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Piccirilli, Joseph A.
One or more keywords matched the following items that are connected to Piccirilli, Joseph A.
Item TypeName
Concept Models, Chemical
Academic Article Leaving group stabilization by metal ion coordination and hydrogen bond donation is an evolutionarily conserved feature of group I introns.
Academic Article Active site constraints in the hydrolysis reaction catalyzed by bacterial RNase P: analysis of precursor tRNAs with a single 3'-S-phosphorothiolate internucleotide linkage.
Academic Article The tetrahymena ribozyme cleaves a 5'-methylene phosphonate monoester approximately 10(2)-fold faster than a normal phosphate diester: implications for enzyme catalysis of phosphoryl transfer reactions.
Academic Article A second divalent metal ion in the group II intron reaction center.
Academic Article Identification of catalytic metal ion ligands in ribozymes.
Academic Article Experimental and computational analysis of the transition state for ribonuclease A-catalyzed RNA 2'-O-transphosphorylation.
Academic Article Heavy atom labeled nucleotides for measurement of kinetic isotope effects.
Academic Article Enzyme transition states from theory and experiment.
Academic Article Integration of kinetic isotope effect analyses to elucidate ribonuclease mechanism.
Academic Article Effect of Zn2+ binding and enzyme active site on the transition state for RNA 2'-O-transphosphorylation interpreted through kinetic isotope effects.
Academic Article Kinetic Isotope Effect Analysis of RNA 2'-O-Transphosphorylation.
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  • Models Chemical