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overview Walter L. Palmer Distinguished Service Professor of Medicine and Pediatrics Dean for Translational Medicine Director, Institute for Translational Medicine I am Dean for Translational Medicine and founding Director of the Institute for Translational Medicine, home of the University of Chicago-Rush University NIH/NCATS CTSA award. I have served the CTSA Consortium as a co-Chair, Steering Committee member, and co-Chair of the Strategic Goal 3 and Collaboration/Engagement Domain Task Force. My research programs primarily address asthma. I have extensive experience studying airway smooth muscle (ASM) function and dysfunction in asthma, having studied smooth muscle specific gene transcription, protein accumulation, and hypertrophy, and signaling mechanisms that regulate these; ASM contraction and its reversal, and the mechanisms that regulate these; and ASM mediated-airway narrowing, airway constrictor responsiveness, and lung function in both animal models and humans. Additional studies address asthma genetics and therapeutics in mechanistic and therapeutic clinical studies and preclinical development of novel asthma treatments. Recently, I have focused on the inhibition of pulmonary fibrosis and on the inhibition of breast cancer metastasis using novel small molecules discovered in our asthma studies. I directed the University of Chicago's NHLBI-sponsored T32 Research Training Program in Respiratory Biology for 25 years, led or co-led two NHLBI Multidisciplinary K12 Training Programs, co-led an NIH Broadening Experiences in Scientific Training (BEST) award, and currently lead a Burroughs Wellcome Fund Physician Scientist Institutional Award. My ORCID is 0000-0002-0898-8530. My Scopus ID is 7006796752. My NIH COMMONS name is jsolway. BS 1974 Massachusetts Institute of Technology (Electrical Engineering) MD cum laude 1978 Harvard University (Medicine) Residency 1981 Brigham and Women's Hospital (Internal Medicine) Fellowship 1983 Harvard Medical School (Pulmonary Medicine)
Person ID 1704
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Concept Acute Disease
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Academic Article Developmental pattern of expression and genomic organization of the calponin-h1 gene. A contractile smooth muscle cell marker.
Academic Article 2A3 and 3F9. Novel lung epithelial antigens with early upregulation in hyperoxic and radiation lung injury models.
Academic Article Differential tachykinin receptor subtype activation in capsaicin and KCl contractions of guinea pig trachealis.
Academic Article Tachykinin receptor antagonists inhibit hyperpnea-induced bronchoconstriction in guinea pigs.
Academic Article p172: An alveolar type II and Clara cell specific protein with late developmental expression and upregulation by hyperoxic lung injury.
Academic Article Activation of tracheal smooth muscle responsiveness by fMLP-treated HL-60 cells and neutrophils.
Academic Article Construction and uses of a concentric catheter for gas sampling in lung airways.
Academic Article Augmented muscarinic responsiveness caused by 5-lipoxygenase products secreted from alveolar macrophages in isolated-perfused rat lung.
Academic Article Perhaps airway smooth muscle dysfunction contributes to asthmatic bronchial hyperresponsiveness after all.
Academic Article Hyperoxia-induced airway remodeling in immature rats. Correlation with airway responsiveness.
Academic Article Sequence and structural analysis of feline interleukin-5 cDNA.
Academic Article Bronchoalveolar lavage fluid from asthmatic subjects is mitogenic for human airway smooth muscle.
Academic Article Expression and cytogenetic localization of the human SM22 gene (TAGLN).
Academic Article Gas dispersion in volume-cycled tube flow. II. Tracer bolus experiments.
Academic Article Transcriptional regulation of smooth muscle contractile apparatus expression.
Academic Article Ipratropium bromide increases the ability of the nose to warm and humidify air.
Academic Article Mutagenesis analysis of human SM22: characterization of actin binding.
Academic Article Hyperoxia-induced airway hyperresponsiveness and remodeling in immature rats.
Academic Article A technique to measure the ability of the human nose to warm and humidify air.
Academic Article What makes the airways contract abnormally? Is it inflammation?
