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Lengyel, Ernst Robert

One or more keywords matched the following properties of Lengyel, Ernst Robert

Property	Value
overview	I trained both as a scientist and as a physician and, throughout my career, I have focused on the treatment and biology of ovarian cancer (OvCa). My Ph.D. thesis was on the role of proteases in ovarian cancer and my clinical fellowship involved a special emphasis on the treatment of patients with this disease. As a surgeon and clinician, I am familiar with the presentation of ovarian cancer in patients, and experience the incredible obstacles we face in its treatment. In the laboratory, I have built the research infrastructure necessary for effective ovarian cancer research. The Lengyel lab has elucidated, at least in part, the first critical steps of ovarian cancer metastasis by paying close attention to the host microenvironment. We have collected the 25 most commonly used ovarian cancer cell lines from all over the world, including those which are chemotherapy resistant. We have established several mouse models for OvCa, and using a genetic mouse model (K-rasG12D/+/Pten-/- -- established by Dr. Tyler Jacks), a syngeneic orthotopic mouse model using mouse OvCa cells (ID8 -- established by K. Roby), and several xenograft ip models using primary and cultured human OvCa cells. I have also established a prospective OvCa tissue bank and, together with 2 gynecologic pathologists, we have assembled 13 tissue arrays including normal tissue, borderline tumor and primary tumor, & corresponding metastasis. As a surgeon, the main focus of my practice is patients with OvCa; therefore, I will be able to enroll a substantial number of patients on the proposed clinical trial and have the infrastructure in place to collect the tissue required for the translational studies. My clinical experience treating ovarian cancer, together with my laboratory, which focuses on OvCa biology, gives me a unique opportunity and obligation to find new treatments that can benefit patients with ovarian cancer.

Property

Value

overview

I trained both as a scientist and as a physician and, throughout my career, I have focused on the treatment and biology of ovarian cancer (OvCa). My Ph.D. thesis was on the role of proteases in ovarian cancer and my clinical fellowship involved a special emphasis on the treatment of patients with this disease. As a surgeon and clinician, I am familiar with the presentation of ovarian cancer in patients, and experience the incredible obstacles we face in its treatment. In the laboratory, I have built the research infrastructure necessary for effective ovarian cancer research. The Lengyel lab has elucidated, at least in part, the first critical steps of ovarian cancer metastasis by paying close attention to the host microenvironment. We have collected the 25 most commonly used ovarian cancer cell lines from all over the world, including those which are chemotherapy resistant. We have established several mouse models for OvCa, and using a genetic mouse model (K-rasG12D/+/Pten-/- -- established by Dr. Tyler Jacks), a syngeneic orthotopic mouse model using mouse OvCa cells (ID8 -- established by K. Roby), and several xenograft ip models using primary and cultured human OvCa cells. I have also established a prospective OvCa tissue bank and, together with 2 gynecologic pathologists, we have assembled 13 tissue arrays including normal tissue, borderline tumor and primary tumor, & corresponding metastasis. As a surgeon, the main focus of my practice is patients with OvCa; therefore, I will be able to enroll a substantial number of patients on the proposed clinical trial and have the infrastructure in place to collect the tissue required for the translational studies. My clinical experience treating ovarian cancer, together with my laboratory, which focuses on OvCa biology, gives me a unique opportunity and obligation to find new treatments that can benefit patients with ovarian cancer.

