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One or more keywords matched the following properties of Shuman, Howard A.
keywords Legionella pneumophila
overview Our group is interested in how intracellular bacterial pathogens interact with and commandeer host cell functions during infection. We have studied the intracellular human pathogen, Legionella pneumophila for more than 30 years. This gram-negative species causes an acute febrile pneumonia called Legionnaires’ disease. People become infected with Legionella when they inhale contaminated aerosols. This can happen when cooling and ventilation systems, fountains, or whirlpools become contaminated. In these environments, Legionella replicates in single-celled amoebae. In human lungs these bacteria can infect and replicate in alveolar macrophages. In order to understand how Legionella is able to survive and grow inside amoebae and macrophages, we use genetic and genomic approaches to ask which functions in the bacteria and which ones in the host are important for infection. We found that Legionella has a “Type IV Secretion System” called the Icm/Dot System that translocates protein “effectors” to the host cell and that these effectors dramatically alter organelle trafficking in host cells as is shown in the accompanying diagram. The Legionella – containing vacuole, (LCV) is where the bacteria grow within cells in a nutrient-rich, protected niche. Current Position: 2010 - Professor of Microbiology, University of Chicago Education: 1970-1974 University of Massachusetts, B.S. (Microbiology, honors) 1975-1980 Harvard University, Ph.D. (Biological Chemistry) 1980-1982 Postdoctoral Fellow, Department of Biochemistry & Molecular Biology, Harvard University Employment / Experience: 1974-1975 Research Assistant, Institut Pasteur, Paris, France 1982-1989 Assistant Professor, Department of Microbiology, Columbia University 1989-1995 Associate Professor, Department of Microbiology, Columbia University 1995- 2010 Professor, Department of Microbiology, Columbia University 2005- 2008 Director of Graduate Studies, Department of Microbiology, Columbia University 2008 Interim Chair, Department of Microbiology, Columbia University 2010 Professor Emeritus, Department of Microbiology & Immunology, Columbia University 2010-2015 Director, Howard Taylor Ricketts Regional Biocontainment Laboratory Professional Service: 1986- 1997 Editorial Board, Journal of Bacteriology 1989- 1992 Editorial Board, Infection and Immunity 1994- 1999 Editorial Board, The Journal of Biological Chemistry 1998 Co-Chair, Gordon Research Conference: "Bacterial Cell Surfaces" 2007 Guest Editor, Proceedings of the National Academy of Sciences 2009 Editorial Board, Protist 2009 - 2010 Steering Committee, Northeast Biodefense Center 2009 - 2019 Editorial Board, mBio
One or more keywords matched the following items that are connected to Shuman, Howard A.
Item TypeName
Academic Article Legionella pneumophila invasion of mononuclear phagocytes.
Academic Article Identification of a Legionella pneumophila locus required for intracellular multiplication in human macrophages.
Academic Article How is the intracellular fate of the Legionella pneumophila phagosome determined?
Academic Article Intracellular multiplication of Legionella pneumophila: human pathogen or accidental tourist?
Academic Article Characterization of a new region required for macrophage killing by Legionella pneumophila.
Academic Article Genetics of Legionella pneumophila virulence.
Academic Article Relationships between a new type IV secretion system and the icm/dot virulence system of Legionella pneumophila.
Academic Article Legionella pneumophila utilizes the same genes to multiply within Acanthamoeba castellanii and human macrophages.
Academic Article Legionella pneumophila contains a type II general secretion pathway required for growth in amoebae as well as for secretion of the Msp protease.
Academic Article Host cell killing and bacterial conjugation require overlapping sets of genes within a 22-kb region of the Legionella pneumophila genome.
Academic Article Possible origin of the Legionella pneumophila virulence genes and their relation to Coxiella burnetii.
Academic Article Intracellular multiplication and human macrophage killing by Legionella pneumophila are inhibited by conjugal components of IncQ plasmid RSF1010.
Academic Article Early events in phagosome establishment are required for intracellular survival of Legionella pneumophila.
Academic Article The Legionella pneumophila icmGCDJBF genes are required for killing of human macrophages.
Academic Article Icm/dot-dependent upregulation of phagocytosis by Legionella pneumophila.
Academic Article Phagocytosis of wild-type Legionella pneumophila occurs through a wortmannin-insensitive pathway.
Academic Article Virulence conversion of Legionella pneumophila by conjugal transfer of chromosomal DNA.
Academic Article Comparative sequence analysis of the icm/dot genes in Legionella.
Academic Article Macroautophagy is dispensable for intracellular replication of Legionella pneumophila in Dictyostelium discoideum.
