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Piccirilli, Joseph A.
One or more keywords matched the following items that are connected to Piccirilli, Joseph A.
Item TypeName
Concept Kinetics
Academic Article Three metal ions at the active site of the Tetrahymena group I ribozyme.
Academic Article Aminoacyl esterase activity of the Tetrahymena ribozyme.
Academic Article Metal ion coordination by the AGC triad in domain 5 contributes to group II intron catalysis.
Academic Article Abortive products as initiating nucleotides during transcription by T7 RNA polymerase.
Academic Article The role of the cleavage site 2'-hydroxyl in the Tetrahymena group I ribozyme reaction.
Academic Article Active site constraints in the hydrolysis reaction catalyzed by bacterial RNase P: analysis of precursor tRNAs with a single 3'-S-phosphorothiolate internucleotide linkage.
Academic Article Investigation of the proposed interdomain ribose zipper in hairpin ribozyme cleavage using 2'-modified nucleosides.
Academic Article The tetrahymena ribozyme cleaves a 5'-methylene phosphonate monoester approximately 10(2)-fold faster than a normal phosphate diester: implications for enzyme catalysis of phosphoryl transfer reactions.
Academic Article Synthetic antibodies for specific recognition and crystallization of structured RNA.
Academic Article Ribozyme-catalyzed and nonenzymatic reactions of phosphate diesters: rate effects upon substitution of sulfur for a nonbridging phosphoryl oxygen atom.
Academic Article Nucleobase-mediated general acid-base catalysis in the Varkud satellite ribozyme.
Academic Article Kinetic isotope effects for RNA cleavage by 2'-O- transphosphorylation: nucleophilic activation by specific base.
Academic Article Reactions of phosphate and phosphorothiolate diesters with nucleophiles: comparison of transition state structures.
Academic Article The ribotoxin restrictocin recognizes its RNA substrate by selective engagement of active site residues.
Academic Article Characterization of the reaction path and transition states for RNA transphosphorylation models from theory and experiment.
Academic Article Tightening of active site interactions en route to the transition state revealed by single-atom substitution in the guanosine-binding site of the Tetrahymena group I ribozyme.
Academic Article Recognition of guanosine by dissimilar tRNA methyltransferases.
Academic Article Kinetic characterization of the second step of group II intron splicing: role of metal ions and the cleavage site 2'-OH in catalysis.
Academic Article Electrostatic interactions guide the active site face of a structure-specific ribonuclease to its RNA substrate.
Academic Article A rearrangement of the guanosine-binding site establishes an extended network of functional interactions in the Tetrahymena group I ribozyme active site.
Academic Article Isoform-specific monobody inhibitors of small ubiquitin-related modifiers engineered using structure-guided library design.
Academic Article Arginine as a general acid catalyst in serine recombinase-mediated DNA cleavage.
Academic Article Experimental and computational analysis of the transition state for ribonuclease A-catalyzed RNA 2'-O-transphosphorylation.
Academic Article Determination of hepatitis delta virus ribozyme N(-1) nucleobase and functional group specificity using internal competition kinetics.
Academic Article Heavy atom labeled nucleotides for measurement of kinetic isotope effects.
Academic Article Enzyme transition states from theory and experiment.
Academic Article Integration of kinetic isotope effect analyses to elucidate ribonuclease mechanism.
Academic Article Effect of Zn2+ binding and enzyme active site on the transition state for RNA 2'-O-transphosphorylation interpreted through kinetic isotope effects.
Academic Article Specific Recognition of a Single-Stranded RNA Sequence by a Synthetic Antibody Fragment.
Academic Article Laboratory evolution of artificially expanded DNA gives redesignable aptamers that target the toxic form of anthrax protective antigen.
Academic Article Kinetic Isotope Effect Analysis of RNA 2'-O-Transphosphorylation.
Academic Article Comparison of the Structures and Mechanisms of the Pistol and Hammerhead Ribozymes.
Academic Article Synthetic Antibody Binding to a Preorganized RNA Domain of Hepatitis C Virus Internal Ribosome Entry Site Inhibits Translation.
Academic Article The Positively Charged Active Site of the Bacterial Toxin RelE Causes a Large Shift in the General Base pKa.
Academic Article Dissociative Transition State in Hepatitis Delta Virus Ribozyme Catalysis.
Academic Article Rapid Kinetics of Pistol Ribozyme: Insights into Limits to RNA Catalysis.
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