One or more keywords matched the following items that are connected to Lengyel, Ernst Robert

Item Type	Name
Concept	Antigens, Neoplasm
Concept	Breast Neoplasms
Concept	Bone Neoplasms
Concept	Urinary Bladder Neoplasms
Concept	Fallopian Tube Neoplasms
Concept	Colonic Neoplasms
Concept	Uterine Cervical Neoplasms
Concept	Gastrointestinal Neoplasms
Concept	Genital Neoplasms, Female
Concept	DNA, Neoplasm
Concept	Colorectal Neoplasms, Hereditary Nonpolyposis
Concept	Liver Neoplasms
Concept	Neoplasm Transplantation
Concept	Neoplasm Staging
Concept	Ovarian Neoplasms
Concept	Lung Neoplasms
Concept	RNA, Neoplasm
Concept	Uterine Neoplasms
Concept	Testicular Neoplasms
Concept	Biomarkers, Tumor
Concept	Tumor Necrosis Factor-alpha
Concept	Drug Resistance, Neoplasm
Concept	Brain Stem Neoplasms
Concept	Tumor Cells, Cultured
Concept	Genes, Tumor Suppressor
Concept	Lymphocytes, Tumor-Infiltrating
Concept	Endometrial Neoplasms
Concept	Neoplasm Metastasis
Concept	Neoplasm Recurrence, Local
Concept	Neoplasms, Experimental
Concept	Peritoneal Neoplasms
Concept	Tumor Burden
Concept	Sex Cord-Gonadal Stromal Tumors
Concept	Colorectal Neoplasms
Concept	Thyroid Neoplasms
Concept	Neoplasms, Bone Tissue
Concept	Tumor Microenvironment
Concept	Cell Line, Tumor
Concept	Neoplasm Grading
Concept	Neoplasm Invasiveness
Concept	Neoplasm Proteins
Concept	Neoplasms
Concept	Neoplasms, Glandular and Epithelial
Concept	Tumor Suppressor Protein p53
Academic Article	Regulation of urokinase-type plasminogen activator expression by an ERK1-dependent signaling pathway in a squamous cell carcinoma cell line.
Academic Article	Requirement of an upstream AP-1 motif for the constitutive and phorbol ester-inducible expression of the urokinase-type plasminogen activator receptor gene.
Academic Article	In vitro modulation of human melanoma cell invasion and proliferation by all-trans-retinoic acid.
Academic Article	Elevated keratin 18 protein expression indicates a favorable prognosis in patients with breast cancer.
Academic Article	Elevated urokinase-type plasminogen activator receptor expression in a colon cancer cell line is due to a constitutively activated extracellular signal-regulated kinase-1-dependent signaling cascade.
Academic Article	Regulation of 92 kDa type IV collagenase expression by the jun aminoterminal kinase- and the extracellular signal-regulated kinase-dependent signaling cascades.
Academic Article	[The clinical importance of keratin 18 in breast cancer].
Academic Article	Integrin alpha(v)beta(3)/vitronectin interaction affects expression of the urokinase system in human ovarian cancer cells.
Academic Article	UVB increases urokinase-type plasminogen activator receptor (uPAR) expression.
Academic Article	Rac1 in human breast cancer: overexpression, mutation analysis, and characterization of a new isoform, Rac1b.
Academic Article	Increased expression of matrix metalloproteinases (MMP)-2, MMP-9, and the urokinase-type plasminogen activator is associated with progression from benign to advanced ovarian cancer.
Academic Article	Tumor-specific transcription factor binding to an activator protein-2/Sp1 element of the urokinase-type plasminogen activator receptor promoter in a first large series of resected gastrointestinal cancers.
Academic Article	Expression of latent matrix metalloproteinase 9 (MMP-9) predicts survival in advanced ovarian cancer.
Academic Article	Rac1b, a tumor associated, constitutively active Rac1 splice variant, promotes cellular transformation.
Academic Article	Dosimetric predictors of acute hematologic toxicity in cervical cancer patients treated with concurrent cisplatin and intensity-modulated pelvic radiotherapy.
Academic Article	PDGFR-alpha as a potential therapeutic target in uterine sarcomas.
Academic Article	Single-agent pulse dactinomycin has only modest activity for methotrexate-resistant gestational trophoblastic neoplasia.
Academic Article	Let-7 prevents early cancer progression by suppressing expression of the embryonic gene HMGA2.