Academic Article Legionella effectors that promote nonlytic release from protozoa.
Academic Article The amoebae plate test implicates a paralogue of lpxB in the interaction of Legionella pneumophila with Acanthamoeba castellanii.
Academic Article Pathogen effector protein screening in yeast identifies Legionella factors that interfere with membrane trafficking.
Academic Article An immunoprotective molecule, the major secretory protein of Legionella pneumophila, is not a virulence factor in a guinea pig model of Legionnaires' disease.
Academic Article The genomic sequence of the accidental pathogen Legionella pneumophila.
Academic Article Legionella eukaryotic-like type IV substrates interfere with organelle trafficking.
Academic Article Interferons direct an effective innate response to Legionella pneumophila infection.
Academic Article The Legionella pneumophila major secretory protein, a protease, is not required for intracellular growth or cell killing.
Academic Article ArgR-regulated genes are derepressed in the Legionella-containing vacuole.
Academic Article Cyclic diguanylate signaling proteins control intracellular growth of Legionella pneumophila.
Academic Article Host cell-dependent secretion and translocation of the LepA and LepB effectors of Legionella pneumophila.
Academic Article Loss of RNase R induces competence development in Legionella pneumophila.
Academic Article Antibiotics and UV radiation induce competence for natural transformation in Legionella pneumophila.
Academic Article Isolation of a Legionella pneumophila restriction mutant with increased ability to act as a recipient in heterospecific matings.
Academic Article The overlapping host responses to bacterial cyclic dinucleotides.
Academic Article The Legionella pneumophila icm locus: a set of genes required for intracellular multiplication in human macrophages.
Academic Article Evidence for acquisition of Legionella type IV secretion substrates via interdomain horizontal gene transfer.
Academic Article Gemfibrozil inhibits Legionella pneumophila and Mycobacterium tuberculosis enoyl coenzyme A reductases and blocks intracellular growth of these bacteria in macrophages.
Academic Article The perplexing functions and surprising origins of Legionella pneumophila type IV secretion effectors.
Academic Article Chemical genetics reveals bacterial and host cell functions critical for type IV effector translocation by Legionella pneumophila.
Academic Article The Legionella pneumophila effector VipA is an actin nucleator that alters host cell organelle trafficking.
Academic Article Isolation and characterization of auxotrophic mutants of Legionella pneumophila that fail to multiply in human monocytes.
Academic Article Whole-genome sequence of the human pathogen Legionella pneumophila serogroup 12 strain 570-CO-H.
Academic Article Genetics of Legionella pneumophila.
Academic Article Escherichia coli F plasmid transfers to and replicates within Legionella pneumophila: an alternative to using an RP4-based system for gene delivery.
Academic Article The iron superoxide dismutase of Legionella pneumophila is essential for viability.
Academic Article Genetics and molecular pathogenesis of Legionella pneumophila, an intracellular parasite of macrophages.
Academic Article Identification of Legionella pneumophila genes required for growth within and killing of human macrophages.
Academic Article Mutagenesis of Legionella pneumophila using Tn903 dlllacZ: identification of a growth-phase-regulated pigmentation gene.
Academic Article Small Regulatory RNA and Legionella pneumophila.
Academic Article The Legionella pneumophila rpoS gene is required for growth within Acanthamoeba castellanii.
Academic Article SigmaS controls multiple pathways associated with intracellular multiplication of Legionella pneumophila.
Academic Article Legionella pneumophila 6S RNA optimizes intracellular multiplication.
Academic Article Legionella Pneumophila Transcriptome during Intracellular Multiplication in Human Macrophages.
Academic Article Legionella pneumophila transcriptional response following exposure to CuO nanoparticles.
Academic Article In vitro derivation of macrophage from guinea pig bone marrow with human M-CSF.
Academic Article Computational modeling and experimental validation of the Legionella and Coxiella virulence-related type-IVB secretion signal.
Academic Article A bacterial protein promotes the recognition of the Legionella pneumophila vacuole by autophagy.
Academic Article Diverse protist grazers select for virulence-related traits in Legionella.
Academic Article Host-directed antimicrobial drugs with broad-spectrum efficacy against intracellular bacterial pathogens.
Academic Article Analysis of the transcriptome of Legionella pneumophila hfq mutant reveals a new mobile genetic element.
Academic Article Direct targeting of membrane fusion by SNARE mimicry: Convergent evolution of Legionella effectors.
Academic Article Seeing red; the development of pON.mCherry, a broad-host range constitutive expression plasmid for Gram-negative bacteria.
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  • Legionella pneumophila