Item Type | Name |
Concept
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DNA-Binding Proteins
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Concept
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DNA Repair
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Concept
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DNA Mutational Analysis
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Concept
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DNA, Neoplasm
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Concept
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DNA, Recombinant
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Concept
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DNA
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Concept
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DNA-Directed DNA Polymerase
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Concept
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DNA, Superhelical
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Concept
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DNA Polymerase III
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Concept
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DNA Replication
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Concept
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RNA-Directed DNA Polymerase
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Concept
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DNA Probes
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Concept
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Sequence Analysis, DNA
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Concept
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DNA, Complementary
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Concept
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DNA-Activated Protein Kinase
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Concept
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DNA Footprinting
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Concept
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DNA Glycosylases
|
Concept
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DNA Methylation
|
Concept
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DNA Mismatch Repair
|
Concept
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Uracil-DNA Glycosidase
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Concept
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DNA Restriction Enzymes
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Concept
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DNA, Single-Stranded
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Concept
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DNA Primers
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Academic Article
|
PU.1 is a component of a multiprotein complex which binds an essential site in the murine immunoglobulin lambda 2-4 enhancer.
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Academic Article
|
Identification and characterization of the murine Rag1 promoter.
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Academic Article
|
B lymphocytes of xeroderma pigmentosum or Cockayne syndrome patients with inherited defects in nucleotide excision repair are fully capable of somatic hypermutation of immunoglobulin genes.
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Academic Article
|
The inactivation of the XP-C gene does not affect somatic hypermutation or class switch recombination of immunoglobulin genes.
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Academic Article
|
Rearrangement and expression of immunoglobulin genes in transgenic mice.
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Academic Article
|
Mef2 proteins, required for muscle differentiation, bind an essential site in the Ig lambda enhancer.
|
Academic Article
|
A linkage map of distal mouse chromosome 4 in the vicinity of Ssm1, a strain-specific modifier of methylation.
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Academic Article
|
Cis-acting sequences that affect somatic hypermutation of Ig genes.
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Academic Article
|
Somatic hypermutation of immunoglobulin and non-immunoglobulin genes.
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Academic Article
|
Mutation of BCL-6 gene in normal B cells by the process of somatic hypermutation of Ig genes.
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Academic Article
|
A hypermutable insert in an immunoglobulin transgene contains hotspots of somatic mutation and sequences predicting highly stable structures in the RNA transcript.
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Academic Article
|
Hypomethylation is necessary but not sufficient for V(D)J recombination within a transgenic substrate.
|
Academic Article
|
The TATA binding protein, c-Myc and survivin genes are not somatically hypermutated, while Ig and BCL6 genes are hypermutated in human memory B cells.
|
Academic Article
|
The role of DNA repair in somatic hypermutation of immunoglobulin genes.
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Academic Article
|
A cis-acting element that directs the activity of the murine methylation modifier locus Ssm1.
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Academic Article
|
Signal joint formation is inhibited in murine scid preB cells and fibroblasts in substrates with homopolymeric coding ends.
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Academic Article
|
Effects of sequence and structure on the hypermutability of immunoglobulin genes.
|
Academic Article
|
Two conserved essential motifs of the murine immunoglobulin lambda enhancers bind B-cell-specific factors.
|
Academic Article
|
A novel cytidine deaminase AIDs in the delivery of error-prone polymerases to immunoglobulin genes.
|
Academic Article
|
The E box motif CAGGTG enhances somatic hypermutation without enhancing transcription.
|
Academic Article
|
Mutation pattern of immunoglobulin transgenes is compatible with a model of somatic hypermutation in which targeting of the mutator is linked to the direction of DNA replication.
|
Academic Article
|
Ig gene somatic hypermutation in mice defective for DNA polymerase delta proofreading.
|
Academic Article
|
Activation-induced cytidine deaminase (AID) can target both DNA strands when the DNA is supercoiled.
|
Academic Article
|
Somatic hypermutation and class switch recombination in Msh6(-/-)Ung(-/-) double-knockout mice.
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Academic Article
|
The contested role of uracil DNA glycosylase in immunoglobulin gene diversification.
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Academic Article
|
AID in somatic hypermutation and class switch recombination.
|
Academic Article
|
Targeting of the activation-induced cytosine deaminase is strongly influenced by the sequence and structure of the targeted DNA.
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Academic Article
|
A novel enhancer in the immunoglobulin lambda locus is duplicated and functionally independent of NF kappa B.
|
Academic Article
|
Alkyladenine DNA glycosylase (Aag) in somatic hypermutation and class switch recombination.
|
Academic Article
|
Differential splicing of thymosin beta 4 mRNA.
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Academic Article
|
Transgenic mice with mu and kappa genes encoding antiphosphorylcholine antibodies.
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Academic Article
|
The activation-induced cytidine deaminase (AID) efficiently targets DNA in nucleosomes but only during transcription.
|
Academic Article
|
A strain-specific modifier on mouse chromosome 4 controls the methylation of independent transgene loci.
|
Academic Article
|
Somatic hypermutation: processivity of the cytosine deaminase AID and error-free repair of the resulting uracils.
|
Academic Article
|
Brca1 in immunoglobulin gene conversion and somatic hypermutation.
