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One or more keywords matched the following items that are connected to Piccirilli, Joseph A.
Item TypeName
Concept Hydrogen-Ion Concentration
Concept Hydrogen Bonding
Academic Article Leaving group stabilization by metal ion coordination and hydrogen bond donation is an evolutionarily conserved feature of group I introns.
Academic Article The role of the cleavage site 2'-hydroxyl in the Tetrahymena group I ribozyme reaction.
Academic Article Investigation of the proposed interdomain ribose zipper in hairpin ribozyme cleavage using 2'-modified nucleosides.
Academic Article Enzymatic incorporation of a new base pair into DNA and RNA extends the genetic alphabet.
Academic Article A packing-density metric for exploring the interior of folded RNA molecules.
Academic Article An atomic mutation cycle for exploring RNA's 2'-hydroxyl group.
Academic Article Synthesis and biochemical application of 2'-O-methyl-3'-thioguanosine as a probe to explore group I intron catalysis.
Academic Article Structure and function converge to identify a hydrogen bond in a group I ribozyme active site.
Academic Article Crystal structure of the catalytic core of an RNA-polymerase ribozyme.
Academic Article Nucleobase-mediated general acid-base catalysis in the Varkud satellite ribozyme.
Academic Article Kinetic isotope effects for RNA cleavage by 2'-O- transphosphorylation: nucleophilic activation by specific base.
Academic Article The mechanism of RNA strand scission: an experimental measure of the Brønsted coefficient, beta nuc.
Academic Article Syntheses of (2')3'-15N-amino-(2')3'-deoxyguanosine and determination of their pKa values by 15N NMR spectroscopy.
Academic Article The mechanism of peptidyl transfer catalysis by the ribosome.
Academic Article Synthesis of 2'-N-methylamino-2'-deoxyguanosine and 2'-N,N-dimethylamino-2'-deoxyguanosine and their incorporation into RNA by phosphoramidite chemistry.
Academic Article 2'-Fluoro substituents can mimic native 2'-hydroxyls within structured RNA.
Academic Article Kinetic characterization of the second step of group II intron splicing: role of metal ions and the cleavage site 2'-OH in catalysis.
Academic Article New strategies for exploring RNA's 2'-OH expose the importance of solvent during group II intron catalysis.
Academic Article The 2'-hydroxyl group of the guanosine nucleophile donates a functionally important hydrogen bond in the tetrahymena ribozyme reaction.
Academic Article General acid-base catalysis mediated by nucleobases in the hairpin ribozyme.
Academic Article A G-quadruplex-containing RNA activates fluorescence in a GFP-like fluorophore.
Academic Article Arginine as a general acid catalyst in serine recombinase-mediated DNA cleavage.
Academic Article Synthesis of 2'-O-photocaged ribonucleoside phosphoramidites.
Academic Article Determination of hepatitis delta virus ribozyme N(-1) nucleobase and functional group specificity using internal competition kinetics.
Academic Article The Positively Charged Active Site of the Bacterial Toxin RelE Causes a Large Shift in the General Base pKa.
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