Academic Article	C-Met overexpression in node-positive breast cancer identifies patients with poor clinical outcome independent of Her2/neu.
Academic Article	Src induces urokinase receptor gene expression and invasion/intravasation via activator protein-1/p-c-Jun in colorectal cancer.
Academic Article	Does equal treatment yield equal outcomes? The impact of race on survival in epithelial ovarian cancer.
Academic Article	Reversible posterior leukoencephalopathy syndrome following intravenous paclitaxel and intraperitoneal cisplatin chemotherapy for fallopian tube cancer.
Academic Article	Thrombin induces tumor invasion through the induction and association of matrix metalloproteinase-9 and beta1-integrin on the cell surface.
Academic Article	The initial steps of ovarian cancer cell metastasis are mediated by MMP-2 cleavage of vitronectin and fibronectin.
Academic Article	An orally available small-molecule inhibitor of c-Met, PF-2341066, reduces tumor burden and metastasis in a preclinical model of ovarian cancer metastasis.
Academic Article	MMP-2 functions as an early response protein in ovarian cancer metastasis.
Academic Article	Combination analysis of activator protein-1 family members, Sp1 and an activator protein-2alpha-related factor binding to different regions of the urokinase receptor gene in resected colorectal cancers.
Academic Article	Effects of oral contraceptives or a gonadotropin-releasing hormone agonist on ovarian carcinogenesis in genetically engineered mice.
Academic Article	CD95 promotes tumour growth.
Academic Article	c-Met overexpression is a prognostic factor in ovarian cancer and an effective target for inhibition of peritoneal dissemination and invasion.
Academic Article	A phase II, single-arm study of the anti-a5ß1 integrin antibody volociximab as monotherapy in patients with platinum-resistant advanced epithelial ovarian or primary peritoneal cancer.
Academic Article	Let-7 expression defines two differentiation stages of cancer.
Academic Article	Let-7 modulates acquired resistance of ovarian cancer to Taxanes via IMP-1-mediated stabilization of multidrug resistance 1.
Academic Article	Loss of E-cadherin promotes ovarian cancer metastasis via alpha 5-integrin, which is a therapeutic target.
Academic Article	Ligand-independent activation of c-Met by fibronectin and a(5)ß(1)-integrin regulates ovarian cancer invasion and metastasis.
Academic Article	Foretinib (GSK1363089), an orally available multikinase inhibitor of c-Met and VEGFR-2, blocks proliferation, induces anoikis, and impairs ovarian cancer metastasis.
Academic Article	FOXL2 and SOX9 distinguish the lineage of the sex cord-stromal cells in gonadoblastomas.
Academic Article	A special key for unlocking the door to targeted therapies of breast cancer.
Academic Article	The effects of 17ß-estradiol and a selective estrogen receptor modulator, bazedoxifene, on ovarian carcinogenesis.
Academic Article	Adipocytes promote ovarian cancer metastasis and provide energy for rapid tumor growth.
Academic Article	{beta}3-integrin expression on tumor cells inhibits tumor progression, reduces metastasis, and is associated with a favorable prognosis in patients with ovarian cancer.
Academic Article	Targeting the urokinase plasminogen activator receptor inhibits ovarian cancer metastasis.
Academic Article	Rethinking ovarian cancer: recommendations for improving outcomes.
Academic Article	Clinico-pathologic comparison of type II endometrial cancers based on tamoxifen exposure.
Academic Article	Involvement of a mitogen-activated protein kinase signaling pathway in the regulation of urokinase promoter activity by c-Ha-ras.
Academic Article	The first line of intra-abdominal metastatic attack: breaching the mesothelial cell layer.
Academic Article	Up-regulation of urokinase-type plasminogen activator expression by the HER2/neu proto-oncogene.
Academic Article	Tyrosine kinase mutations in human cancer.
Academic Article	Use of a novel 3D culture model to elucidate the role of mesothelial cells, fibroblasts and extra-cellular matrices on adhesion and invasion of ovarian cancer cells to the omentum.
