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Ober, Carole
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overview The research goals of my laboratory are to identify genetic variants that influence gene expression and epigenetic marks in tissues relevant to complex phenotypes and common diseases, in particular those related to asthma, allergy and preterm birth. To this end we are using both freshly isolated cells and tissues and cell culture models of gene-environment interactions to dissect the genetic architecture of common diseases. Our studies are conducted in founder populations, the Hutterites of South Dakota and the Amish of northern Indiana, in U.S. and European birth cohorts, and in patient populations from Chicago.
One or more keywords matched the following items that are connected to Ober, Carole
Item TypeName
Concept Genetics, Population
Concept Population Surveillance
Concept Rural Population
Concept Urban Population
Concept Population Groups
Concept Population
Academic Article Broad and narrow heritabilities of quantitative traits in a founder population.
Academic Article A second-generation genomewide screen for asthma-susceptibility alleles in a founder population.
Academic Article Novel case-control test in a founder population identifies P-selectin as an atopy-susceptibility locus.
Academic Article Are common disease susceptibility alleles the same in outbred and founder populations?
Academic Article The genetic dissection of complex traits in a founder population.
Academic Article Evidence of balancing selection at the HLA-G promoter region.
Academic Article CFTR mutations and reproductive outcomes in a population isolate.
Academic Article Variation in ITGB3 has sex-specific associations with plasma lipoprotein(a) and whole blood serotonin levels in a population-based sample.
Academic Article Drawing the history of the Hutterite population on a genetic landscape: inference from Y-chromosome and mtDNA genotypes.
Academic Article Colloquium papers: Heritability of reproductive fitness traits in a human population.
Academic Article Shades of gray: a comparison of linkage disequilibrium between Hutterites and Europeans.
Academic Article The sex-specific genetic architecture of quantitative traits in humans.
Academic Article Meta-analysis of genome-wide association studies of asthma in ethnically diverse North American populations.
Academic Article Accurate imputation of rare and common variants in a founder population from a small number of sequenced individuals.
Academic Article Estimating the human mutation rate using autozygosity in a founder population.
Academic Article Sex-specific genetic architecture of asthma-associated quantitative trait loci in a founder population.
Academic Article Rising prevalence of asthma is sex-specific in a US farming population.
Academic Article A population-based study of autosomal-recessive disease-causing mutations in a founder population.
Academic Article Estimation of variance components of quantitative traits in inbred populations.
Academic Article Variation in ITGB3 is associated with asthma and sensitization to mold allergen in four populations.
Academic Article A genomewide screen for chronic rhinosinusitis genes identifies a locus on chromosome 7q.
Academic Article The CFTR Met 470 allele is associated with lower birth rates in fertile men from a population isolate.
Academic Article A meta-analysis of genome-wide association studies for serum total IgE in diverse study populations.
Academic Article Population genetic studies of HLA-E: evidence for selection.
Academic Article Population genetic studies of HLA-G: allele frequencies and linkage disequilibrium with HLA-A1.
Academic Article Whole-genome sequencing of individuals from a founder population identifies candidate genes for asthma.
Academic Article PRIMAL: Fast and accurate pedigree-based imputation from sequence data in a founder population.
Academic Article Genome-wide association study of lung function phenotypes in a founder population.
Academic Article Integrated analyses of gene expression and genetic association studies in a founder population.
Academic Article Rare non-coding variants are associated with plasma lipid traits in a founder population.
Academic Article Parent of origin gene expression in a founder population identifies two new candidate imprinted genes at known imprinted regions.
Academic Article Immune development and environment: lessons from Amish and Hutterite children.
Academic Article Author Correction: Association study in African-admixed populations across the Americas recapitulates asthma risk loci in non-African populations.
Academic Article Inducible expression quantitative trait locus analysis of the MUC5AC gene in asthma in urban populations of children.
Grant Positional Cloning of a 6p-linked Asthma Gene
Grant Molecular Genetic Studies of Fertility in the Hutterites
Grant COLLABORATIVE STUDY OF THE GENETICS OF ASTHMA (CSGA)
Grant CHARACTERIZING A 5P-LINKED BHR SUSCEPTIBILITY LOCUS
Grant The EVE Asthma Genetics Consortium: Building Upon GWAS
Grant Genomic Studies of Sex-Specific Architecture of Asthma-Associated Traits
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  • Population