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overview Our group is interested in how intracellular bacterial pathogens interact with and commandeer host cell functions during infection. We have studied the intracellular human pathogen, Legionella pneumophila for more than 30 years. This gram-negative species causes an acute febrile pneumonia called Legionnaires’ disease. People become infected with Legionella when they inhale contaminated aerosols. This can happen when cooling and ventilation systems, fountains, or whirlpools become contaminated. In these environments, Legionella replicates in single-celled amoebae. In human lungs these bacteria can infect and replicate in alveolar macrophages. In order to understand how Legionella is able to survive and grow inside amoebae and macrophages, we use genetic and genomic approaches to ask which functions in the bacteria and which ones in the host are important for infection. We found that Legionella has a “Type IV Secretion System” called the Icm/Dot System that translocates protein “effectors” to the host cell and that these effectors dramatically alter organelle trafficking in host cells as is shown in the accompanying diagram. The Legionella – containing vacuole, (LCV) is where the bacteria grow within cells in a nutrient-rich, protected niche. Current Position: 2010 - Professor of Microbiology, University of Chicago Education: 1970-1974 University of Massachusetts, B.S. (Microbiology, honors) 1975-1980 Harvard University, Ph.D. (Biological Chemistry) 1980-1982 Postdoctoral Fellow, Department of Biochemistry & Molecular Biology, Harvard University Employment / Experience: 1974-1975 Research Assistant, Institut Pasteur, Paris, France 1982-1989 Assistant Professor, Department of Microbiology, Columbia University 1989-1995 Associate Professor, Department of Microbiology, Columbia University 1995- 2010 Professor, Department of Microbiology, Columbia University 2005- 2008 Director of Graduate Studies, Department of Microbiology, Columbia University 2008 Interim Chair, Department of Microbiology, Columbia University 2010 Professor Emeritus, Department of Microbiology & Immunology, Columbia University 2010-2015 Director, Howard Taylor Ricketts Regional Biocontainment Laboratory Professional Service: 1986- 1997 Editorial Board, Journal of Bacteriology 1989- 1992 Editorial Board, Infection and Immunity 1994- 1999 Editorial Board, The Journal of Biological Chemistry 1998 Co-Chair, Gordon Research Conference: "Bacterial Cell Surfaces" 2007 Guest Editor, Proceedings of the National Academy of Sciences 2009 Editorial Board, Protist 2009 - 2010 Steering Committee, Northeast Biodefense Center 2009 - 2019 Editorial Board, mBio
One or more keywords matched the following items that are connected to Shuman, Howard A.
Item TypeName
Concept Legionnaires' Disease
Academic Article An immunoprotective molecule, the major secretory protein of Legionella pneumophila, is not a virulence factor in a guinea pig model of Legionnaires' disease.
Academic Article Legionella eukaryotic-like type IV substrates interfere with organelle trafficking.
Academic Article Interferons direct an effective innate response to Legionella pneumophila infection.
Academic Article ArgR-regulated genes are derepressed in the Legionella-containing vacuole.
Academic Article Cyclic diguanylate signaling proteins control intracellular growth of Legionella pneumophila.
Academic Article Chemical genetics reveals bacterial and host cell functions critical for type IV effector translocation by Legionella pneumophila.
Academic Article Isolation and characterization of auxotrophic mutants of Legionella pneumophila that fail to multiply in human monocytes.
Academic Article Whole-genome sequence of the human pathogen Legionella pneumophila serogroup 12 strain 570-CO-H.
Academic Article Genetics and molecular pathogenesis of Legionella pneumophila, an intracellular parasite of macrophages.
Academic Article Identification of Legionella pneumophila genes required for growth within and killing of human macrophages.
Academic Article The HL-60 model for the interaction of human macrophages with the Legionnaires' disease bacterium.
Academic Article Transposition of bacteriophage Mu in the Legionnaires disease bacterium.
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