Academic Article Physiological control of smooth muscle-specific gene expression through regulated nuclear translocation of serum response factor.
Academic Article Ethnic differences in asthma and associated phenotypes: collaborative study on the genetics of asthma.
Academic Article Activated eosinophils elicit substance P release from cultured dorsal root ganglion neurons.
Academic Article Divergent differentiation paths in airway smooth muscle culture: induction of functionally contractile myocytes.
Academic Article Genome-wide linkage analyses of total serum IgE using variance components analysis in asthmatic families.
Academic Article Variation in the interleukin 4-receptor alpha gene confers susceptibility to asthma and atopy in ethnically diverse populations.
Academic Article Fas cross-linking induces apoptosis in human airway smooth muscle cells.
Academic Article The nasal passage of subjects with asthma has a decreased ability to warm and humidify inspired air.
Academic Article beta(2)-adrenergic receptor Arg16/Arg16 genotype is associated with reduced lung function, but not with asthma, in the Hutterites.
Academic Article Selective restoration of calcium coupling to muscarinic M(3) receptors in contractile cultured airway myocytes.
Academic Article Genomewide screen and identification of gene-gene interactions for asthma-susceptibility loci in three U.S. populations: collaborative study on the genetics of asthma.
Academic Article Sensory neuropeptides and airway function.
Academic Article Molecular mechanisms of phenotypic plasticity in smooth muscle cells.
Academic Article HLA-DRB1*01 alleles are associated with sensitization to cockroach allergens.
Academic Article Clinical practice. Mild asthma.
Academic Article Supine position decreases the ability of the nose to warm and humidify air.
Academic Article Natural and induced allergic responses increase the ability of the nose to warm and humidify air.
Academic Article Actin dynamics: a potential integrator of smooth muscle (Dys-)function and contractile apparatus gene expression in asthma. Parker B. Francis lecture.
Academic Article Sequence variation in the promoter region of the cholinergic receptor muscarinic 3 gene and asthma and atopy.
Academic Article Functional significance of protein kinase A activation by endothelin-1 and ATP: negative regulation of SRF-dependent gene expression by PKA.
Academic Article Lymphotoxin is required for maintaining physiological levels of serum IgE that minimizes Th1-mediated airway inflammation.
Academic Article Serum response factor function and dysfunction in smooth muscle.
Academic Article Do inflammatory mediators influence the contribution of airway smooth muscle contraction to airway hyperresponsiveness in asthma?
Academic Article A genome-wide search for allergic response (atopy) genes in three ethnic groups: Collaborative Study on the Genetics of Asthma.
Academic Article Rhinovirus 16 3C protease induces interleukin-8 and granulocyte-macrophage colony-stimulating factor expression in human bronchial epithelial cells.
Academic Article Treatment of nasal inflammation decreases the ability of subjects with asthma to condition inspired air.
Academic Article Structure and transcription of the human m3 muscarinic receptor gene.
Academic Article Human bronchial smooth muscle cell lines show a hypertrophic phenotype typical of severe asthma.
Academic Article The use and misuse of Penh in animal models of lung disease.
Academic Article Methodologic advancements in the study of airway smooth muscle.
Academic Article Can we differentiate between airway and vascular smooth muscle?
Academic Article What evidence implicates airway smooth muscle in the cause of BHR?
Academic Article Role of tachykinins in hyperpnea-induced bronchovascular hyperpermeability in guinea pigs.
Academic Article The RhoA/Rho kinase pathway regulates nuclear localization of serum response factor.
Academic Article Time course of bronchoconstriction induced by dry gas hyperpnea in guinea pigs.
Academic Article Functional characterization of evolutionarily conserved DNA regions in forkhead box f1 gene locus.
Academic Article SRF function in vascular smooth muscle: when less is more?
Academic Article Tidal breathing pattern differentially antagonizes bronchoconstriction in C57BL/6J vs. A/J mice.
