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Prabhakar, Nanduri
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overview Dr. Prabhakar notes that the revolutionary advances in cell and molecular biology, as well as in genetic engineering over the past half-century, have provided remarkable insights into the structure and function of biological systems at the molecular, cellular, and sub-cellular levels. He observes that the shift in research emphasis from organ-level (or whole-body) studies to cellular and molecular physiology has coincided with a rapid decline in systems-level physiological research. While acknowledging the power of reductionist approaches, Dr. Prabhakar highlights the significant gap that has emerged between our understanding of molecular and cellular changes and their effects at the organ or whole-animal level. According to Dr. Prabhakar, integrative physiology addresses this gap by incorporating concepts from cell and molecular physiology and biochemistry, applying them to understand function at the level of the whole animal or organ. Recognizing the importance of this approach, the University of Chicago established the Institute for Integrative Physiology (IIP) within the Biological Sciences Division in October 2010. Dr. Prabhakar explains that the IIP was created to serve as an intellectual hub for faculty engaged in diverse areas of physiology, to promote collaborative research initiatives, and to oversee physiology education for medical, graduate, and undergraduate students. These objectives are supported by the IIP’s distinguished faculty. Dr. Prabhakar believes that the IIP extends well beyond the Biological Sciences Division to elevate the national and international visibility of physiological research at the University of Chicago and to train the next generation of leaders in the field. Nanduri R. Prabhakar, Ph.D., D.Sc. Harold Hines Jr. Professor of Medicine Director, Center for Systems Biology Director, Oxygen Sensing Department of Medicine
One or more keywords matched the following items that are connected to Prabhakar, Nanduri
Item TypeName
Concept Oxygen Consumption
Concept Oxygen
Concept Reactive Oxygen Species
Academic Article Cell selective induction and transcriptional activation of immediate early genes by hypoxia.
Academic Article Regulation of neuronal nitric oxide synthase gene expression by hypoxia. Role of nitric oxide in respiratory adaptation to low pO2.
Academic Article G proteins in carotid body chemoreception.
Academic Article NO and CO as second messengers in oxygen sensing in the carotid body.
Academic Article Nitric oxide and ventilatory response to hypoxia.
Academic Article Involvement of substance P in neutral endopeptidase modulation of carotid body sensory responses to hypoxia.
Academic Article Dual influence of nitric oxide on gene regulation during hypoxia.
Academic Article Oxygen sensing by the carotid body chemoreceptors.
Academic Article Release of dopamine and norepinephrine by hypoxia from PC-12 cells.
Academic Article Neural drives and breathing stability.
Academic Article CO2/HCO3- modulates K+ and Ca2+ currents in glomus cells of the carotid body.
Academic Article Chronic intermittent hypoxia enhances carotid body chemoreceptor response to low oxygen.
Academic Article Sleep apneas: an oxidative stress?
Academic Article Blunted respiratory responses to hypoxia in mutant mice deficient in nitric oxide synthase-3.
Academic Article Ventilatory changes during intermittent hypoxia: importance of pattern and duration.
Academic Article Cellular mechanisms of oxygen sensing at the carotid body: heme proteins and ion channels.
Academic Article Oxygen sensing during intermittent hypoxia: cellular and molecular mechanisms.
Academic Article Mutant mice deficient in NOS-1 exhibit attenuated long-term facilitation and short-term potentiation in breathing.
Academic Article Peripheral and central chemosensitivity: multiple mechanisms, multiple sites? A workshop summary.
Academic Article Tachykinins in the control of breathing by hypoxia: pre- and post-genomic era.
Academic Article Gene regulation during intermittent hypoxia: evidence for the involvement of reactive oxygen species.
Academic Article Reactive oxygen species in the plasticity of respiratory behavior elicited by chronic intermittent hypoxia.
Academic Article Release of substance P by low oxygen in the rabbit carotid body: evidence for the involvement of calcium channels.
Academic Article Peripheral chemoreceptors in health and disease.
Academic Article Detection of oxygen sensing during intermittent hypoxia.
Academic Article Impaired ventilatory acclimatization to hypoxia in mice lacking the immediate early gene fos B.
Academic Article Cellular and molecular mechanisms associated with carotid body adaptations to chronic hypoxia.
Academic Article Systemic, cellular and molecular analysis of chemoreflex-mediated sympathoexcitation by chronic intermittent hypoxia.
Academic Article Regulation of breathing by tissue oxygen: evidence from mutant mice with Presbyterian hemoglobinopathy.
Academic Article Altered carotid body function by intermittent hypoxia in neonates and adults: relevance to recurrent apneas.
Academic Article Heterozygous HIF-1alpha deficiency impairs carotid body-mediated systemic responses and reactive oxygen species generation in mice exposed to intermittent hypoxia.
Academic Article ROS signaling in systemic and cellular responses to chronic intermittent hypoxia.
Academic Article Increased secretory capacity of mouse adrenal chromaffin cells by chronic intermittent hypoxia: involvement of protein kinase C.
