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Search Results to Ravi Salgia

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One or more keywords matched the following items that are connected to Salgia, Ravi

Item TypeName
Concept Oncogenes
Concept Proto-Oncogene Proteins
Concept Oncogene Proteins v-abl
Concept Oncogene Proteins
Concept Oncogene Proteins, Fusion
Concept Proto-Oncogene Proteins c-fos
Concept Proto-Oncogene Proteins c-abl
Concept Proto-Oncogene Proteins c-crk
Concept Proto-Oncogene Proteins c-vav
Concept Oncogene Proteins, Viral
Concept Proto-Oncogene Proteins c-pim-1
Concept Proto-Oncogene Proteins c-bcl-2
Concept Proto-Oncogene Proteins c-raf
Concept Proto-Oncogene Proteins B-raf
Concept Proto-Oncogene Proteins c-kit
Concept Proto-Oncogene Proteins c-ret
Concept Proto-Oncogene Proteins c-cbl
Concept Proto-Oncogene Proteins p21(ras)
Concept Proto-Oncogene Proteins c-met
Concept Oncogene Protein v-cbl
Concept Proto-Oncogene Proteins c-fyn
Concept Proto-Oncogene Proteins c-akt
Academic Article p210BCR/ABL induces formation of complexes containing focal adhesion proteins and the protooncogene product p120c-Cbl.
Academic Article Steel factor induces tyrosine phosphorylation of CRKL and binding of CRKL to a complex containing c-kit, phosphatidylinositol 3-kinase, and p120(CBL).
Academic Article Activation of hematopoietic growth factor signal transduction pathways by the human oncogene BCR/ABL.
Academic Article p130CAS forms a signaling complex with the adapter protein CRKL in hematopoietic cells transformed by the BCR/ABL oncogene.
Academic Article BCR/ABL induces multiple abnormalities of cytoskeletal function.
Academic Article The phosphatidylinositol polyphosphate 5-phosphatase SHIP and the protein tyrosine phosphatase SHP-2 form a complex in hematopoietic cells which can be regulated by BCR/ABL and growth factors.
Academic Article The proto-oncogene product p120CBL and the adaptor proteins CRKL and c-CRK link c-ABL, p190BCR/ABL and p210BCR/ABL to the phosphatidylinositol-3' kinase pathway.
Academic Article The BCR/ABL oncogene alters interaction of the adapter proteins CRKL and CRK with cellular proteins.
Academic Article Tyrosine phosphorylation of the product of the c-cbl protooncogene is [corrected] induced after integrin stimulation.
Academic Article Hematopoietic growth factors signal through the formation of reactive oxygen species.
Academic Article Role of focal adhesion proteins in signal transduction and oncogenesis.
Academic Article Thrombopoietin induces activation of the phosphatidylinositol-3' kinase pathway and formation of a complex containing p85PI3K and the protooncoprotein p120CBL.
Academic Article The bovine papillomavirus E6 protein binds to the LD motif repeats of paxillin and blocks its interaction with vinculin and the focal adhesion kinase.
Academic Article Growth inhibition and modulation of kinase pathways of small cell lung cancer cell lines by the novel tyrosine kinase inhibitor STI 571.
Academic Article The BCR/ABL oncogene alters the chemotactic response to stromal-derived factor-1alpha.
Academic Article Molecular abnormalities in lung cancer.
Academic Article Expression of the focal adhesion protein paxillin in lung cancer and its relation to cell motility.
Academic Article Vascular endothelial growth factor-induced migration of multiple myeloma cells is associated with beta 1 integrin- and phosphatidylinositol 3-kinase-dependent PKC alpha activation.
Academic Article Differential expression and signaling of CBL and CBL-B in BCR/ABL transformed cells.
Academic Article SHIP1, an SH2 domain containing polyinositol-5-phosphatase, regulates migration through two critical tyrosine residues and forms a novel signaling complex with DOK1 and CRKL.
Academic Article Regulation of cellular proliferation, cytoskeletal function, and signal transduction through CXCR4 and c-Kit in small cell lung cancer cells.
Academic Article Role of the hepatocyte growth factor receptor, c-Met, in oncogenesis and potential for therapeutic inhibition.
Academic Article Modulation of the c-Met/hepatocyte growth factor pathway in small cell lung cancer.
Academic Article Role of receptor tyrosine kinases in lung cancer.
Academic Article Activated c-Met signals through PI3K with dramatic effects on cytoskeletal functions in small cell lung cancer.
Academic Article c-MET mutational analysis in small cell lung cancer: novel juxtamembrane domain mutations regulating cytoskeletal functions.
Academic Article 2-methoxyestradiol alters cell motility, migration, and adhesion.
Academic Article Molecular alterations in lung cancer. Impact on prognosis.
