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Search Results to Ernst Robert Lengyel

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One or more keywords matched the following properties of Lengyel, Ernst Robert

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overview I trained both as a scientist and as a physician and, throughout my career, I have focused on the treatment and biology of ovarian cancer (OvCa). My Ph.D. thesis was on the role of proteases in ovarian cancer and my clinical fellowship involved a special emphasis on the treatment of patients with this disease. As a surgeon and clinician, I am familiar with the presentation of ovarian cancer in patients, and experience the incredible obstacles we face in its treatment. In the laboratory, I have built the research infrastructure necessary for effective ovarian cancer research. The Lengyel lab has elucidated, at least in part, the first critical steps of ovarian cancer metastasis by paying close attention to the host microenvironment. We have collected the 25 most commonly used ovarian cancer cell lines from all over the world, including those which are chemotherapy resistant. We have established several mouse models for OvCa, and using a genetic mouse model (K-rasG12D/+/Pten-/- -- established by Dr. Tyler Jacks), a syngeneic orthotopic mouse model using mouse OvCa cells (ID8 -- established by K. Roby), and several xenograft ip models using primary and cultured human OvCa cells. I have also established a prospective OvCa tissue bank and, together with 2 gynecologic pathologists, we have assembled 13 tissue arrays including normal tissue, borderline tumor and primary tumor, & corresponding metastasis. As a surgeon, the main focus of my practice is patients with OvCa; therefore, I will be able to enroll a substantial number of patients on the proposed clinical trial and have the infrastructure in place to collect the tissue required for the translational studies. My clinical experience treating ovarian cancer, together with my laboratory, which focuses on OvCa biology, gives me a unique opportunity and obligation to find new treatments that can benefit patients with ovarian cancer.

One or more keywords matched the following items that are connected to Lengyel, Ernst Robert

Item TypeName
Concept Lymphatic Metastasis
Concept Neoplasm Metastasis
Academic Article Elevated keratin 18 protein expression indicates a favorable prognosis in patients with breast cancer.
Academic Article [The clinical importance of keratin 18 in breast cancer].
Academic Article Rac1b, a tumor associated, constitutively active Rac1 splice variant, promotes cellular transformation.
Academic Article C-Met overexpression in node-positive breast cancer identifies patients with poor clinical outcome independent of Her2/neu.
Academic Article The initial steps of ovarian cancer cell metastasis are mediated by MMP-2 cleavage of vitronectin and fibronectin.
Academic Article An orally available small-molecule inhibitor of c-Met, PF-2341066, reduces tumor burden and metastasis in a preclinical model of ovarian cancer metastasis.
Academic Article MMP-2 functions as an early response protein in ovarian cancer metastasis.
Academic Article Loss of E-cadherin promotes ovarian cancer metastasis via alpha 5-integrin, which is a therapeutic target.
Academic Article Ligand-independent activation of c-Met by fibronectin and a(5)ß(1)-integrin regulates ovarian cancer invasion and metastasis.
Academic Article Foretinib (GSK1363089), an orally available multikinase inhibitor of c-Met and VEGFR-2, blocks proliferation, induces anoikis, and impairs ovarian cancer metastasis.
Academic Article Adipocytes promote ovarian cancer metastasis and provide energy for rapid tumor growth.
Academic Article {beta}3-integrin expression on tumor cells inhibits tumor progression, reduces metastasis, and is associated with a favorable prognosis in patients with ovarian cancer.
Academic Article Targeting the urokinase plasminogen activator receptor inhibits ovarian cancer metastasis.
Academic Article Ovarian cancer development and metastasis.
Academic Article Organotypic models of metastasis: A three-dimensional culture mimicking the human peritoneum and omentum for the study of the early steps of ovarian cancer metastasis.
Academic Article Angiography-proven liver metastases explain low efficacy of lymph node dissections in medullary thyroid cancer patients.
Academic Article Mesothelial cells promote early ovarian cancer metastasis through fibronectin secretion.
Academic Article Adipose tissue and adipocytes support tumorigenesis and metastasis.
Academic Article Three-dimensional modeling of ovarian cancer.
Academic Article [Juvenile aneuploid papillary cancer of the thyroid with pulmonary metastasis].
Academic Article Microenvironment-induced downregulation of miR-193b drives ovarian cancer metastasis.
Academic Article Exosomes Promote Ovarian Cancer Cell Invasion through Transfer of CD44 to Peritoneal Mesothelial Cells.
Academic Article Genomics of Ovarian Cancer Progression Reveals Diverse Metastatic Trajectories Including Intraepithelial Metastasis to the Fallopian Tube.
Academic Article Adipocyte-induced CD36 expression drives ovarian cancer progression and metastasis.
Academic Article Fibroblasts Mobilize Tumor Cell Glycogen to Promote Proliferation and Metastasis.
Academic Article The Tumor Microenvironment Takes Center Stage in Ovarian Cancer Metastasis.
Academic Article Neutrophils facilitate ovarian cancer premetastatic niche formation in the omentum.
Academic Article Interpretation of Mismatch Repair Protein Immunohistochemistry in Endometrial Carcinoma Should Consider Both Lynch Syndrome Screening and Immunotherapy Susceptibility: An Illustrative Case Report.
Academic Article Inhibition of fascin in cancer and stromal cells blocks ovarian cancer metastasis.
Academic Article Mutant p53 regulates LPA signaling through lysophosphatidic acid phosphatase type 6.
Academic Article Proteomics reveals NNMT as a master metabolic regulator of cancer-associated fibroblasts.
Academic Article Quantitative High-Throughput Screening Using an Organotypic Model Identifies Compounds that Inhibit Ovarian Cancer Metastasis.
Academic Article Adipocyte-Induced FABP4 Expression in Ovarian Cancer Cells Promotes Metastasis and Mediates Carboplatin Resistance.
Academic Article The Natural Product ß-Escin Targets Cancer and Stromal Cells of the Tumor Microenvironment to Inhibit Ovarian Cancer Metastasis.

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  • Neoplasm Metastasis