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Solway, Julian
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overview Walter L. Palmer Distinguished Service Professor of Medicine and Pediatrics Dean for Translational Medicine Director, Institute for Translational Medicine I am Dean for Translational Medicine and founding Director of the Institute for Translational Medicine, home of the University of Chicago-Rush University NIH/NCATS CTSA award. I have served the CTSA Consortium as a co-Chair, Steering Committee member, and co-Chair of the Strategic Goal 3 and Collaboration/Engagement Domain Task Force. My research programs primarily address asthma. I have extensive experience studying airway smooth muscle (ASM) function and dysfunction in asthma, having studied smooth muscle specific gene transcription, protein accumulation, and hypertrophy, and signaling mechanisms that regulate these; ASM contraction and its reversal, and the mechanisms that regulate these; and ASM mediated-airway narrowing, airway constrictor responsiveness, and lung function in both animal models and humans. Additional studies address asthma genetics and therapeutics in mechanistic and therapeutic clinical studies and preclinical development of novel asthma treatments. Recently, I have focused on the inhibition of pulmonary fibrosis and on the inhibition of breast cancer metastasis using novel small molecules discovered in our asthma studies. I directed the University of Chicago's NHLBI-sponsored T32 Research Training Program in Respiratory Biology for 25 years, led or co-led two NHLBI Multidisciplinary K12 Training Programs, co-led an NIH Broadening Experiences in Scientific Training (BEST) award, and currently lead a Burroughs Wellcome Fund Physician Scientist Institutional Award. My ORCID is 0000-0002-0898-8530. My Scopus ID is 7006796752. My NIH COMMONS name is jsolway. BS 1974 Massachusetts Institute of Technology (Electrical Engineering) MD cum laude 1978 Harvard University (Medicine) Residency 1981 Brigham and Women's Hospital (Internal Medicine) Fellowship 1983 Harvard Medical School (Pulmonary Medicine)
One or more keywords matched the following items that are connected to Solway, Julian
Item TypeName
Concept Muscle, Smooth
Concept Papillary Muscles
Concept Muscle, Smooth, Vascular
Concept Muscle Tonus
Concept Muscle Proteins
Concept Smooth Muscle Myosins
Concept Muscle Contraction
Concept Muscle, Skeletal
Concept Muscle Cells
Concept Myocytes, Smooth Muscle
Academic Article Developmental pattern of expression and genomic organization of the calponin-h1 gene. A contractile smooth muscle cell marker.
Academic Article Differential tachykinin receptor subtype activation in capsaicin and KCl contractions of guinea pig trachealis.
Academic Article Activation of tracheal smooth muscle responsiveness by fMLP-treated HL-60 cells and neutrophils.
Academic Article Perhaps airway smooth muscle dysfunction contributes to asthmatic bronchial hyperresponsiveness after all.
Academic Article Hyperoxia-induced airway remodeling in immature rats. Correlation with airway responsiveness.
Academic Article Bronchoalveolar lavage fluid from asthmatic subjects is mitogenic for human airway smooth muscle.
Academic Article Expression and cytogenetic localization of the human SM22 gene (TAGLN).
Academic Article Transcriptional regulation of smooth muscle contractile apparatus expression.
Academic Article Mutagenesis analysis of human SM22: characterization of actin binding.
Academic Article Hyperoxia-induced airway hyperresponsiveness and remodeling in immature rats.
Academic Article What makes the airways contract abnormally? Is it inflammation?
Academic Article Physiological control of smooth muscle-specific gene expression through regulated nuclear translocation of serum response factor.
Academic Article Divergent differentiation paths in airway smooth muscle culture: induction of functionally contractile myocytes.
Academic Article Fas cross-linking induces apoptosis in human airway smooth muscle cells.
Academic Article Selective restoration of calcium coupling to muscarinic M(3) receptors in contractile cultured airway myocytes.
Academic Article Molecular mechanisms of phenotypic plasticity in smooth muscle cells.
Academic Article Actin dynamics: a potential integrator of smooth muscle (Dys-)function and contractile apparatus gene expression in asthma. Parker B. Francis lecture.
Academic Article Functional significance of protein kinase A activation by endothelin-1 and ATP: negative regulation of SRF-dependent gene expression by PKA.
Academic Article Serum response factor function and dysfunction in smooth muscle.
Academic Article Do inflammatory mediators influence the contribution of airway smooth muscle contraction to airway hyperresponsiveness in asthma?
Academic Article Human bronchial smooth muscle cell lines show a hypertrophic phenotype typical of severe asthma.
Academic Article Methodologic advancements in the study of airway smooth muscle.
Academic Article Can we differentiate between airway and vascular smooth muscle?
Academic Article What evidence implicates airway smooth muscle in the cause of BHR?
Academic Article The RhoA/Rho kinase pathway regulates nuclear localization of serum response factor.
Academic Article Time course of bronchoconstriction induced by dry gas hyperpnea in guinea pigs.
Academic Article SRF function in vascular smooth muscle: when less is more?