Academic Article Induction of HIF-1alpha expression by intermittent hypoxia: involvement of NADPH oxidase, Ca2+ signaling, prolyl hydroxylases, and mTOR.
Academic Article Transcriptional responses to intermittent hypoxia.
Academic Article Role of oxidative stress in intermittent hypoxia-induced immediate early gene activation in rat PC12 cells.
Academic Article Role of substance P in hypercapnic excitation of carotid chemoreceptors.
Academic Article Intermittent hypoxia activates peptidylglycine alpha-amidating monooxygenase in rat brain stem via reactive oxygen species-mediated proteolytic processing.
Academic Article Pattern-specific sustained activation of tyrosine hydroxylase by intermittent hypoxia: role of reactive oxygen species-dependent downregulation of protein phosphatase 2A and upregulation of protein kinases.
Academic Article NADPH oxidase is required for the sensory plasticity of the carotid body by chronic intermittent hypoxia.
Academic Article Hypoxia inhibits maturation and trafficking of hERG K(+) channel protein: Role of Hsp90 and ROS.
Academic Article O2 sensing at the mammalian carotid body: why multiple O2 sensors and multiple transmitters?
Academic Article Neonatal intermittent hypoxia leads to long-lasting facilitation of acute hypoxia-evoked catecholamine secretion from rat chromaffin cells.
Academic Article H2S mediates O2 sensing in the carotid body.
Academic Article Sensing hypoxia: carotid body mechanisms and reflexes in health and disease.
Academic Article NADPH oxidase 2 mediates intermittent hypoxia-induced mitochondrial complex I inhibition: relevance to blood pressure changes in rats.
Academic Article Intermittent hypoxia augments acute hypoxic sensing via HIF-mediated ROS.
Academic Article Cellular mechanisms associated with intermittent hypoxia.
Academic Article Sensory plasticity of the carotid body: role of reactive oxygen species and physiological significance.
Academic Article The role of hypoxia-inducible factors in oxygen sensing by the carotid body.
Academic Article Mitochondrial reactive oxygen species mediate hypoxic down-regulation of hERG channel protein.
Academic Article Oxygen sensing in the body.
Academic Article Reactive oxygen species-dependent endothelin signaling is required for augmented hypoxic sensory response of the neonatal carotid body by intermittent hypoxia.
Academic Article Effect of arterial chemoreceptor stimulation: role of norepinephrine in hypoxic chemotransmission.
Academic Article Contrasting effects of intermittent and continuous hypoxia on low O(2) evoked catecholamine secretion from neonatal rat chromaffin cells.
Academic Article Substance P and neurokinin A in the cat carotid body: localization, exogenous effects and changes in content in response to arterial pO2.
Academic Article Substance P and mitochondrial oxygen consumption: evidence for a direct intracellular role for the peptide.
Academic Article Enhanced neuropeptide Y synthesis during intermittent hypoxia in the rat adrenal medulla: role of reactive oxygen species-dependent alterations in precursor peptide processing.
Academic Article Hypoxia-inducible factor 1 mediates increased expression of NADPH oxidase-2 in response to intermittent hypoxia.
Academic Article Role of adenosine in hypoxic ventilatory depression.
Academic Article Differential regulation of tyrosine hydroxylase by continuous and intermittent hypoxia.
Academic Article Hypoxia-inducible factor 2a (HIF-2a) heterozygous-null mice exhibit exaggerated carotid body sensitivity to hypoxia, breathing instability, and hypertension.
Academic Article Angiotensin II evokes sensory long-term facilitation of the carotid body via NADPH oxidase.
Academic Article Endothelin-1 mediates attenuated carotid baroreceptor activity by intermittent hypoxia.
Academic Article Gas biology: small molecular medicine.
Academic Article Novel role for reactive oxygen species as amplifiers of intermittent hypoxia. Focus on "Reactive oxygen species mediate central cardiorespiratory network responses to acute intermittent hypoxia".
Academic Article Nitric oxide in the sensory function of the carotid body.
Academic Article Adaptive and maladaptive cardiorespiratory responses to continuous and intermittent hypoxia mediated by hypoxia-inducible factors 1 and 2.
Academic Article Low PO2 dependency of neutral endopeptidase and acetylcholinesterase activities of the rat carotid body.
Academic Article Role of substance P in rat carotid body responses to hypoxia and capsaicin.
Academic Article Selective blockade of sensory response of the carotid body to hypoxia by NK-1 receptor antagonist CP-96,345.
Academic Article Intermittent hypoxia-mediated plasticity of acute O2 sensing requires altered red-ox regulation by HIF-1 and HIF-2.
Academic Article Altered respiratory responses to hypoxia in mutant mice deficient in neuronal nitric oxide synthase.
Academic Article Cardiorespiratory changes induced by vertebral artery injection of sodium cyanide in cats.