Academic Article Breathing pattern affects respiratory heat loss but not bronchoconstrictor response in asthma.
Academic Article Expression cloning identifies transgelin (SM22) as a novel repressor of 92-kDa type IV collagenase (MMP-9) expression.
Academic Article Inhibition of transforming growth factor beta-enhanced serum response factor-dependent transcription by SMAD7.
Academic Article Inhibition of Th2-mediated allergic airway inflammatory disease by CD137 costimulation.
Academic Article Elevation of the nasal mucosal surface temperature after warming of the feet occurs via a neural reflex.
Academic Article Latrunculin B increases force fluctuation-induced relengthening of ACh-contracted, isotonically shortened canine tracheal smooth muscle.
Academic Article Airway smooth muscle as a target for asthma therapy.
Academic Article Airway smooth muscle dynamics: a common pathway of airway obstruction in asthma.
Academic Article Signaling through Fc gamma RIII is required for optimal T helper type (Th)2 responses and Th2-mediated airway inflammation.
Academic Article Distribution of airway narrowing during hyperpnea-induced bronchoconstriction in guinea pigs.
Academic Article Gene-environment interactions in a mutant mouse kindred with native airway constrictor hyperresponsiveness.
Academic Article On the terminology for describing the length-force relationship and its changes in airway smooth muscle.
Academic Article Effects of surface tension and viscosity on airway reopening.
Academic Article Airway smooth muscle in asthma.
Academic Article Myosin, transgelin, and myosin light chain kinase: expression and function in asthma.
Academic Article Disrupting actin-myosin-actin connectivity in airway smooth muscle as a treatment for asthma?
Academic Article p70 Ribosomal S6 kinase is required for airway smooth muscle cell size enlargement but not increased contractile protein expression.
Academic Article Lysophosphatidic acid enhances pulmonary epithelial barrier integrity and protects endotoxin-induced epithelial barrier disruption and lung injury.
Academic Article MEK modulates force-fluctuation-induced relengthening of canine tracheal smooth muscle.
Academic Article Transforming growth factor-beta1 and disorders of the lung.
Academic Article Fas-positive T cells regulate the resolution of airway inflammation in a murine model of asthma.
Academic Article Epithelium-dependent contraction of airway smooth muscle caused by eosinophil MBP.
Academic Article Differential induction of CD38 expression by TNF-{alpha} in asthmatic airway smooth muscle cells.
Academic Article Allele-specific targeting of microRNAs to HLA-G and risk of asthma.
Academic Article Force fluctuation-induced relengthening of acetylcholine-contracted airway smooth muscle.
Academic Article Kv7 potassium channels in airway smooth muscle cells: signal transduction intermediates and pharmacological targets for bronchodilator therapy.
Academic Article Gas density dependence of regional VA/V and VA/Q inequality during constant-flow ventilation.
Academic Article Tachykinins mediate bronchoconstriction elicited by isocapnic hyperpnea in guinea pigs.
Academic Article Genomic medicine and lung diseases.
Academic Article Genetic interactions between chromosomes 11 and 18 contribute to airway hyperresponsiveness in mice.
Academic Article Dilatation of the constricted human airway by tidal expansion of lung parenchyma.
Academic Article miR-140-3p regulation of TNF-a-induced CD38 expression in human airway smooth muscle cells.
Academic Article Lysophosphatidic acid-induced transactivation of epidermal growth factor receptor regulates cyclo-oxygenase-2 expression and prostaglandin E(2) release via C/EBPbeta in human bronchial epithelial cells.
Academic Article Dissociation of temperature-gradient and evaporative heat loss during cold gas hyperventilation in cold-induced asthma.
Academic Article Steroids augment relengthening of contracted airway smooth muscle: potential additional mechanism of benefit in asthma.
Academic Article Finite difference analysis of respiratory heat transfer.
Academic Article Thermal mapping of the airways in humans.
Academic Article Effect of bias flow rate on gas transport during high-frequency oscillatory ventilation.
