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Piccirilli, Joseph A.
One or more keywords matched the following items that are connected to Piccirilli, Joseph A.
Item TypeName
Concept Hydrogen Bonding
Academic Article Leaving group stabilization by metal ion coordination and hydrogen bond donation is an evolutionarily conserved feature of group I introns.
Academic Article The role of the cleavage site 2'-hydroxyl in the Tetrahymena group I ribozyme reaction.
Academic Article Investigation of the proposed interdomain ribose zipper in hairpin ribozyme cleavage using 2'-modified nucleosides.
Academic Article Enzymatic incorporation of a new base pair into DNA and RNA extends the genetic alphabet.
Academic Article A packing-density metric for exploring the interior of folded RNA molecules.
Academic Article An atomic mutation cycle for exploring RNA's 2'-hydroxyl group.
Academic Article Synthesis and biochemical application of 2'-O-methyl-3'-thioguanosine as a probe to explore group I intron catalysis.
Academic Article Structure and function converge to identify a hydrogen bond in a group I ribozyme active site.
Academic Article Crystal structure of the catalytic core of an RNA-polymerase ribozyme.
Academic Article Synthesis of 2'-N-methylamino-2'-deoxyguanosine and 2'-N,N-dimethylamino-2'-deoxyguanosine and their incorporation into RNA by phosphoramidite chemistry.
Academic Article 2'-Fluoro substituents can mimic native 2'-hydroxyls within structured RNA.
Academic Article Kinetic characterization of the second step of group II intron splicing: role of metal ions and the cleavage site 2'-OH in catalysis.
Academic Article New strategies for exploring RNA's 2'-OH expose the importance of solvent during group II intron catalysis.
Academic Article The 2'-hydroxyl group of the guanosine nucleophile donates a functionally important hydrogen bond in the tetrahymena ribozyme reaction.
Academic Article A G-quadruplex-containing RNA activates fluorescence in a GFP-like fluorophore.
Academic Article Determination of hepatitis delta virus ribozyme N(-1) nucleobase and functional group specificity using internal competition kinetics.
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  • Hydrogen Bonding