Academic Article Targeted molecules in small cell lung cancer.
Academic Article Targeting c-Kit mutations: basic science to novel therapies.
Academic Article Phase II study of imatinib in patients with small cell lung cancer.
Academic Article Therapeutic targeting of the receptor tyrosine kinase Met.
Academic Article A selective small molecule c-MET Inhibitor, PHA665752, cooperates with rapamycin.
Academic Article Functional expression and mutations of c-Met and its therapeutic inhibition with SU11274 and small interfering RNA in non-small cell lung cancer.
Academic Article c-Met as a target for human cancer and characterization of inhibitors for therapeutic intervention.
Academic Article Expression of Siva-1 protein or its putative amphipathic helical region enhances cisplatin-induced apoptosis in breast cancer cells: effect of elevated levels of BCL-2.
Academic Article Activation of HGF/c-Met pathway contributes to the reactive oxygen species generation and motility of small cell lung cancer cells.
Academic Article A selective small molecule inhibitor of c-Met, PHA665752, inhibits tumorigenicity and angiogenesis in mouse lung cancer xenografts.
Academic Article c-Met inhibition.
Academic Article c-Met: structure, functions and potential for therapeutic inhibition.
Academic Article c-Met and hepatocyte growth factor: potential as novel targets in cancer therapy.
Academic Article PAX5 is expressed in small-cell lung cancer and positively regulates c-Met transcription.
Academic Article MET as a target for treatment of chest tumors.
Academic Article The MET receptor tyrosine kinase is a potential novel therapeutic target for head and neck squamous cell carcinoma.
Academic Article Expression and mutational analysis of MET in human solid cancers.
Academic Article MET pathway as a therapeutic target.
Academic Article Role of c-Met in cancer: emphasis on lung cancer.
Academic Article Functional analysis of c-Met/hepatocyte growth factor pathway in malignant pleural mesothelioma.
Academic Article PAX6 is expressed in pancreatic cancer and actively participates in cancer progression through activation of the MET tyrosine kinase receptor gene.
Academic Article MET receptor tyrosine kinase.
Academic Article Ethnic differences and functional analysis of MET mutations in lung cancer.
Academic Article Fyn: a novel molecular target in cancer.
Academic Article CBL is frequently altered in lung cancers: its relationship to mutations in MET and EGFR tyrosine kinases.
Academic Article c-Met overexpression is a prognostic factor in ovarian cancer and an effective target for inhibition of peritoneal dissemination and invasion.
Academic Article Rapid and dramatic radiographic and clinical response to an ALK inhibitor (crizotinib, PF02341066) in an ALK translocation-positive patient with non-small cell lung cancer.
Academic Article Lysophosphatidic acid modulates c-Met redistribution and hepatocyte growth factor/c-Met signaling in human bronchial epithelial cells through PKC delta and E-cadherin.
Academic Article Fyn is downstream of the HGF/MET signaling axis and affects cellular shape and tropism in PC3 cells.
Academic Article Downstream signalling and specific inhibition of c-MET/HGF pathway in small cell lung cancer: implications for tumour invasion.
Academic Article Non-receptor tyrosine kinase inhibitors in lung cancer.
Academic Article FYN is overexpressed in human prostate cancer.
Academic Article Effect of a c-Met-specific, ATP-competitive small-molecule inhibitor SU11274 on human ovarian carcinoma cell growth, motility, and invasion.
Academic Article Inhibition of MET receptor tyrosine kinase and its ligand hepatocyte growth factor.
Academic Article A novel classification of lung cancer into molecular subtypes.
Academic Article Overexpression of the µ-opioid receptor in human non-small cell lung cancer promotes Akt and mTOR activation, tumor growth, and metastasis.
Academic Article PAX3 and SOX10 activate MET receptor expression in melanoma.
Academic Article Activity of XL184 (Cabozantinib), an oral tyrosine kinase inhibitor, in patients with medullary thyroid cancer.
Academic Article MET, HGF, EGFR, and PXN gene copy number in lung cancer using DNA extracts from FFPE archival samples and prognostic significance.
Academic Article MET and phosphorylated MET as potential biomarkers in lung cancer.
Academic Article Anaplastic lymphoma kinase inhibition in non-small-cell lung cancer.
Academic Article Factor independence of human myeloid leukemia cell lines is associated with increased phosphorylation of the proto-oncogene Raf-1.
Academic Article Inhibition of MET receptor tyrosine kinase and its ligand hepatocyte growth factor.
Academic Article MET amplification identifies a small and aggressive subgroup of esophagogastric adenocarcinoma with evidence of responsiveness to crizotinib.
Academic Article Tyrosine kinase mutations in human cancer.
Academic Article c-Met is a potentially new therapeutic target for treatment of human melanoma.