Academic Article Intra-airway gas mixing during high-frequency ventilation.
Academic Article Bronchoalveolar lavage fluid from immature rats with hyperoxia-induced airway remodeling is mitogenic for airway smooth muscle.
Academic Article Immune sensitization augments epithelium-dependent spontaneous tone in guinea pig trachealis.
Academic Article Airway heat and water fluxes and the tracheobronchial circulation.
Academic Article The University of Chicago Institute for Translational Medicine.
Academic Article Longitudinal distribution of canine respiratory heat and water exchanges.
Academic Article Properties of steady maximal expiratory flow within excised canine central airways.
Academic Article Calcium channel blocking agents in bronchial hyperreactivity.
Academic Article Interdependent regional lung emptying during forced expiration: a transistor model.
Academic Article Circulatory heat sources for canine respiratory heat exchange.
Academic Article Differential inhibition of bronchoconstriction by the calcium channel blockers, verapamil and nifedipine.
Academic Article Impaired sensorineural function after allergen-induced mediator release.
Academic Article In vivo hyperoxic exposure increases cultured lung fibroblast proliferation and c-Ha-ras expression.
Academic Article Influences of parenchymal tethering on the reopening of closed pulmonary airways.
Academic Article Hyperoxia increases airway cell S-phase traversal in immature rats in vivo.
Academic Article Pressure, flow, and density relationships in airway models during constant-flow ventilation.
Academic Article Bronchoconstriction elicited by isocapnic hyperpnea in guinea pigs.
Academic Article Exposure of immature rats to hyperoxia increases tracheal smooth muscle stress generation in vitro.
Academic Article Akt activation induces hypertrophy without contractile phenotypic maturation in airway smooth muscle.
Academic Article Expiratory flow limitation and dynamic pulmonary hyperinflation during high-frequency ventilation.
Academic Article CO2 elimination by high-frequency oscillation: effects of vagosympathetic stimulation.
Academic Article Influence of cromolyn sodium on airway temperature in normal subjects.
Academic Article Biosynthesis of glycosylated hemoglobins in the monkey.
Academic Article Histamine antagonizes serotonin and growth factor-induced mitogen-activated protein kinase activation in bovine tracheal smooth muscle cells.
Academic Article Influence of the endotracheal tube on CO2 transport during high-frequency ventilation.
Academic Article Upstream stimulatory factor 1 activates GATA5 expression through an E-box motif.
Academic Article Airway reopening pressure in isolated rat lungs.
Academic Article Indirect assessment of mucosal surface temperatures in the airways: theory and tests.
Academic Article Pressure-flow relationships of endotracheal tubes during high-frequency ventilation.
Academic Article Persistent airway hyperresponsiveness and histologic alterations after chronic antigen challenge in cats.
Academic Article Proliferation of guinea pig tracheal epithelial cells induced by calcitonin gene-related peptide.
Academic Article Hydrogen peroxide stimulates mitogen-activated protein kinase in bovine tracheal myocytes: implications for human airway disease.
Academic Article Recovery of airway structure and function after hyperoxic exposure in immature rats.
Academic Article Ontogeny of dry gas hyperpnea-induced bronchoconstriction in guinea pigs.
Academic Article Endogenous sensory neuropeptide release enhances nonspecific airway responsiveness in guinea pigs.
Academic Article Role of eicosanoids in hyperpnea-induced airway responses in guinea pigs.
Academic Article Lung inflation during high-frequency ventilation.
Academic Article Hypertonicity, but not hypothermia, elicits substance P release from rat C-fiber neurons in primary culture.
Academic Article Proliferation of guinea pig tracheal epithelial cells in coculture with rat dorsal root ganglion neural cells.
Academic Article Structure and expression of a smooth muscle cell-specific gene, SM22 alpha.
Academic Article Structural and functional abnormalities of the airways of hyperoxia-exposed immature rats.
Academic Article Alternative promoter and GATA5 transcripts in mouse.