Academic Article Tidal breathing pattern differentially antagonizes bronchoconstriction in C57BL/6J vs. A/J mice.
Academic Article Expression cloning identifies transgelin (SM22) as a novel repressor of 92-kDa type IV collagenase (MMP-9) expression.
Academic Article Inhibition of transforming growth factor beta-enhanced serum response factor-dependent transcription by SMAD7.
Academic Article Latrunculin B increases force fluctuation-induced relengthening of ACh-contracted, isotonically shortened canine tracheal smooth muscle.
Academic Article Airway smooth muscle as a target for asthma therapy.
Academic Article Airway smooth muscle dynamics: a common pathway of airway obstruction in asthma.
Academic Article On the terminology for describing the length-force relationship and its changes in airway smooth muscle.
Academic Article Airway smooth muscle in asthma.
Academic Article Myosin, transgelin, and myosin light chain kinase: expression and function in asthma.
Academic Article Disrupting actin-myosin-actin connectivity in airway smooth muscle as a treatment for asthma?
Academic Article p70 Ribosomal S6 kinase is required for airway smooth muscle cell size enlargement but not increased contractile protein expression.
Academic Article MEK modulates force-fluctuation-induced relengthening of canine tracheal smooth muscle.
Academic Article Epithelium-dependent contraction of airway smooth muscle caused by eosinophil MBP.
Academic Article Differential induction of CD38 expression by TNF-{alpha} in asthmatic airway smooth muscle cells.
Academic Article Force fluctuation-induced relengthening of acetylcholine-contracted airway smooth muscle.
Academic Article Kv7 potassium channels in airway smooth muscle cells: signal transduction intermediates and pharmacological targets for bronchodilator therapy.
Academic Article miR-140-3p regulation of TNF-a-induced CD38 expression in human airway smooth muscle cells.
Academic Article Steroids augment relengthening of contracted airway smooth muscle: potential additional mechanism of benefit in asthma.
Academic Article Bronchoalveolar lavage fluid from immature rats with hyperoxia-induced airway remodeling is mitogenic for airway smooth muscle.
Academic Article Immune sensitization augments epithelium-dependent spontaneous tone in guinea pig trachealis.
Academic Article Hyperoxia increases airway cell S-phase traversal in immature rats in vivo.
Academic Article Exposure of immature rats to hyperoxia increases tracheal smooth muscle stress generation in vitro.
Academic Article Akt activation induces hypertrophy without contractile phenotypic maturation in airway smooth muscle.
Academic Article Histamine antagonizes serotonin and growth factor-induced mitogen-activated protein kinase activation in bovine tracheal smooth muscle cells.
Academic Article Hydrogen peroxide stimulates mitogen-activated protein kinase in bovine tracheal myocytes: implications for human airway disease.
Academic Article Recovery of airway structure and function after hyperoxic exposure in immature rats.
Academic Article Structure and expression of a smooth muscle cell-specific gene, SM22 alpha.
Academic Article Structural and functional abnormalities of the airways of hyperoxia-exposed immature rats.
Academic Article Alternative promoter and GATA5 transcripts in mouse.
Academic Article Distribution of airway contractile responses within the major diameter bronchi during exogenous bronchoconstriction.
Academic Article Phophatidylinositol-3 kinase/mammalian target of rapamycin/p70S6K regulates contractile protein accumulation in airway myocyte differentiation.
Academic Article Nuclear import of serum response factor in airway smooth muscle.
Academic Article Role of MAP kinase activation in bovine tracheal smooth muscle mitogenesis.
Academic Article Effect of airway inflammation on smooth muscle shortening and contractility in guinea pig trachealis.
Academic Article Mechanical and structural plasticity.
Academic Article Airway smooth muscle in the pathophysiology and treatment of asthma.
Academic Article Gata5 deficiency causes airway constrictor hyperresponsiveness in mice.
Academic Article Airway smooth muscle: a potential target for asthma therapy.
Academic Article Airway contractility in the precision-cut lung slice after cryopreservation.
Academic Article MicroRNA-146a and microRNA-146b expression and anti-inflammatory function in human airway smooth muscle.
Academic Article Cyclooxygenase-2 and microRNA-155 expression are elevated in asthmatic airway smooth muscle cells.
Academic Article High-throughput screening for modulators of cellular contractile force.
Academic Article An inflammation-independent contraction mechanophenotype of airway smooth muscle in asthma.
Academic Article Hypercapnia increases airway smooth muscle contractility via caspase-7-mediated miR-133a-RhoA signaling.
Academic Article SM22 is required for the maintenance of actin-rich structures generated during bacterial infections.
Grant Dissecting the Genetic Architecture of Airway Hyperresponsiveness
Academic Article Tissue traction microscopy to quantify muscle contraction within precision-cut lung slices.
Academic Article Role of Isocitrate Dehydrogenase 2 on DNA Hydroxymethylation in Human Airway Smooth Muscle Cells.
Academic Article Cytokine-induced molecular responses in airway smooth muscle cells inform genome-wide association studies of asthma.
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  • Muscles