Academic Article The thrombopoietin receptor c-MPL activates JAK2 and TYK2 tyrosine kinases.
Academic Article Paxillin is a target for somatic mutations in lung cancer: implications for cell growth and invasion.
Academic Article Review of clinic trials: agents targeting c-Met.
Academic Article MET molecular mechanisms and therapies in lung cancer.
Academic Article Novel oncogenic mutations of CBL in human acute myeloid leukemia that activate growth and survival pathways depend on increased metabolism.
Academic Article NADPH oxidases regulate cell growth and migration in myeloid cells transformed by oncogenic tyrosine kinases.
Academic Article Personalized treatment of lung cancer.
Academic Article An E3 ubiquitin ligase: c-Cbl: a new therapeutic target of lung cancer.
Academic Article Phase II study of the multitargeted tyrosine kinase inhibitor XL647 in patients with non-small-cell lung cancer.
Academic Article Targeting ALK: a promising strategy for the treatment of non-small cell lung cancer, non-Hodgkin's lymphoma, and neuroblastoma.
Academic Article Differential signaling after beta1 integrin ligation is mediated through binding of CRKL to p120(CBL) and p110(HEF1).
Academic Article Involvement of the adapter protein CRKL in integrin-mediated adhesion.
Academic Article Molecular and cellular biology of small cell lung cancer.
Academic Article A novel small molecule met inhibitor induces apoptosis in cells transformed by the oncogenic TPR-MET tyrosine kinase.
Academic Article Mechanisms of metastasis as related to receptor tyrosine kinases in small-cell lung cancer.
Academic Article Key signaling pathways and targets in lung cancer therapy.
Academic Article CD44 regulates hepatocyte growth factor-mediated vascular integrity. Role of c-Met, Tiam1/Rac1, dynamin 2, and cortactin.
Academic Article C. elegans as a model organism for in vivo screening in cancer: effects of human c-Met in lung cancer affect C. elegans vulva phenotypes.
Academic Article Disruption of the EGFR E884-R958 ion pair conserved in the human kinome differentially alters signaling and inhibitor sensitivity.
Academic Article Expression patterns of PAX5, c-Met, and paxillin in neuroendocrine tumors of the lung.
Academic Article Paxillin expression and amplification in early lung lesions of high-risk patients, lung adenocarcinoma and metastatic disease.
Academic Article RON (MST1R) is a novel prognostic marker and therapeutic target for gastroesophageal adenocarcinoma.
Academic Article Activity of crizotinib (PF02341066), a dual mesenchymal-epithelial transition (MET) and anaplastic lymphoma kinase (ALK) inhibitor, in a non-small cell lung cancer patient with de novo MET amplification.
Academic Article Role of MetMAb (OA-5D5) in c-MET active lung malignancies.
Academic Article A phase I trial of pan-Bcl-2 antagonist obatoclax administered as a 3-h or a 24-h infusion in combination with carboplatin and etoposide in patients with extensive-stage small cell lung cancer.
Academic Article Durable complete response of metastatic gastric cancer with anti-Met therapy followed by resistance at recurrence.
Academic Article Increased tyrosine phosphorylation of focal adhesion proteins in myeloid cell lines expressing p210BCR/ABL.
Academic Article Lack of association of C-Met-N375S sequence variant with lung cancer susceptibility and prognosis.
Academic Article MET as a possible target for non-small-cell lung cancer.
Academic Article Critical role of S1PR1 and integrin ß4 in HGF/c-Met-mediated increases in vascular integrity.
Academic Article Initial clinical sensitivity and acquired resistance to MET inhibition in MET-mutated papillary renal cell carcinoma.
Academic Article Lipopolysaccharide-induced phosphorylation of c-Met tyrosine residue 1003 regulates c-Met intracellular trafficking and lung epithelial barrier function.
Academic Article Role of c-Met/phosphatidylinositol 3-kinase (PI3k)/Akt signaling in hepatocyte growth factor (HGF)-mediated lamellipodia formation, reactive oxygen species (ROS) generation, and motility of lung endothelial cells.
Academic Article Activating the expression of human K-rasG12D stimulates oncogenic transformation in transgenic goat fetal fibroblast cells.
Academic Article Analysis of 1,115 patients tested for MET amplification and therapy response in the MD Anderson Phase I Clinic.
Academic Article MET and PI3K/mTOR as a potential combinatorial therapeutic target in malignant pleural mesothelioma.
Academic Article Role of PAX8 in the regulation of MET and RON receptor tyrosine kinases in non-small cell lung cancer.
Academic Article Crizotinib in ROS1-rearranged non-small-cell lung cancer.
Academic Article Multiple Endocrine Disruption by the MET/ALK Inhibitor Crizotinib in Patients With Non-small Cell Lung Cancer.
