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One or more keywords matched the following properties of Randall, Glenn C.
keywords hepatitis C virus
overview Our laboratory investigates the roles of virus-host interactions in replication and pathogenesis. We study RNA viruses, including hepatitis C virus, dengue virus, Zika virus, and noroviruses. These are medically important viruses, causing cirrhosis/liver cancer, hemorrhagic fever, birth defects, and severe GI disease, respectively. We have identified ~100 host cofactors of viral replication. We now study the importance of these cellular genes in diverse steps of the viral life cycle, including entry, the regulation of viral protein translation and RNA replication, modulation of cellular lipid metabolism, the establishment of viral replication complexes, the secretion of infectious virus, and control of infection by the innate immune system.
One or more keywords matched the following items that are connected to Randall, Glenn C.
Item TypeName
Concept Hepacivirus
Academic Article Clearance of replicating hepatitis C virus replicon RNAs in cell culture by small interfering RNAs.
Academic Article CD81 is required for hepatitis C virus glycoprotein-mediated viral infection.
Academic Article Interfering with hepatitis C virus RNA replication.
Academic Article RNA interference and single particle tracking analysis of hepatitis C virus endocytosis.
Academic Article Roles for endocytic trafficking and phosphatidylinositol 4-kinase III alpha in hepatitis C virus replication.
Academic Article Molecular determinants and dynamics of hepatitis C virus secretion.
Academic Article Possibilities for RNA interference in developing hepatitis C virus therapeutics.
Academic Article Hepatitis C virus stimulates the phosphatidylinositol 4-kinase III alpha-dependent phosphatidylinositol 4-phosphate production that is essential for its replication.
Academic Article Cellular cofactors affecting hepatitis C virus infection and replication.
Academic Article Potential roles for cellular cofactors in hepatitis C virus replication complex formation.
Academic Article Hepatitis C virus-host interactions, replication, and viral assembly.
Academic Article A summary of the 18th International Symposium on Hepatitis C Virus and Related Viruses.
Academic Article EWSR1 binds the hepatitis C virus cis-acting replication element and is required for efficient viral replication.
Academic Article Silencing of USP18 potentiates the antiviral activity of interferon against hepatitis C virus infection.
Academic Article Daclatasvir inhibits hepatitis C virus NS5A motility and hyper-accumulation of phosphoinositides.
Academic Article Identification and comparative analysis of hepatitis C virus-host cell protein interactions.
Academic Article Spatiotemporal analysis of hepatitis C virus infection.
Academic Article Hepatitis C virus replication compartment formation: mechanism and drug target.
Academic Article Flunarizine prevents hepatitis C virus membrane fusion in a genotype-dependent manner by targeting the potential fusion peptide within E1.
Academic Article Anticancer kinase inhibitors impair intracellular viral trafficking and exert broad-spectrum antiviral effects.
Academic Article Single Particle Imaging of Polarized Hepatoma Organoids upon Hepatitis C Virus Infection Reveals an Ordered and Sequential Entry Process.
Academic Article RNA triphosphatase DUSP11 enables exonuclease XRN-mediated restriction of hepatitis C virus.
Academic Article Interactions between the Hepatitis C Virus Nonstructural 2 Protein and Host Adaptor Proteins 1 and 4 Orchestrate Virus Release.
Academic Article Live Cell Imaging of Hepatitis C Virus Trafficking in Hepatocytes.
Academic Article Liver-expressed Cd302 and Cr1l limit hepatitis C virus cross-species transmission to mice.
Academic Article Three-Dimensional Cell Culture Systems for Studying Hepatitis C Virus.
Academic Article Transcriptional Inhibition of MicroRNA miR-122 by Small Molecules Reduces Hepatitis C Virus Replication in Liver Cells.
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  • Hepacivirus