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One or more keywords matched the following properties of Randall, Glenn C.
PropertyValue
keywords hepatitis C virus
keywords dengue virus
keywords virus-host interactions
overview Our laboratory investigates the roles of virus-host interactions in replication and pathogenesis. We study RNA viruses, including hepatitis C virus, dengue virus, Zika virus, and noroviruses. These are medically important viruses, causing cirrhosis/liver cancer, hemorrhagic fever, birth defects, and severe GI disease, respectively. We have identified ~100 host cofactors of viral replication. We now study the importance of these cellular genes in diverse steps of the viral life cycle, including entry, the regulation of viral protein translation and RNA replication, modulation of cellular lipid metabolism, the establishment of viral replication complexes, the secretion of infectious virus, and control of infection by the innate immune system.
One or more keywords matched the following items that are connected to Randall, Glenn C.
Item TypeName
Concept Dengue Virus
Concept DNA Virus Infections
Concept DNA Viruses
Concept Hepatitis Viruses
Concept RNA Viruses
Concept Virus Replication
Concept Virus Assembly
Concept Virus Latency
Concept Virus Physiological Phenomena
Concept Virus Attachment
Concept Virus Inactivation
Concept Viruses
Concept Virus Internalization
Concept Virus Release
Concept Receptors, Virus
Concept RNA Virus Infections
Concept Virus Diseases
Academic Article Phenotypic properties of herpes simplex virus 1 containing a derepressed open reading frame P gene.
Academic Article The product of ORF O located within the domain of herpes simplex virus 1 genome transcribed during latent infection binds to and inhibits in vitro binding of infected cell protein 4 to its cognate DNA site.
Academic Article Herpes simplex virus 1 open reading frames O and P are not necessary for establishment of latent infection in mice.
Academic Article Clearance of replicating hepatitis C virus replicon RNAs in cell culture by small interfering RNAs.
Academic Article CD81 is required for hepatitis C virus glycoprotein-mediated viral infection.
Academic Article Interfering with hepatitis C virus RNA replication.
Academic Article RNA interference and single particle tracking analysis of hepatitis C virus endocytosis.
Academic Article Roles for endocytic trafficking and phosphatidylinositol 4-kinase III alpha in hepatitis C virus replication.
Academic Article Dengue virus-induced autophagy regulates lipid metabolism.
Academic Article Molecular determinants and dynamics of hepatitis C virus secretion.
Academic Article Manipulation or capitulation: virus interactions with autophagy.
Academic Article Multifaceted roles for lipids in viral infection.
Academic Article Possibilities for RNA interference in developing hepatitis C virus therapeutics.
Academic Article A physical interaction network of dengue virus and human proteins.
Academic Article Dengue virus and autophagy.
Academic Article Hepatitis C virus stimulates the phosphatidylinositol 4-kinase III alpha-dependent phosphatidylinositol 4-phosphate production that is essential for its replication.
Academic Article Lipids at the interface of virus-host interactions.
Academic Article Cellular cofactors affecting hepatitis C virus infection and replication.
Academic Article Potential roles for cellular cofactors in hepatitis C virus replication complex formation.
Academic Article Transcription of the derepressed open reading frame P of herpes simplex virus 1 precludes the expression of the antisense gamma(1)34.5 gene and may account for the attenuation of the mutant virus.
Academic Article Dengue virus nonstructural protein 3 redistributes fatty acid synthase to sites of viral replication and increases cellular fatty acid synthesis.
Academic Article Hepatitis C virus-host interactions, replication, and viral assembly.
Academic Article A summary of the 18th International Symposium on Hepatitis C Virus and Related Viruses.
Academic Article EWSR1 binds the hepatitis C virus cis-acting replication element and is required for efficient viral replication.
Academic Article Silencing of USP18 potentiates the antiviral activity of interferon against hepatitis C virus infection.
Academic Article Daclatasvir inhibits hepatitis C virus NS5A motility and hyper-accumulation of phosphoinositides.
Academic Article Identification and comparative analysis of hepatitis C virus-host cell protein interactions.
Academic Article Spatiotemporal analysis of hepatitis C virus infection.
Academic Article Hepatitis C virus replication compartment formation: mechanism and drug target.
Academic Article Lipids in innate antiviral defense.
Academic Article Flunarizine prevents hepatitis C virus membrane fusion in a genotype-dependent manner by targeting the potential fusion peptide within E1.
Academic Article Positive-strand RNA viruses stimulate host phosphatidylcholine synthesis at viral replication sites.
Academic Article (+) RNA virus replication compartments: a safe home for (most) viral replication.
Academic Article Flavivirus modulation of cellular metabolism.
Academic Article Anticancer kinase inhibitors impair intracellular viral trafficking and exert broad-spectrum antiviral effects.
Academic Article Dengue Virus Activates the AMP Kinase-mTOR Axis To Stimulate a Proviral Lipophagy.
Academic Article Single Particle Imaging of Polarized Hepatoma Organoids upon Hepatitis C Virus Infection Reveals an Ordered and Sequential Entry Process.
Academic Article RNA triphosphatase DUSP11 enables exonuclease XRN-mediated restriction of hepatitis C virus.
Academic Article Lipid Droplet Metabolism during Dengue Virus Infection.
Academic Article Interactions between the Hepatitis C Virus Nonstructural 2 Protein and Host Adaptor Proteins 1 and 4 Orchestrate Virus Release.
Academic Article Live Cell Imaging of Hepatitis C Virus Trafficking in Hepatocytes.
Academic Article Host Lipids in Positive-Strand RNA Virus Genome Replication.
Academic Article Virus Impact on Lipids and Membranes.
Academic Article CD300LF Polymorphisms of Inbred Mouse Strains Confer Resistance to Murine Norovirus Infection in a Cell Type-Dependent Manner.
Academic Article Liver-expressed Cd302 and Cr1l limit hepatitis C virus cross-species transmission to mice.
Academic Article Structure of papain-like protease from SARS-CoV-2 and its complexes with non-covalent inhibitors.
Academic Article Three-Dimensional Cell Culture Systems for Studying Hepatitis C Virus.
Academic Article Masitinib is a broad coronavirus 3CL inhibitor that blocks replication of SARS-CoV-2.
Academic Article A Multifunctional Neutralizing Antibody-Conjugated Nanoparticle Inhibits and Inactivates SARS-CoV-2.
Academic Article Cannabidiol inhibits SARS-CoV-2 replication through induction of the host ER stress and innate immune responses.
Academic Article The cargo adapter protein CLINT1 is phosphorylated by the Numb-associated kinase BIKE and mediates dengue virus infection.
Academic Article Transcriptional Inhibition of MicroRNA miR-122 by Small Molecules Reduces Hepatitis C Virus Replication in Liver Cells.
Academic Article CAPRIN1 Is Required for Control of Viral Replication Complexes by Interferon Gamma.
Academic Article Roles of epidermal growth factor receptor, claudin-1 and occludin in multi-step entry of hepatitis C virus into polarized hepatoma spheroids.
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  • Viruses