Academic Article Combined MET inhibition and topoisomerase I inhibition block cell growth of small cell lung cancer.
Academic Article Dramatic antitumor effects of the dual MET/RON small-molecule inhibitor LY2801653 in non-small cell lung cancer.
Academic Article AXL mediates resistance to cetuximab therapy.
Academic Article Overcoming acquired resistance to cetuximab by dual targeting HER family receptors with antibody-based therapy.
Academic Article c-Abl mediated tyrosine phosphorylation of paxillin regulates LPS-induced endothelial dysfunction and lung injury.
Academic Article AXL Is a Logical Molecular Target in Head and Neck Squamous Cell Carcinoma.
Academic Article A randomized phase II study of ganetespib, a heat shock protein 90 inhibitor, in combination with docetaxel in second-line therapy of advanced non-small cell lung cancer (GALAXY-1).
Academic Article Activation of MET via diverse exon 14 splicing alterations occurs in multiple tumor types and confers clinical sensitivity to MET inhibitors.
Academic Article MET as a drug target.
Academic Article Phase II Study of the AKT Inhibitor MK-2206 plus Erlotinib in Patients with Advanced Non-Small Cell Lung Cancer Who Previously Progressed on Erlotinib.
Academic Article ROS1 rearranged non-small cell lung cancer brain metastases respond to low dose radiotherapy.
Academic Article C. elegans and mutants with chronic nicotine exposure as a novel model of cancer phenotype.
Academic Article Selumetinib with and without erlotinib in KRAS mutant and KRAS wild-type advanced nonsmall-cell lung cancer.
Academic Article Oncoprotein ZNF322A transcriptionally deregulates alpha-adducin, cyclin D1 and p53 to promote tumor growth and metastasis in lung cancer.
Academic Article Effective growth-suppressive activity of maternal embryonic leucine-zipper kinase (MELK) inhibitor against small cell lung cancer.
Academic Article Prognostic and Predictive Value in KRAS in Non-Small-Cell Lung Cancer: A Review.
Academic Article Met gene amplification and protein hyperactivation is a mechanism of resistance to both first and third generation EGFR inhibitors in lung cancer treatment.
Academic Article PI3 Kinase Pathway and MET Inhibition is Efficacious in Malignant Pleural Mesothelioma.
Academic Article The receptor tyrosine kinase AXL mediates nuclear translocation of the epidermal growth factor receptor.
Academic Article Molecular profiling of metastatic colorectal tumors using next-generation sequencing: a single-institution experience.
Academic Article Expression and mutational analysis of c-CBL and its relationship to the MET receptor in head and neck squamous cell carcinoma.
Academic Article Oncoprotein ZNF322A transcriptionally deregulates alpha-adducin, cyclin D1 and p53 to promote tumor growth and metastasis in lung cancer.
Academic Article MET in Lung Cancer: Biomarker Selection Based on Scientific Rationale.
Academic Article Oncoprotein ZNF322A transcriptionally deregulates alpha-adducin, cyclin D1 and p53 to promote tumor growth and metastasis in lung cancer.
Academic Article Differential responsiveness of MET inhibition in non-small-cell lung cancer with altered CBL.
Academic Article The brigatinib experience: a new generation of therapy for ALK-positive non-small-cell lung cancer.
Academic Article Focal adhesion kinase a potential therapeutic target for pancreatic cancer and malignant pleural mesothelioma.
Academic Article B-Cell-Specific Diversion of Glucose Carbon Utilization Reveals a Unique Vulnerability in B Cell Malignancies.
Academic Article Responses to Alectinib in ALK-rearranged Papillary Renal Cell Carcinoma.
Academic Article Synergistic efficacy of RLIP inhibition and 2'-hydroxyflavanone against DMBA-induced mammary carcinogenesis in SENCAR mice.
Academic Article Notch signaling in breast cancer: From pathway analysis to therapy.
Academic Article Dose-escalation trial of the ALK, MET & ROS1 inhibitor, crizotinib, in patients with advanced cancer.
Academic Article Precision medicine and actionable alterations in lung cancer: A single institution experience.
Academic Article Radiomic prediction of mutation status based on MR imaging of lung cancer brain metastases.
Academic Article Phase I Dose-Escalation and -Expansion Study of Telisotuzumab (ABT-700), an Anti-c-Met Antibody, in Patients with Advanced Solid Tumors.
Academic Article The promise of selective MET inhibitors in non-small cell lung cancer with MET exon 14 skipping.
Academic Article MET receptor in oncology: From biomarker to therapeutic target.
Academic Article Prolonged survival and response to tepotinib in a non-small-cell lung cancer patient with brain metastases harboring MET exon 14 mutation: a research report.
Academic Article Prevention of mammary carcinogenesis in MMTV-neu mice by targeting RLIP.

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  • Oncogenes