Item Type | Name |
Concept
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RNA Ligase (ATP)
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Concept
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RNA Precursors
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Concept
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RNA, Fungal
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Concept
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RNA, Transfer, Amino Acyl
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Concept
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RNA, Transfer, Met
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Concept
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RNA-Directed DNA Polymerase
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Concept
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RNA, Bacterial
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Concept
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RNA, Viral
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Concept
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RNA Probes
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Concept
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RNA Splicing
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Concept
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RNA
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Concept
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DNA-Directed RNA Polymerases
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Concept
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RNA Processing, Post-Transcriptional
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Concept
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RNA, Transfer
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Concept
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RNA Splice Sites
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Concept
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RNA, Catalytic
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Concept
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RNA-Binding Proteins
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Concept
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RNA Cleavage
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Concept
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RNA Helicases
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Concept
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RNA Caps
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Concept
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RNA, Messenger
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Concept
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Regulatory Sequences, Ribonucleic Acid
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Concept
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RNA, Plant
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Concept
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RNA, Untranslated
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Concept
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RNA Folding
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Concept
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DEAD-box RNA Helicases
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Concept
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RNA, Small Nuclear
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Concept
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RNA, Protozoan
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Academic Article
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RNA catalysis by a group I ribozyme. Developing a model for transition state stabilization.
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Academic Article
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Metal ion catalysis in the Tetrahymena ribozyme reaction.
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Academic Article
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Three metal ions at the active site of the Tetrahymena group I ribozyme.
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Academic Article
|
Synthesis of 3'-thioribonucleosides and their incorporation into oligoribonucleotides via phosphoramidite chemistry.
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Academic Article
|
A new metal ion interaction in the Tetrahymena ribozyme reaction revealed by double sulfur substitution.
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Academic Article
|
Aminoacyl esterase activity of the Tetrahymena ribozyme.
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Academic Article
|
Metal ion catalysis during splicing of premessenger RNA.
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Academic Article
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Abortive products as initiating nucleotides during transcription by T7 RNA polymerase.
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Academic Article
|
Leaving group stabilization by metal ion coordination and hydrogen bond donation is an evolutionarily conserved feature of group I introns.
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Academic Article
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The role of the cleavage site 2'-hydroxyl in the Tetrahymena group I ribozyme reaction.
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Academic Article
|
Metal ion catalysis during group II intron self-splicing: parallels with the spliceosome.
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Academic Article
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Active site constraints in the hydrolysis reaction catalyzed by bacterial RNase P: analysis of precursor tRNAs with a single 3'-S-phosphorothiolate internucleotide linkage.
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Academic Article
|
Metal ion catalysis during the exon-ligation step of nuclear pre-mRNA splicing: extending the parallels between the spliceosome and group II introns.
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Academic Article
|
Investigation of the proposed interdomain ribose zipper in hairpin ribozyme cleavage using 2'-modified nucleosides.
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Academic Article
|
Enzymatic incorporation of a new base pair into DNA and RNA extends the genetic alphabet.
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Academic Article
|
A C-nucleotide base pair: methylpseudouridine-directed incorporation of formycin triphosphate into RNA catalyzed by T7 RNA polymerase.
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Academic Article
|
Identification of an active site ligand for a group I ribozyme catalytic metal ion.
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Academic Article
|
Synthesis of the phosphoramidite derivatives of 2'-deoxy-2'-C-alpha-methylcytidine and 2'-deoxy-2'-C-alpha-hydroxymethylcytidine: analogues for chemical dissection of RNA's 2'-hydroxyl group.
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Academic Article
|
The tetrahymena ribozyme cleaves a 5'-methylene phosphonate monoester approximately 10(2)-fold faster than a normal phosphate diester: implications for enzyme catalysis of phosphoryl transfer reactions.
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Academic Article
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A packing-density metric for exploring the interior of folded RNA molecules.