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Academic Article
|
Somatic hypermutation of an immunoglobulin transgene in kappa transgenic mice.
|
Academic Article
|
Analysis of somatic mutations in kappa transgenes.
|
Academic Article
|
Quantitation of immunoglobulin genes by nucleic acid hybridization with RNA from myeloma and spleen microsomes.
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Academic Article
|
Comparison of different rearranged immunoglobulin kappa genes of a myeloma by electronmicroscopy and restriction mapping of cloned DNA: implications for "allelic exclusion".
|
Academic Article
|
Rearrangement of immunoglobulin genes.
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Academic Article
|
Strain-specific transgene methylation occurs early in mouse development and can be recapitulated in embryonic stem cells.
|
Academic Article
|
Analysis of immunoglobulin genes: DNA/RNA hybridization with immunoglobulin kappa-chain mRNA and isolation and translation of hybridized RNA.
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Academic Article
|
Synthesis of specific RNA molecules during immune response in the mouse spleen.
|
Academic Article
|
Immunoglobulin genes in DNA restriction fragments.
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Academic Article
|
Immunoglobulin gene 'remnant' DNA--implications for antibody gene recombination.
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Academic Article
|
Somatic mutation of immunoglobulin light-chain variable-region genes.
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Academic Article
|
Nucleosome stability dramatically impacts the targeting of somatic hypermutation.
|
Academic Article
|
Association of two different repetitive DNA elements near immunoglobulin light chain genes.
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Academic Article
|
Pip, a novel IRF family member, is a lymphoid-specific, PU.1-dependent transcriptional activator.
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Academic Article
|
Immunoglobulin messenger RNAs of T lymphocytes.
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Academic Article
|
Myeloma with multiple rearranged immunoglobulin kappa genes: only one kappa gene codes for kappa chains.
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Academic Article
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Physical linkage of the constant region genes for immunoglobulins lambda I and lambda III.
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Academic Article
|
Methylation patterns of immunoglobulin genes in lymphoid cells: correlation of expression and differentiation with undermethylation.
|
Academic Article
|
Pip, a lymphoid-restricted IRF, contains a regulatory domain that is important for autoinhibition and ternary complex formation with the Ets factor PU.1.
|
Academic Article
|
The bulk chromatin structure of a murine transgene does not vary with its transcriptional or DNA methylation status.
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Academic Article
|
Crossing the SJL lambda locus into kappa-knockout mice reveals a dysfunction of the lambda 1-containing immunoglobulin receptor in B cell differentiation.
|
Academic Article
|
Different mismatch repair deficiencies all have the same effects on somatic hypermutation: intact primary mechanism accompanied by secondary modifications.
|
Academic Article
|
Molecular aspects of somatic hypermutation of immunoglobulin genes.
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Academic Article
|
The 3' Igkappa enhancer contains RNA polymerase II promoters: implications for endogenous and transgenic kappa gene expression.
|
Academic Article
|
DNA polymerases in immunity: profiting from errors.
|
Academic Article
|
Immunoglobulin genes: generating diversity with AID and UNG.
|
Academic Article
|
The transcription factor Spi-B is not required for somatic hypermutation.
|
Academic Article
|
DNA methylation precedes chromatin modifications under the influence of the strain-specific modifier Ssm1.
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Academic Article
|
The very 5' end and the constant region of Ig genes are spared from somatic mutation because AID does not access these regions.
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Academic Article
|
Targeting of AID to immunoglobulin genes.
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Academic Article
|
The pattern of somatic hypermutation of Ig genes is altered when p53 is inactivated.
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Academic Article
|
Physical linkage of mouse lambda genes by pulsed-field gel electrophoresis suggests that the rearrangement process favors proximate target sequences.
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Academic Article
|
Feedback inhibition of immunoglobulin gene rearrangement by membrane mu, but not by secreted mu heavy chains.
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Academic Article
|
Pre-B cells in kappa-transgenic mice.
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Academic Article
|
Immunoglobulin gene rearrangements in hybridoma cells.
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Academic Article
|
Mapping of immunoglobulin variable region genes: relationship to the 'deletion' model of immunoglobulin gene rearrangement.
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Academic Article
|
Immunoglobulin synthesis by T cells: quantitative and qualitative aspects.
|
Academic Article
|
Evidence for multiple immunoglobulin genes.
|
Academic Article
|
Changes in RNA polymerase II progression influence somatic hypermutation of Ig-related genes by AID.
|
Academic Article
|
Turnover of myeloma messenger DNA.
|
Academic Article
|
Identification of Ssm1b, a novel modifier of DNA methylation, and its expression during mouse embryogenesis.
|
Academic Article
|
Ssm1b expression and function in germ cells of adult mice and in early embryos.
|
Grant
|
CONTROL OF IMMUNOGLOBULIN SYNTHESIS
|
Grant
|
CONTROL OF IMMUNOGLOBULIN SYNTHESIS
|
Grant
|
CONTROL OF IMMUNOGLOBULIN SYNTHESIS
|
Grant
|
Mechanism of Immunoglobulin Hypermutation
|
Grant
|
AID in somatic mutation of immunoglobulin genes
|
Grant
|
Immunoglobulin Somatic Mutation
|
Grant
|
Identification of the DNA methylation/chromatin modifier Ssm1
|