| Item Type | Name |
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Concept
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B-Lymphocytes
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Concept
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Gene Rearrangement, B-Lymphocyte
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Concept
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Gene Rearrangement, T-Lymphocyte
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Concept
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B-Lymphocyte Subsets
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Concept
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Gene Rearrangement, B-Lymphocyte, Heavy Chain
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Concept
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Gene Rearrangement, B-Lymphocyte, Light Chain
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Concept
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Lymphocyte Count
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Concept
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Lymphocyte Activation
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Concept
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Lymphocytes
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Concept
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T-Lymphocytes
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Academic Article
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Lymphocyte development.
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Academic Article
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Influence of CpG methylation and target spacing on V(D)J recombination in a transgenic substrate.
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Academic Article
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Somatic hypermutation of immunoglobulin genes is linked to transcription initiation.
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Academic Article
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N region diversity of a transgenic substrate in fetal and adult lymphoid cells.
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Academic Article
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Identification and characterization of the murine Rag1 promoter.
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Academic Article
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Gamma 2b provides only some of the signals normally given via mu in B cell development.
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Academic Article
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B lymphocytes of xeroderma pigmentosum or Cockayne syndrome patients with inherited defects in nucleotide excision repair are fully capable of somatic hypermutation of immunoglobulin genes.
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Academic Article
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The composition of coding joints formed in V(D)J recombination is strongly affected by the nucleotide sequence of the coding ends and their relationship to the recombination signal sequences.
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Academic Article
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Somatic hypermutation of immunoglobulin genes is linked to transcription.
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Academic Article
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Mef2 proteins, required for muscle differentiation, bind an essential site in the Ig lambda enhancer.
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Academic Article
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Somatic hypermutation of immunoglobulin and non-immunoglobulin genes.
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Academic Article
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Mutation of BCL-6 gene in normal B cells by the process of somatic hypermutation of Ig genes.
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Academic Article
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Hypomethylation is necessary but not sufficient for V(D)J recombination within a transgenic substrate.
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Academic Article
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The TATA binding protein, c-Myc and survivin genes are not somatically hypermutated, while Ig and BCL6 genes are hypermutated in human memory B cells.
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Academic Article
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Insertion of phosphoglycerine kinase (PGK)-neo 5' of Jlambda1 dramatically enhances VJlambda1 rearrangement.
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Academic Article
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Signal joint formation is inhibited in murine scid preB cells and fibroblasts in substrates with homopolymeric coding ends.
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Academic Article
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A point mutation in the constant region of Ig lambda1 prevents normal B cell development due to defective BCR signaling.
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Academic Article
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Two conserved essential motifs of the murine immunoglobulin lambda enhancers bind B-cell-specific factors.
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Academic Article
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The E box motif CAGGTG enhances somatic hypermutation without enhancing transcription.
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Academic Article
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Ig gene somatic hypermutation in mice defective for DNA polymerase delta proofreading.
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Academic Article
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Immunology. Autoreactive B cells migrate into T cell territory.
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Academic Article
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Delay of early B-lymphocyte development by gamma 2b immunoglobulin transgene: effect on differentiation-specific molecules.
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Academic Article
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Scarcity of lambda 1 B cells in mice with a single point mutation in C lambda 1 is due to a low BCR signal caused by misfolded lambda 1 light chain.
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Academic Article
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The published data.
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Academic Article
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Factors affecting the rearrangement efficiency of an Ig test gene.
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Academic Article
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Expression of AID transgene is regulated in activated B cells but not in resting B cells and kidney.
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Academic Article
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A novel enhancer in the immunoglobulin lambda locus is duplicated and functionally independent of NF kappa B.
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Academic Article
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Differential splicing of thymosin beta 4 mRNA.
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Academic Article
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Transgenic mice with mu and kappa genes encoding antiphosphorylcholine antibodies.
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Academic Article
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Brca1 in immunoglobulin gene conversion and somatic hypermutation.
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Academic Article
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Expression of immunoglobulin and globin genes in B and T lymphocytes and other cells.
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Academic Article
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The switch region associated with immunoglobulin C mu genes is DNase I hypersensitive in T lymphocytes.
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Academic Article
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Asymmetric processing of coding ends and the effect of coding end nucleotide composition on V(D)J recombination.
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Academic Article
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Alteration of the B cell surface phenotype, immune response to phosphocholine and the B cell repertoire in M167 mu plus kappa transgenic mice.
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Academic Article
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Elevated PC responsive B cells and anti-PC antibody production in transgenic mice harboring anti-PC immunoglobulin genes.
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Academic Article
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Allelic exclusion and control of endogenous immunoglobulin gene rearrangement in kappa transgenic mice.
