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overview The research goals of my laboratory are to identify genetic variants that influence gene expression and epigenetic marks in tissues relevant to complex phenotypes and common diseases, in particular those related to asthma, allergy and preterm birth. To this end we are using both freshly isolated cells and tissues and cell culture models of gene-environment interactions to dissect the genetic architecture of common diseases. Our studies are conducted in founder populations, the Hutterites of South Dakota and the Amish of northern Indiana, in U.S. and European birth cohorts, and in patient populations from Chicago.
One or more keywords matched the following items that are connected to Ober, Carole
Item TypeName
Concept Phenotype
Academic Article Genetic variation in immunoregulatory pathways and atopic phenotypes in infancy.
Academic Article Heritability estimation of sex-specific effects on human quantitative traits.
Academic Article Variation in ITGB3 has sex-specific associations with plasma lipoprotein(a) and whole blood serotonin levels in a population-based sample.
Academic Article Integrin beta 3 genotype influences asthma and allergy phenotypes in the first 6 years of life.
Academic Article Genetic analysis of HLA in the U.S. Schmiedenleut Hutterites.
Academic Article Genome-wide association study identifies candidate genes for male fertility traits in humans.
Academic Article Effect of variation in CHI3L1 on serum YKL-40 level, risk of asthma, and lung function.
Academic Article Association studies for asthma and atopic diseases: a comprehensive review of the literature.
Academic Article Fine mapping and positional candidate studies identify HLA-G as an asthma susceptibility gene on chromosome 6p21.
Academic Article The effect of freeze-thaw cycles on gene expression levels in lymphoblastoid cell lines.
Academic Article Genome-wide association study of lung function phenotypes in a founder population.
Academic Article Leveraging gene-environment interactions and endotypes for asthma gene discovery.
Academic Article Expression Quantitative Trait Locus Mapping Studies in Mid-secretory Phase Endometrial Cells Identifies HLA-F and TAP2 as Fecundability-Associated Genes.
Academic Article Integrated analyses of gene expression and genetic association studies in a founder population.
Academic Article A decade of research on the 17q12-21 asthma locus: Piecing together the puzzle.
Academic Article Multiancestry association study identifies new asthma risk loci that colocalize with immune-cell enhancer marks.
Academic Article Parent-of-origin effects on quantitative phenotypes in a large Hutterite pedigree.
Academic Article Associations between fungal and bacterial microbiota of airways and asthma endotypes.
Academic Article T-cell phenotypes are associated with serum IgE levels in Amish and Hutterite children.
Academic Article Associations of autozygosity with a broad range of human phenotypes.
Academic Article Parent-of-origin effects on quantitative phenotypes in a large Hutterite pedigree.
Academic Article Cytokine-induced molecular responses in airway smooth muscle cells inform genome-wide association studies of asthma.
Academic Article Chromosome 17q12-21 Variants Are Associated with Multiple Wheezing Phenotypes in Childhood.
Academic Article Discerning asthma endotypes through comorbidity mapping.
Grant Airway inflammation and HLA-G in asthma
Grant Molecular Genetic Studies of Fertility in the Hutterites
Grant Training of Junior Faculty for Careers in Omics of Lung Diseases
Grant The EVE Asthma Genetics Consortium: Building Upon GWAS
Grant Genomic Studies of Sex-Specific Architecture of Asthma-Associated Traits
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  • Phenotype