Academic Article Role of nitric oxide in short-term potentiation and long-term facilitation: involvement of NO in breathing stability.
Academic Article Facilitation of dopamine and acetylcholine release by intermittent hypoxia in PC12 cells: involvement of calcium and reactive oxygen species.
Academic Article Ca2+/calmodulin kinase-dependent activation of hypoxia inducible factor 1 transcriptional activity in cells subjected to intermittent hypoxia.
Academic Article Kv1.1 deletion augments the afferent hypoxic chemosensory pathway and respiration.
Academic Article Reactive oxygen species facilitate oxygen sensing.
Academic Article Neonatal intermittent hypoxia impairs neuronal nicotinic receptor expression and function in adrenal chromaffin cells.
Academic Article Gaseous messengers in oxygen sensing.
Academic Article Developmental programming of O(2) sensing by neonatal intermittent hypoxia via epigenetic mechanisms.
Academic Article Peripheral chemoreceptors: function and plasticity of the carotid body.
Academic Article Mutual antagonism between hypoxia-inducible factors 1a and 2a regulates oxygen sensing and cardio-respiratory homeostasis.
Academic Article Inherent variations in CO-H2S-mediated carotid body O2 sensing mediate hypertension and pulmonary edema.
Academic Article Gasotransmitter regulation of ion channels: a key step in O2 sensing by the carotid body.
Academic Article Impairment of pancreatic ß-cell function by chronic intermittent hypoxia.
Academic Article CaV3.2 T-type Ca²? channels in H2S-mediated hypoxic response of the carotid body.
Academic Article Intermittent hypoxia-induced endothelial barrier dysfunction requires ROS-dependent MAP kinase activation.
Academic Article Xanthine oxidase mediates hypoxia-inducible factor-2a degradation by intermittent hypoxia.
Academic Article Neuromolecular mechanisms mediating the effects of chronic intermittent hypoxia on adrenal medulla.
Academic Article Peripheral chemoreception and arterial pressure responses to intermittent hypoxia.
Academic Article Protein kinase G-regulated production of H2S governs oxygen sensing.
Academic Article The human carotid body releases acetylcholine, ATP and cytokines during hypoxia.
Academic Article Epigenetic Regulation of Carotid Body Oxygen Sensing: Clinical Implications.
Academic Article Oxygen Sensing and Homeostasis.
Academic Article Regulation of carotid body oxygen sensing by hypoxia-inducible factors.
Academic Article CaV3.2 T-type Ca2+ channels mediate the augmented calcium influx in carotid body glomus cells by chronic intermittent hypoxia.
Academic Article Calpain activation by ROS mediates human ether-a-go-go-related gene protein degradation by intermittent hypoxia.
Academic Article H2S production by reactive oxygen species in the carotid body triggers hypertension in a rodent model of sleep apnea.
Academic Article Epigenetic regulation of redox state mediates persistent cardiorespiratory abnormalities after long-term intermittent hypoxia.
Academic Article Systems biology of oxygen homeostasis.
Academic Article Oxygen Sensing by the Carotid Body: Past and Present.
Academic Article Reactive oxygen radicals and gaseous transmitters in carotid body activation by intermittent hypoxia.
Academic Article The role of hypoxia-inducible factors in carotid body (patho) physiology.
Academic Article Immunohistochemistry of the Carotid Body.
Academic Article DNA methylation in the central and efferent limbs of the chemoreflex requires carotid body neural activity.
Academic Article Hypoxia induced hERG trafficking defect linked to cell cycle arrest in SH-SY5Y cells.
Award or Honor Receipt Nobel Forum: Invited Speaker, Nobel Symposium on Oxygen Biology, Stockholm Sweden
Academic Article Olfactory receptor 78 participates in carotid body response to a wide range of low O2 levels but not severe hypoxia.
Academic Article Hypoxia-inducible factors and obstructive sleep apnea.
Academic Article Hypoxia-inducible factor-1 mediates pancreatic ß-cell dysfunction by intermittent hypoxia.
Academic Article Lysine demethylase KDM6B regulates HIF-1a-mediated systemic and cellular responses to intermittent hypoxia.
Academic Article Protein phosphatase 1 regulates reactive oxygen species-dependent degradation of histone deacetylase 5 by intermittent hypoxia.
Academic Article Carotid body responses to O2 and CO2 in hypoxia-tolerant naked mole rats.
Academic Article Adaptive cardiorespiratory changes to chronic continuous and intermittent hypoxia.
Academic Article Hypoxia sensing requires H2S-dependent persulfidation of olfactory receptor 78.
Academic Article Reactive Oxygen species dependent increase in H3K27 acetylation by intermittent hypoxia is regulated by H3S28 phosphorylation.
Grant Consequences of Neonatal Hypoxia
Grant GENE REGULATION DURING INTERMITTENT HYPOXIA
Grant The Training in Oxygen in Health and Disease
Grant Transmitters in Altered Carotid Body Function
Search Criteria
  • Oxygen