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Academic Article
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Kinetics of mouse spleen cell populations during the immune response.
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Academic Article
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Ig lambda-producing B cells do not show feedback inhibition of gene rearrangement.
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Academic Article
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Direct demonstration of immunoglobulin kappa chain RNA in thymus T cells by in situ hybridization.
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Academic Article
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Sequences related to immunoglobulin kappa chain messenger RNA in T cells.
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Academic Article
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Immunoglobulin gene 'remnant' DNA--implications for antibody gene recombination.
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Academic Article
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Nucleosome stability dramatically impacts the targeting of somatic hypermutation.
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Academic Article
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Gamma 2b transgenic mice as a model for the role of immunoglobulins in B cell development.
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Academic Article
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Pip, a novel IRF family member, is a lymphoid-specific, PU.1-dependent transcriptional activator.
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Academic Article
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lambda 5, but not mu, is required for B cell maturation in a unique gamma 2b transgenic mouse line.
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Academic Article
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Expression, allelic exclusion and somatic mutation of mouse immunoglobulin kappa genes.
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Academic Article
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Transgenic mice with immunoglobulin genes.
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Academic Article
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Immunoglobulin messenger RNAs of T lymphocytes.
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Academic Article
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Fusion of a scid pre-B cells with a wild type (myeloma) B cell results in correct rearrangement of a V(D)J recombination substrate.
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Academic Article
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Lymphocyte development.
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Academic Article
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Antibody-carrying cells in the immune response 1. Identification of "rosette"-forming cells by light microscopy.
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Academic Article
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Immunoglobulin mu- and gamma-ribonucleic acid sequences in thymocytes and splenocytes from normal and hyperimmune mice.
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Academic Article
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RNA sequences homologous to the 3' portion of immunoglobulin alpha-chain mRNA in thymus-derived lymphocytes.
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Academic Article
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Expression of lambda and kappa genes can occur in all B cells and is initiated around the same pre-B-cell developmental stage.
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Academic Article
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Immunoglobulin gamma 2b transgenes inhibit heavy chain gene rearrangement, but cannot promote B cell development.
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Academic Article
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Attracting AID to targets of somatic hypermutation.
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Academic Article
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Ultrastructure of rosette-forming cells in the mouse during the antibody response.
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Academic Article
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Methylation patterns of immunoglobulin genes in lymphoid cells: correlation of expression and differentiation with undermethylation.
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Academic Article
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Pip, a lymphoid-restricted IRF, contains a regulatory domain that is important for autoinhibition and ternary complex formation with the Ets factor PU.1.
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Academic Article
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Crossing the SJL lambda locus into kappa-knockout mice reveals a dysfunction of the lambda 1-containing immunoglobulin receptor in B cell differentiation.
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Academic Article
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Different mismatch repair deficiencies all have the same effects on somatic hypermutation: intact primary mechanism accompanied by secondary modifications.
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Academic Article
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The C(H)1 and transmembrane domains of mu in the context of a gamma2b transgene do not suffice to promote B cell maturation.
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Academic Article
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The transcription factor Spi-B is not required for somatic hypermutation.
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Academic Article
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Steps in the generation of autoantibodies.
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Academic Article
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Precursors of both conventional and Ly-1 B cells can escape feedback inhibition of Ig gene rearrangement.
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Academic Article
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Inhibition of immunoglobulin gene rearrangement by the expression of a lambda 2 transgene.
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Academic Article
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Expression of immunoglobulin genes in transgenic mice and transfected cells.
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Academic Article
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High-frequency deletional rearrangement of immunoglobulin kappa gene segments introduced into a pre-B-cell line.
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Academic Article
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Feedback inhibition of immunoglobulin gene rearrangement by membrane mu, but not by secreted mu heavy chains.
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Academic Article
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B cells expressing Ig transgenes respond to a T-dependent antigen only in the presence of Ia-compatible T cells.
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Academic Article
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Pre-B cells in kappa-transgenic mice.
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Academic Article
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High expression of cloned immunoglobulin kappa gene in transgenic mice is restricted to B lymphocytes.
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Academic Article
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Immunoglobulin synthesis by T cells: quantitative and qualitative aspects.
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Academic Article
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Antibody-carrying cells in the immune response II. Ultrastructure of "rosette"-forming cells.
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Academic Article
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Changes in RNA polymerase II progression influence somatic hypermutation of Ig-related genes by AID.
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Academic Article
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Why does somatic hypermutation by AID require transcription of its target genes?
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Academic Article
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Delayed hypersensitivity in vitro.
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Grant
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T LYMPHOCYTE SPECIFIC GENES
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Grant
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AID in somatic mutation of immunoglobulin genes
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Grant
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Immunoglobulin Somatic Mutation
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