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Ober, Carole
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overview The research goals of my laboratory are to identify genetic variants that influence gene expression and epigenetic marks in tissues relevant to complex phenotypes and common diseases, in particular those related to asthma, allergy and preterm birth. To this end we are using both freshly isolated cells and tissues and cell culture models of gene-environment interactions to dissect the genetic architecture of common diseases. Our studies are conducted in founder populations, the Hutterites of South Dakota and the Amish of northern Indiana, in U.S. and European birth cohorts, and in patient populations from Chicago.
One or more keywords matched the following items that are connected to Ober, Carole
Item TypeName
Concept Alleles
Concept Base Sequence
Concept Gene Frequency
Concept Gene Expression Regulation
Concept Genes, Dominant
Concept Genes, MHC Class II
Concept Genes, Lethal
Concept Genes, Recessive
Concept Genes, MHC Class I
Concept Multigene Family
Concept Molecular Sequence Data
Concept Major Histocompatibility Complex
Concept Pseudogenes
Concept Gene Expression
Concept Gene Deletion
Concept Gene Expression Regulation, Developmental
Concept Genes, X-Linked
Concept Gene Regulatory Networks
Concept Genes, T-Cell Receptor
Concept Genetic Pleiotropy
Concept Exome
Concept Gene-Environment Interaction
Concept Histone Code
Concept Gene Expression Profiling
Concept Open Reading Frames
Concept Genome, Human
Concept Genes, erbB-2
Concept Transcriptome
Concept Metagenome
Concept Epistasis, Genetic
Concept Conserved Sequence
Concept Polymorphism, Single Nucleotide
Concept Quantitative Trait Loci
Concept Genetic Loci
Academic Article HLA-G1 protein expression is not essential for fetal survival.
Academic Article Broad and narrow heritabilities of quantitative traits in a founder population.
Academic Article A null mutation in HLA-G is not associated with preeclampsia or intrauterine growth retardation.
Academic Article Variation in the HLA-G promoter region influences miscarriage rates.
Academic Article Sequence variation in the promoter region of the cholinergic receptor muscarinic 3 gene and asthma and atopy.
Academic Article Are common disease susceptibility alleles the same in outbred and founder populations?
Academic Article Genetic variation in immunoregulatory pathways and atopic phenotypes in infancy.
Academic Article Genome-wide association study identifies ITGB3 as a QTL for whole blood serotonin.
Academic Article Linkage disequilibrium and age estimates of a deletion polymorphism (1597DeltaC) in HLA-G suggest non-neutral evolution.
Academic Article Multilocus linkage disequilibrium mapping by the decay of haplotype sharing with samples of related individuals.
Academic Article ITGB3 shows genetic and expression interaction with SLC6A4.
Academic Article Evidence of balancing selection at the HLA-G promoter region.
Academic Article Heritability estimation of sex-specific effects on human quantitative traits.
Academic Article Best linear unbiased allele-frequency estimation in complex pedigrees.
Academic Article Sex-specific genetic architecture of human disease.
Academic Article CFTR mutations and reproductive outcomes in a population isolate.
Academic Article Genome-wide association study of plasma lipoprotein(a) levels identifies multiple genes on chromosome 6q.
Academic Article Sequencing the IL4 locus in African Americans implicates rare noncoding variants in asthma susceptibility.
Academic Article HLA-G and immune tolerance in pregnancy.
Academic Article Shades of gray: a comparison of linkage disequilibrium between Hutterites and Europeans.
Academic Article Gene-environment interactions in human disease: nuisance or opportunity?
Academic Article The genetics of asthma and allergic disease: a 21st century perspective.
Academic Article The effects of EBV transformation on gene expression levels and methylation profiles.
Academic Article Genetic analysis of HLA in the U.S. Schmiedenleut Hutterites.
Academic Article The combination of a genome-wide association study of lymphocyte count and analysis of gene expression data reveals novel asthma candidate genes.
Academic Article Genome-wide association study identifies candidate genes for male fertility traits in humans.
Academic Article Resequencing candidate genes implicates rare variants in asthma susceptibility.
Academic Article HLA-DQA1 and HLA-DQB1 haplotypes in aborted fetuses and couples with recurrent spontaneous abortion.
Academic Article Exome sequencing reveals a novel mutation for autosomal recessive non-syndromic mental retardation in the TECR gene on chromosome 19p13.
Academic Article A population-based study of autosomal-recessive disease-causing mutations in a founder population.
Academic Article HLA and mate choice in humans.
Academic Article Estimation of variance components of quantitative traits in inbred populations.
Academic Article Evidence for extensive transmission distortion in the human genome.
Academic Article Fine mapping and positional candidate studies identify HLA-G as an asthma susceptibility gene on chromosome 6p21.
