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One or more keywords matched the following properties of Wei, Wei
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keywords neural circuit, neural computation, synaptic physiology, retina, motion detection, visual processing
overview How are neural circuits assembled to perform specific computations? An excellent model system to address this question is the retina, where a diverse set of neural circuits are wired with remarkable precision and intricacy to extract salient features such as color, contrast and motion from the visual scene. Each retinal circuit utilizes distinct neuronal types and conveys the processed visual information to higher brain by a specific type of retinal ganglion cells. My lab is interested in the synaptic basis of neural computation in the retina. Our current research is focused on understanding the developmental and adult patterns of synaptic connections underlying the retinal circuits, and determining how the specific wiring patterns impact visual processing. We leverage the increasing repertoire of genetic tools that label specific retinal neuron types to target the synapses of interest, and characterize the maturation and function of these synapses using a combination of techniques including multiphoton microscopy, visual stimulation, electrophysiology and molecular biology. These studies will provide insight into the neural mechanisms of visual processing in the retina, and also have broader implications in the fundamental questions of synapse development and organization in the central nervous system.
One or more keywords matched the following items that are connected to Wei, Wei
Item TypeName
Concept Retina
Academic Article Organization and development of direction-selective circuits in the retina.
Academic Article Conditional Knock-Out of Vesicular GABA Transporter Gene from Starburst Amacrine Cells Reveals the Contributions of Multiple Synaptic Mechanisms Underlying Direction Selectivity in the Retina.
Academic Article Transgenic mice reveal unexpected diversity of on-off direction-selective retinal ganglion cell subtypes and brain structures involved in motion processing.
Academic Article Development of asymmetric inhibition underlying direction selectivity in the retina.
Academic Article Two-photon targeted recording of GFP-expressing neurons for light responses and live-cell imaging in the mouse retina.
Academic Article Stimulus-dependent recruitment of lateral inhibition underlies retinal direction selectivity.
Academic Article Retinal origin of direction selectivity in the superior colliculus.
Academic Article Neural Mechanisms of Motion Processing in the Mammalian Retina.
Academic Article Stimulus-dependent engagement of neural mechanisms for reliable motion detection in the mouse retina.
Academic Article Compartmentalized dendritic signaling in a multitasking retinal interneuron.
Academic Article Cross-compartmental Modulation of Dendritic Signals for Retinal Direction Selectivity.
Academic Article Decreasing Influence of Retinal Inputs on the Developing Visual Cortex.
Academic Article Preserving inhibition with a disinhibitory microcircuit in the retina.
Grant Circuit mechanisms for encoding naturalistic motion in the mammalian retina
Grant Synaptic basis of motion detection in the retina
Academic Article Visual stimulation induces distinct forms of sensitization of On-Off direction-selective ganglion cell responses in the dorsal and ventral retina
Academic Article Functional convergence of on-off direction-selective ganglion cells in the visual thalamus.
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  • Retina