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Academic Article
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Synthesis of 2'-C-difluoromethylribonucleosides and their enzymatic incorporation into oligonucleotides.
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Academic Article
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Synthesis of 2'-C-alpha-(hydroxyalkyl) and 2'-C-alpha-alkylcytidine phosphoramidites: analogues for probing solvent interactions with RNA.
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Academic Article
|
A second divalent metal ion in the group II intron reaction center.
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Academic Article
|
General acid catalysis by the hepatitis delta virus ribozyme.
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Academic Article
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2'-mercaptonucleotide interference reveals regions of close packing within folded RNA molecules.
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Academic Article
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A systematic, ligation-based approach to study RNA modifications.
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Academic Article
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'Turning on' riboswitches to their antibacterial potential.
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Academic Article
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Synthetic antibodies for specific recognition and crystallization of structured RNA.
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Academic Article
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Identification of recognition residues for ligation-based detection and quantitation of pseudouridine and N6-methyladenosine.
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Academic Article
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Synthesis and biochemical application of 2'-O-methyl-3'-thioguanosine as a probe to explore group I intron catalysis.
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Academic Article
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Evidence for the importance of electrostatics in the function of two distinct families of ribosome inactivating toxins.
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Academic Article
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Identification of catalytic metal ion ligands in ribozymes.
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Academic Article
|
Structure and function converge to identify a hydrogen bond in a group I ribozyme active site.
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Academic Article
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Ribozyme-catalyzed and nonenzymatic reactions of phosphate diesters: rate effects upon substitution of sulfur for a nonbridging phosphoryl oxygen atom.
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Academic Article
|
Crystal structure of the catalytic core of an RNA-polymerase ribozyme.
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Academic Article
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Nucleotide analogues to investigate RNA structure and function.
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Academic Article
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Nucleobase-mediated general acid-base catalysis in the Varkud satellite ribozyme.
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Academic Article
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Kinetic isotope effects for RNA cleavage by 2'-O- transphosphorylation: nucleophilic activation by specific base.
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Academic Article
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The mechanism of RNA strand scission: an experimental measure of the Brønsted coefficient, beta nuc.
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Academic Article
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Syntheses of (2')3'-15N-amino-(2')3'-deoxyguanosine and determination of their pKa values by 15N NMR spectroscopy.
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Academic Article
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2'-amino-modified ribonucleotides as probes for local interactions within RNA.
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Academic Article
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Linkage between substrate recognition and catalysis during cleavage of sarcin/ricin loop RNA by restrictocin.
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Academic Article
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Biochemistry. Toward understanding self-splicing.
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Academic Article
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Functional identification of ligands for a catalytic metal ion in group I introns.
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Academic Article
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A general and efficient approach for the construction of RNA oligonucleotides containing a 5'-phosphorothiolate linkage.
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Academic Article
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Thermodynamic evidence for negative charge stabilization by a catalytic metal ion within an RNA active site.
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Academic Article
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The ribotoxin restrictocin recognizes its RNA substrate by selective engagement of active site residues.
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Academic Article
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The mechanism of peptidyl transfer catalysis by the ribosome.
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Academic Article
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Synthesis of 2'-N-methylamino-2'-deoxyguanosine and 2'-N,N-dimethylamino-2'-deoxyguanosine and their incorporation into RNA by phosphoramidite chemistry.
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Academic Article
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Characterization of the reaction path and transition states for RNA transphosphorylation models from theory and experiment.
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Academic Article
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Automated solid-phase synthesis of RNA oligonucleotides containing a nonbridging phosphorodithioate linkage via phosphorothioamidites.
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Academic Article
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Tightening of active site interactions en route to the transition state revealed by single-atom substitution in the guanosine-binding site of the Tetrahymena group I ribozyme.
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Academic Article
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Natural selection, protein engineering, and the last riboorganism: rational model building in biochemistry.
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Academic Article
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Metal-ion rescue revisited: biochemical detection of site-bound metal ions important for RNA folding.
