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Pekow, Joel R.
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overview The main focus of this laboratory is to investigate mechanisms of predictors of disease progression, response to therapy, and colon cancer development in patients with inflammatory bowel disease.
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Concept Colon
Academic Article miR-143 and miR-145 are downregulated in ulcerative colitis: putative regulators of inflammation and protooncogenes.
Academic Article EGFR signals downregulate tumor suppressors miR-143 and miR-145 in Western diet-promoted murine colon cancer: role of G1 regulators.
Academic Article Chitinase 3-like-1 expression in colonic epithelial cells as a potentially novel marker for colitis-associated neoplasia.
Academic Article Gene signature distinguishes patients with chronic ulcerative colitis harboring remote neoplastic lesions.
Academic Article The renin-angiotensin system mediates EGF receptor-vitamin d receptor cross-talk in colitis-associated colon cancer.
Academic Article Intestinal epithelial vitamin D receptor signaling inhibits experimental colitis.
Academic Article Tumor suppressors miR-143 and miR-145 and predicted target proteins API5, ERK5, K-RAS, and IRS-1 are differentially expressed in proximal and distal colon.
Academic Article Activation of the Renin-Angiotensin System Promotes Colitis Development.
Academic Article Serum 25-hydroxyvitamin D concentration is inversely associated with mucosal inflammation in patients with ulcerative colitis.
Academic Article ADAM17 is a Tumor Promoter and Therapeutic Target in Western Diet-associated Colon Cancer.
Academic Article miR-193a-3p is a Key Tumor Suppressor in Ulcerative Colitis-Associated Colon Cancer and Promotes Carcinogenesis through Upregulation of IL17RD.
Academic Article Patients With Ulcerative Colitis and Primary Sclerosing Cholangitis Frequently Have Subclinical Inflammation in the Proximal Colon.
Academic Article A comparison of the risk of postoperative recurrence between African-American and Caucasian patients with Crohn's disease.
Academic Article Identification of novel mRNAs and lncRNAs associated with mouse experimental colitis and human inflammatory bowel disease.
Academic Article IBD-associated Colon Cancers Differ in DNA Methylation and Gene Expression Profiles Compared With Sporadic Colon Cancers.
Academic Article Differential risk of disease progression between isolated anastomotic ulcers and mild ileal recurrence after ileocolonic resection in patients with Crohn's disease.
Academic Article Renin-angiotensin system promotes colonic inflammation by inducing TH17 activation via JAK2/STAT pathway.
Academic Article Losartan and Vitamin D Inhibit Colonic Tumor Development in a Conditional Apc-Deleted Mouse Model of Sporadic Colon Cancer.
Academic Article Upregulation of polycistronic microRNA-143 and microRNA-145 in colonocytes suppresses colitis and inflammation-associated colon cancer.
Academic Article Predictability of simple endoscopic score for Crohn's disease for postoperative outcomes in Crohn's disease.
Academic Article Comparison of the Risk of Crohn's Disease Postoperative Recurrence Between Modified Rutgeerts Score i2a and i2b Categories: An Individual Patient Data Meta-analysis.
Academic Article N6-adenomethylation of GsdmC is essential for Lgr5+ stem cell survival to maintain normal colonic epithelial morphogenesis.
Academic Article Pathways Related to Colon Inflammation Are Associated with Colorectal Carcinoma: A Transcriptome- and Methylome-Wide Study.
Academic Article Inflammation in the proximal colon is a risk factor for the development of colorectal neoplasia in inflammatory bowel disease patients with primary sclerosing cholangitis.
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  • Colon