Academic Article Comparative study of intra-airway gas transport by alternative modes of ventilation.
Academic Article Bronchoconstrictor effects of leukotriene E4 in normal and asthmatic subjects.
Academic Article Air conditioning and exercise-induced asthma.
Academic Article Distribution of airway contractile responses within the major diameter bronchi during exogenous bronchoconstriction.
Academic Article Glycosylated minor components of human adult hemoglobin. Purification, identification, and partial structural analysis.
Academic Article Radiographic visualization of airway wall movement during oscillatory flow in dogs.
Academic Article Breathing pattern affects airway wall temperature during cold air hyperpnea in humans.
Academic Article Gas mixing during high-frequency ventilation: an improved model.
Academic Article Lung volume reduction surgery. This official statement of the American Thoracic Society was adopted by the ATS Board of Directors, May 1996.
Academic Article Pulmonary function in bronchopulmonary dysplasia.
Academic Article Phophatidylinositol-3 kinase/mammalian target of rapamycin/p70S6K regulates contractile protein accumulation in airway myocyte differentiation.
Academic Article Fine mapping and positional candidate studies identify HLA-G as an asthma susceptibility gene on chromosome 6p21.
Academic Article Variation in ITGB3 is associated with asthma and sensitization to mold allergen in four populations.
Academic Article Angiotensin I-converting enzyme mutation (Trp1197Stop) causes a dramatic increase in blood ACE.
Academic Article Nuclear import of serum response factor in airway smooth muscle.
Academic Article Lobar contribution to VA/Q inequality during constant-flow ventilation.
Academic Article Partitioning of pulmonary resistance during constriction in the dog: effects of volume history.
Academic Article Role of MAP kinase activation in bovine tracheal smooth muscle mitogenesis.
Academic Article Effect of airway inflammation on smooth muscle shortening and contractility in guinea pig trachealis.
Academic Article Preparedness of the CTSA's structural and scientific assets to support the mission of the National Center for Advancing Translational Sciences (NCATS).
Academic Article Emerging targets for novel therapy of asthma.
Academic Article The sharing partnership for innovative research in translation (SPIRiT) consortium: a model for collaboration across CTSA sites.
Academic Article Mechanical and structural plasticity.
Academic Article Airway smooth muscle in the pathophysiology and treatment of asthma.
Academic Article Maternal asthma and microRNA regulation of soluble HLA-G in the airway.
Academic Article Effect of vitamin D3 on asthma treatment failures in adults with symptomatic asthma and lower vitamin D levels: the VIDA randomized clinical trial.
Academic Article Stiffness-activated GEF-H1 expression exacerbates LPS-induced lung inflammation.
Academic Article Gata5 deficiency causes airway constrictor hyperresponsiveness in mice.
Academic Article Airway smooth muscle: a potential target for asthma therapy.
Academic Article E3 ubiquitin ligase Cbl-b suppresses proallergic T cell development and allergic airway inflammation.
Academic Article Airway contractility in the precision-cut lung slice after cryopreservation.
Academic Article A genome-wide survey of CD4(+) lymphocyte regulatory genetic variants identifies novel asthma genes.
Academic Article Genome-wide interrogation of longitudinal FEV1 in children with asthma.
Academic Article MicroRNA-146a and microRNA-146b expression and anti-inflammatory function in human airway smooth muscle.
Academic Article Cyclooxygenase-2 and microRNA-155 expression are elevated in asthmatic airway smooth muscle cells.
Academic Article High-throughput screening for modulators of cellular contractile force.
Academic Article Chronic Activation of the Renin-Angiotensin System Induces Lung Fibrosis.
Academic Article Future Research Directions in Asthma. An NHLBI Working Group Report.
Academic Article Genome-Wide Methylation Study Identifies an IL-13-induced Epigenetic Signature in Asthmatic Airways.
Academic Article Corticosteroid therapy and airflow obstruction influence the bronchial microbiome, which is distinct from that of bronchoalveolar lavage in asthmatic airways.