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Academic Article
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2'-Fluoro substituents can mimic native 2'-hydroxyls within structured RNA.
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Academic Article
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Recognition of guanosine by dissimilar tRNA methyltransferases.
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Academic Article
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Crystal structure of an RNA polymerase ribozyme in complex with an antibody fragment.
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Academic Article
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Origin of life. RNA seeks its maker.
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Academic Article
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Modulation of individual steps in group I intron catalysis by a peripheral metal ion.
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Academic Article
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The DEAH box ATPases Prp16 and Prp43 cooperate to proofread 5' splice site cleavage during pre-mRNA splicing.
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Academic Article
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Separation of RNA phosphorothioate oligonucleotides by HPLC.
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Academic Article
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Kinetic characterization of the second step of group II intron splicing: role of metal ions and the cleavage site 2'-OH in catalysis.
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Academic Article
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Defining the catalytic metal ion interactions in the Tetrahymena ribozyme reaction.
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Academic Article
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New strategies for exploring RNA's 2'-OH expose the importance of solvent during group II intron catalysis.
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Academic Article
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Functional identification of catalytic metal ion binding sites within RNA.
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Academic Article
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Structural inference of native and partially folded RNA by high-throughput contact mapping.
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Academic Article
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The 2'-hydroxyl group of the guanosine nucleophile donates a functionally important hydrogen bond in the tetrahymena ribozyme reaction.
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Academic Article
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Electrostatic interactions guide the active site face of a structure-specific ribonuclease to its RNA substrate.
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Academic Article
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Synthesis of pyridine, pyrimidine and pyridinone C-nucleoside phosphoramidites for probing cytosine function in RNA.
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Academic Article
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A rearrangement of the guanosine-binding site establishes an extended network of functional interactions in the Tetrahymena group I ribozyme active site.
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Academic Article
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A portable RNA sequence whose recognition by a synthetic antibody facilitates structural determination.
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Academic Article
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Synthesis, properties, and applications of oligonucleotides containing an RNA dinucleotide phosphorothiolate linkage.
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Academic Article
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Chemical origins of life: Prebiotic RNA unstuck.
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Academic Article
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A G-quadruplex-containing RNA activates fluorescence in a GFP-like fluorophore.
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Academic Article
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Altered (transition) states: mechanisms of solution and enzyme catalyzed RNA 2'-O-transphosphorylation.
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Academic Article
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Experimental and computational analysis of the transition state for ribonuclease A-catalyzed RNA 2'-O-transphosphorylation.
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Academic Article
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Origins of life: RNA made in its own mirror image.
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Academic Article
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Spinach RNA aptamer detects lead(II) with high selectivity.
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Academic Article
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Synthesis of 2'-O-photocaged ribonucleoside phosphoramidites.
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Academic Article
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RNA catalyses nuclear pre-mRNA splicing.
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Academic Article
|
Synthesis and incorporation of the phosphoramidite derivative of 2'-O-photocaged 3'-s-thioguanosine into oligoribonucleotides: substrate for probing the mechanism of RNA catalysis.
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Academic Article
|
Evidence for a group II intron-like catalytic triplex in the spliceosome.
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Academic Article
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Determination of hepatitis delta virus ribozyme N(-1) nucleobase and functional group specificity using internal competition kinetics.
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Academic Article
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Transition State Features in the Hepatitis Delta Virus Ribozyme Reaction Revealed by Atomic Perturbations.
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Academic Article
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A Crystal Structure of a Functional RNA Molecule Containing an Artificial Nucleobase Pair.
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Academic Article
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Integration of kinetic isotope effect analyses to elucidate ribonuclease mechanism.
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Academic Article
|
Effect of Zn2+ binding and enzyme active site on the transition state for RNA 2'-O-transphosphorylation interpreted through kinetic isotope effects.
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Academic Article
|
Crystal structure of the Varkud satellite ribozyme.
