected to Dulin, Nickolai
Item TypeName
Concept Platelet-Derived Growth Factor
Concept Tumor Necrosis Factor-alpha
Concept Transforming Growth Factor beta
Concept TNF Receptor-Associated Factor 6
Concept Receptor, Fibroblast Growth Factor, Type 1
Concept Transforming Growth Factor beta1
Concept Transforming Growth Factor beta2
Concept TNF Receptor-Associated Factor 2
Concept Serum Response Factor
Concept Vascular Endothelial Growth Factor A
Concept Fibroblast Growth Factor 2
Concept Receptors, Platelet-Derived Growth Factor
Concept Receptors, Transforming Growth Factor beta
Concept Transforming Growth Factor beta3
Academic Article Crk protein binds to PDGF receptor and insulin receptor substrate-1 with different modulating effects on PDGF- and insulin-dependent signaling pathways.
Academic Article Arachidonate-induced tyrosine phosphorylation of epidermal growth factor receptor and Shc-Grb2-Sos association.
Academic Article Zinc inhibits nuclear factor-kappa B activation and sensitizes prostate cancer cells to cytotoxic agents.
Academic Article Fractalkine (CX3CL1) stimulated by nuclear factor kappaB (NF-kappaB)-dependent inflammatory signals induces aortic smooth muscle cell proliferation through an autocrine pathway.
Academic Article Functional significance of protein kinase A activation by endothelin-1 and ATP: negative regulation of SRF-dependent gene expression by PKA.
Academic Article Serum response factor function and dysfunction in smooth muscle.
Academic Article Dual role of PKA in phenotypic modulation of vascular smooth muscle cells by extracellular ATP.
Academic Article Renal carcinoma cells undergo apoptosis without oligonucleosomal DNA fragmentation.
Academic Article Regulation of serum response factor-dependent gene expression by proteasome inhibitors.
Academic Article SRF function in vascular smooth muscle: when less is more?
Academic Article Priming with very low-affinity peptide ligands gives rise to CD8(+) T-cell effectors with enhanced function but with greater susceptibility to transforming growth factor (TGF)ß-mediated suppression.
Academic Article Expression of cyclic guanosine monophosphate-dependent protein kinase in metastatic colon carcinoma cells blocks tumor angiogenesis.
Academic Article Delayed stress fiber formation mediates pulmonary myofibroblast differentiation in response to TGF-ß.
Academic Article Actin cytoskeleton in myofibroblast differentiation: ultrastructure defining form and driving function.
Academic Article Critical role of serum response factor in pulmonary myofibroblast differentiation induced by TGF-beta.
Academic Article Downregulation of smooth muscle alpha-actin expression by bacterial lipopolysaccharide.
Academic Article Regulation of Smad-mediated gene transcription by RGS3.
Academic Article Nuclear import of serum response factor in airway smooth muscle.
Academic Article Control of myofibroblast differentiation by microtubule dynamics through a regulated localization of mDia2.
Academic Article Regulation of myofibroblast differentiation and bleomycin-induced pulmonary fibrosis by adrenomedullin.
Academic Article SIRT3 blocks myofibroblast differentiation and pulmonary fibrosis by preventing mitochondrial DNA damage.
Academic Article Transforming Growth Factor (TGF)-ß Promotes de Novo Serine Synthesis for Collagen Production.
Academic Article Downregulation of TGF-ß Receptor-2 Expression and Signaling through Inhibition of Na/K-ATPase.
Academic Article Na+,K+-ATPase as a Target for Treatment of Tissue Fibrosis.
Academic Article Inhibition of Phosphoglycerate Dehydrogenase Attenuates Bleomycin-induced Pulmonary Fibrosis.
Academic Article P311 Promotes Lung Fibrosis via Stimulation of Transforming Growth Factor-ß1, -ß2, and -ß3 Translation.
Academic Article Fibroblast growth factor 2 decreases bleomycin-induced pulmonary fibrosis and inhibits fibroblast collagen production and myofibroblast differentiation.
Academic Article Sustained Smad2 Phosphorylation Is Required for Myofibroblast Transformation in Response to TGF-ß.
Academic Article Glutamine Metabolism Is Required for Collagen Protein Synthesis in Lung Fibroblasts.
Academic Article Anti-fibrotic effects of tannic acid through regulation of a sustained TGF-beta receptor signaling.
Academic Article Memory Precursors and Short-Lived Effector T cell Subsets Have Different Sensitivities to TGFß.
Grant Control of myofibroblast activation and pulmonary fibrosis by Na/K-ATPase
Academic Article Anoctamin-1 is induced by TGF-ß and contributes to lung myofibroblast differentiation.
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