Academic Article An inflammation-independent contraction mechanophenotype of airway smooth muscle in asthma.
Academic Article DNA methylation in lung cells is associated with asthma endotypes and genetic risk.
Academic Article Elevated levels of soluble humanleukocyte antigen-G in the airways are a marker for a low-inflammatory endotype of asthma.
Grant Mendelian Disease - Asthma Comorbidity to Find Subgroup-Specific Asthma Genes
Academic Article Associations between environmental quality and adult asthma prevalence in medical claims data.
Academic Article Hypercapnia increases airway smooth muscle contractility via caspase-7-mediated miR-133a-RhoA signaling.
Academic Article SM22 is required for the maintenance of actin-rich structures generated during bacterial infections.
Academic Article Preexisting Type 2 Immune Activation Protects against the Development of Sepsis.
Grant Dissecting the Genetic Architecture of Airway Hyperresponsiveness
Grant MyChoice
Grant Illinois Precision Medicine Consortium (IPMC)
Academic Article Loss of bronchoprotection with ICS plus LABA treatment, ß-receptor dynamics, and the effect of alendronate.
Academic Article Evidence for an IL-6-high asthma phenotype in asthmatic patients of African ancestry.
Academic Article Embedding research recruitment in a community resource e-prescribing system: lessons from an implementation study on Chicago's South Side.
Academic Article Associations between fungal and bacterial microbiota of airways and asthma endotypes.
Academic Article Reply.
Academic Article Step-Up Therapy in Black Children and Adults with Poorly Controlled Asthma.
Academic Article Tissue traction microscopy to quantify muscle contraction within precision-cut lung slices.
Academic Article Role of Isocitrate Dehydrogenase 2 on DNA Hydroxymethylation in Human Airway Smooth Muscle Cells.
Academic Article Association of Vitamin D Deficiency and Treatment with COVID-19 Incidence.
Academic Article Cytokine-induced molecular responses in airway smooth muscle cells inform genome-wide association studies of asthma.
Academic Article Association of Vitamin D Status and Other Clinical Characteristics With COVID-19 Test Results.
Academic Article Geography, generalisability, and susceptibility in clinical trials.
Academic Article Association of Vitamin D Levels, Race/Ethnicity, and Clinical Characteristics With COVID-19 Test Results.
Academic Article Innovations in MD-only physician-scientist training: experiences from the Burroughs Wellcome Fund physician-scientist institutional award initiative.
Academic Article Pharmacogenetic studies of long-acting beta agonist and inhaled corticosteroid responsiveness in randomised controlled trials of individuals of African descent with asthma.
Academic Article Characterizing Long COVID: Deep Phenotype of a Complex Condition.
Academic Article Clinical and translational science and climate change: Time for action.
Academic Article Discerning asthma endotypes through comorbidity mapping.
Concept Fluticasone
Concept Salmeterol Xinafoate
Concept Celecoxib
Concept Pharmacogenomic Testing
Concept Glycogen Synthase Kinase 3 beta
Concept Betacoronavirus
Concept Anoctamin-1
Concept Microbiota
Concept MEF2 Transcription Factors
Academic Article Anoctamin-1 is induced by TGF-beta and contributes to lung myofibroblast differentiation.
Academic Article Pharmacotherapy and pulmonary fibrosis risk after SARS-CoV-2 infection: a prospective nationwide cohort study in the United States.
Academic Article Pharmacotherapy and pulmonary fibrosis risk after SARS-CoV-2 infection-response to Guangting Zeng and Yuchi Zhou.
Academic Article Anoctamin-1 is induced by TGF-ß and contributes to lung myofibroblast differentiation.
Academic Article Sociome Data Commons: A scalable and sustainable platform for investigating the full social context and determinants of health.
Academic Article The N3C governance ecosystem: A model socio-technical partnership for the future of collaborative analytics at scale.
Academic Article Stress and human health in diabetes: A report from the 19th Chicago Biomedical Consortium symposium.
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