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Piccirilli, Joseph A.
One or more keywords matched the following items that are connected to Piccirilli, Joseph A.
Item TypeName
Concept Tetrahymena thermophila
Concept Tetrahymena
Academic Article Metal ion catalysis in the Tetrahymena ribozyme reaction.
Academic Article Three metal ions at the active site of the Tetrahymena group I ribozyme.
Academic Article A new metal ion interaction in the Tetrahymena ribozyme reaction revealed by double sulfur substitution.
Academic Article Aminoacyl esterase activity of the Tetrahymena ribozyme.
Academic Article Leaving group stabilization by metal ion coordination and hydrogen bond donation is an evolutionarily conserved feature of group I introns.
Academic Article The role of the cleavage site 2'-hydroxyl in the Tetrahymena group I ribozyme reaction.
Academic Article Identification of an active site ligand for a group I ribozyme catalytic metal ion.
Academic Article The tetrahymena ribozyme cleaves a 5'-methylene phosphonate monoester approximately 10(2)-fold faster than a normal phosphate diester: implications for enzyme catalysis of phosphoryl transfer reactions.
Academic Article Synthetic antibodies for specific recognition and crystallization of structured RNA.
Academic Article Synthesis and biochemical application of 2'-O-methyl-3'-thioguanosine as a probe to explore group I intron catalysis.
Academic Article Identification of catalytic metal ion ligands in ribozymes.
Academic Article Structure and function converge to identify a hydrogen bond in a group I ribozyme active site.
Academic Article Ribozyme-catalyzed and nonenzymatic reactions of phosphate diesters: rate effects upon substitution of sulfur for a nonbridging phosphoryl oxygen atom.
Academic Article Functional identification of ligands for a catalytic metal ion in group I introns.
Academic Article Thermodynamic evidence for negative charge stabilization by a catalytic metal ion within an RNA active site.
Academic Article Tightening of active site interactions en route to the transition state revealed by single-atom substitution in the guanosine-binding site of the Tetrahymena group I ribozyme.
Academic Article Metal-ion rescue revisited: biochemical detection of site-bound metal ions important for RNA folding.
Academic Article 2'-Fluoro substituents can mimic native 2'-hydroxyls within structured RNA.
Academic Article Modulation of individual steps in group I intron catalysis by a peripheral metal ion.
Academic Article Defining the catalytic metal ion interactions in the Tetrahymena ribozyme reaction.
Academic Article Functional identification of catalytic metal ion binding sites within RNA.
Academic Article The 2'-hydroxyl group of the guanosine nucleophile donates a functionally important hydrogen bond in the tetrahymena ribozyme reaction.
Academic Article A rearrangement of the guanosine-binding site establishes an extended network of functional interactions in the Tetrahymena group I ribozyme active site.
Academic Article An active site rearrangement within the Tetrahymena group I ribozyme releases nonproductive interactions and allows formation of catalytic interactions.
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  • Tetrahymena