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Academic Article
|
An active site rearrangement within the Tetrahymena group I ribozyme releases nonproductive interactions and allows formation of catalytic interactions.
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Academic Article
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Isotope effect analyses provide evidence for an altered transition state for RNA 2'-O-transphosphorylation catalyzed by Zn(2+).
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Academic Article
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Reverse transcriptases lend a hand in splicing catalysis.
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Academic Article
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Specific Recognition of a Single-Stranded RNA Sequence by a Synthetic Antibody Fragment.
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Academic Article
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Drug conjugated nanoparticles activated by cancer cell specific mRNA.
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Academic Article
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RNA-Puzzles Round III: 3D RNA structure prediction of five riboswitches and one ribozyme.
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Academic Article
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Synthesizing topological structures containing RNA.
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Academic Article
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Structural Basis for Substrate Helix Remodeling and Cleavage Loop Activation in the Varkud Satellite Ribozyme.
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Academic Article
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Structural basis for activation of fluorogenic dyes by an RNA aptamer lacking a G-quadruplex motif.
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Academic Article
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Evidence That Nucleophile Deprotonation Exceeds Bond Formation in the HDV Ribozyme Transition State.
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Academic Article
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Kinetic Isotope Effect Analysis of RNA 2'-O-Transphosphorylation.
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Academic Article
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Affinity maturation of a portable Fab-RNA module for chaperone-assisted RNA crystallography.
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Academic Article
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Hachimoji DNA and RNA: A genetic system with eight building blocks.
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Academic Article
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An Ontology for Facilitating Discussion of Catalytic Strategies of RNA-Cleaving Enzymes.
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Academic Article
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A conserved RNA structural motif for organizing topology within picornaviral internal ribosome entry sites.
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Academic Article
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The L-platform/L-scaffold framework: a blueprint for RNA-cleaving nucleic acid enzyme design.
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Academic Article
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Synthetic Antibody Binding to a Preorganized RNA Domain of Hepatitis C Virus Internal Ribosome Entry Site Inhibits Translation.
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Academic Article
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Evidence for a Catalytic Strategy to Promote Nucleophile Activation in Metal-Dependent RNA-Cleaving Ribozymes and 8-17 DNAzyme.
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Academic Article
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Branched kissing loops for the construction of diverse RNA homooligomeric nanostructures.
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Academic Article
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Confluence of theory and experiment reveals the catalytic mechanism of the Varkud satellite ribozyme.
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Academic Article
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The Positively Charged Active Site of the Bacterial Toxin RelE Causes a Large Shift in the General Base pKa.
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Academic Article
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The hammerhead self-cleaving motif as a precursor to complex endonucleolytic ribozymes.
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Academic Article
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The SARS-CoV-2 Programmed -1 Ribosomal Frameshifting Element Crystal Structure Solved to 2.09 Å Using Chaperone-Assisted RNA Crystallography.
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Academic Article
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Synthesis of Oligoribonucleotides Containing a 2'-Amino-5'-S-phosphorothiolate Linkage.
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Academic Article
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Structures of artificially designed discrete RNA nanoarchitectures at near-atomic resolution.
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Academic Article
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Structural basis for substrate binding and catalysis by a self-alkylating ribozyme.
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Academic Article
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Sub-3-Å cryo-EM structure of RNA enabled by engineered homomeric self-assembly.
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Academic Article
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Structural Basis for Fluorescence Activation by Pepper RNA.
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Academic Article
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Dissociative Transition State in Hepatitis Delta Virus Ribozyme Catalysis.
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Concept
|
RNA Splicing Factors
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Academic Article
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Rapid Kinetics of Pistol Ribozyme: Insights into Limits to RNA Catalysis.
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Academic Article
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A general and efficient approach to synthesize the phosphoramidites of 5'-18O labeled purine nucleosides.
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Academic Article
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Crystal structure of a cap-independent translation enhancer RNA.
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