Academic Article Gene-environment interaction effects on the development of immune responses in the 1st year of life.
Academic Article A genomewide screen for chronic rhinosinusitis genes identifies a locus on chromosome 7q.
Academic Article Rhinovirus wheezing illness and genetic risk of childhood-onset asthma.
Academic Article The maternal HLA-G 1597?C null mutation is associated with increased risk of pre-eclampsia and reduced HLA-G expression during pregnancy in African-American women.
Academic Article The CTLA-4 gene is expressed in placental fibroblasts.
Academic Article Genome-wide interaction studies reveal sex-specific asthma risk alleles.
Academic Article Effect of inbreeding avoidance on Hardy-Weinberg expectations: examples of neutral and selected loci.
Academic Article HLA-G polymorphisms: neutral evolution or novel function?
Academic Article Population genetic studies of HLA-G: allele frequencies and linkage disequilibrium with HLA-A1.
Academic Article Whole-genome sequencing of individuals from a founder population identifies candidate genes for asthma.
Academic Article The effect of freeze-thaw cycles on gene expression levels in lymphoblastoid cell lines.
Academic Article An estimate of the average number of recessive lethal mutations carried by humans.
Academic Article Evolutionary forward genomics reveals novel insights into the genes and pathways dysregulated in recurrent early pregnancy loss.
Academic Article Host genetic variation influences gene expression response to rhinovirus infection.
Academic Article Leveraging gene-environment interactions and endotypes for asthma gene discovery.
Academic Article Asthma Genetics in the Post-GWAS Era.
Academic Article Expression Quantitative Trait Locus Mapping Studies in Mid-secretory Phase Endometrial Cells Identifies HLA-F and TAP2 as Fecundability-Associated Genes.
Academic Article Innate Immunity and Asthma Risk in Amish and Hutterite Farm Children.
Academic Article Integrated analyses of gene expression and genetic association studies in a founder population.
Academic Article DNA methylation in lung cells is associated with asthma endotypes and genetic risk.
Grant Prenatal Origins of Asthma
Grant Mendelian Disease - Asthma Comorbidity to Find Subgroup-Specific Asthma Genes
Academic Article Parent of origin gene expression in a founder population identifies two new candidate imprinted genes at known imprinted regions.
Academic Article Effects of an Fc?RIIA polymorphism on leukocyte gene expression and cytokine responses to anti-CD3 and anti-CD28 antibodies.
Academic Article Global DNA methylation changes spanning puberty are near predicted estrogen-responsive genes and enriched for genes involved in endocrine and immune processes.
Academic Article Transcriptional programming and T cell receptor repertoires distinguish human lung and lymph node memory T cells.
Academic Article Expression quantitative trait locus fine mapping of the 17q12-21 asthma locus in African American children: a genetic association and gene expression study.
Academic Article Cytokine-induced molecular responses in airway smooth muscle cells inform genome-wide association studies of asthma.
Academic Article Transcriptome and regulatory maps of decidua-derived stromal cells inform gene discovery in preterm birth.
Academic Article Sex-specific differences in peripheral blood leukocyte transcriptional response to LPS are enriched for HLA region and X chromosome genes.
Academic Article Extensive pleiotropism and allelic heterogeneity mediate metabolic effects of IRX3 and IRX5.
Academic Article Multiethnic genome-wide and HLA association study of total serum IgE level.
Academic Article Multi-omics colocalization with genome-wide association studies reveals a context-specific genetic mechanism at a childhood onset asthma risk locus.
Academic Article Inducible expression quantitative trait locus analysis of the MUC5AC gene in asthma in urban populations of children.
Academic Article DNA methylation signatures in airway cells from adult children of asthmatic mothers reflect subtypes of severe asthma.
Academic Article Genome-wide association and multi-omics studies identify MGMT as a novel risk gene for Alzheimer's disease among women.
Concept Gene Ontology
Grant Airway inflammation and HLA-G in asthma
Grant Positional Cloning of a 6p-linked Asthma Gene
Grant Molecular Genetic Studies of Fertility in the Hutterites
Grant COLLABORATIVE STUDY OF THE GENETICS OF ASTHMA (CSGA)
Grant CHARACTERIZING A 5P-LINKED BHR SUSCEPTIBILITY LOCUS
Grant The EVE Asthma Genetics Consortium: Building Upon GWAS
Grant Genomic Studies of Sex-Specific Architecture of Asthma-Associated Traits
Grant THERAPIES FOR RECURRENT MISCARRIAGE: A RANDOMIZED STUDY
Academic Article Gene-based association study of rare variants in children of diverse ancestries implicates TNFRSF21 in the development of allergic asthma.
Search Criteria
  • Genes