Academic Article	The miR-200 family determines the epithelial phenotype of cancer cells by targeting the E-cadherin repressors ZEB1 and ZEB2.
Academic Article	Stimulation of urokinase expression by TNF-alpha requires the activation of binding sites for the AP-1 and PEA3 transcription factors.
Academic Article	Induction of M(r) 92,000 type IV collagenase expression in a squamous cell carcinoma cell line by fibroblasts.
Academic Article	The molecular signature of endometriosis-associated endometrioid ovarian cancer differs significantly from endometriosis-independent endometrioid ovarian cancer.
Academic Article	Ovarian cancer development and metastasis.
Academic Article	Stimulation of 92-kDa gelatinase B promoter activity by ras is mitogen-activated protein kinase kinase 1-independent and requires multiple transcription factor binding sites including closely spaced PEA3/ets and AP-1 sequences.
Academic Article	The expression of hepatocyte growth factor (HGF) and c-Met in uterine serous carcinoma.
Academic Article	HOXA9 promotes ovarian cancer growth by stimulating cancer-associated fibroblasts.
Academic Article	Differential expression of c-Met, its ligand HGF/SF and HER2/neu in DCIS and adjacent normal breast tissue.
Academic Article	A novel multipurpose monoclonal antibody for evaluating human c-Met expression in preclinical and clinical settings.
Academic Article	Up-regulation of alpha5-integrin by E-cadherin loss in hypoxia and its key role in the migration of extravillous trophoblast cells during early implantation.
Academic Article	Rac1 and Rho contribute to the migratory and invasive phenotype associated with somatic E-cadherin mutation.
Academic Article	Organotypic models of metastasis: A three-dimensional culture mimicking the human peritoneum and omentum for the study of the early steps of ovarian cancer metastasis.
Academic Article	Relationship of type II diabetes and metformin use to ovarian cancer progression, survival, and chemosensitivity.
Academic Article	Angiography-proven liver metastases explain low efficacy of lymph node dissections in medullary thyroid cancer patients.
Academic Article	miR-92a inhibits peritoneal dissemination of ovarian cancer cells by inhibiting integrin a5 expression.
Academic Article	Serial sectioning of the fallopian tube allows for improved identification of primary fallopian tube carcinoma.
Academic Article	MicroRNAs reprogram normal fibroblasts into cancer-associated fibroblasts in ovarian cancer.
Academic Article	Mesothelial cells promote early ovarian cancer metastasis through fibronectin secretion.
Academic Article	Expression of the homeobox gene HOXA9 in ovarian cancer induces peritoneal macrophages to acquire an M2 tumor-promoting phenotype.
Academic Article	Adipose tissue and adipocytes support tumorigenesis and metastasis.
Academic Article	Utility of routine surveillance methods in detecting recurrence in high grade endometrial cancer patients.
Academic Article	Three-dimensional modeling of ovarian cancer.
Academic Article	Urokinase plasminogen activator system-targeted delivery of nanobins as a novel ovarian cancer therapy.
Academic Article	Epithelial ovarian cancer experimental models.
Academic Article	WNT7A/ß-catenin signaling induces FGF1 and influences sensitivity to niclosamide in ovarian cancer.
Academic Article	Statin therapy is associated with improved survival in patients with non-serous-papillary epithelial ovarian cancer: a retrospective cohort analysis.
Academic Article	Summary of the 2013 American Association for Cancer Research (AACR) Annual Meeting.
Academic Article	Old drug, new trick: repurposing metformin for gynecologic cancers?
Academic Article	Metformin inhibits ovarian cancer growth and increases sensitivity to paclitaxel in mouse models.
Academic Article	Molecular pathways: trafficking of metabolic resources in the tumor microenvironment.
Academic Article	[Juvenile aneuploid papillary cancer of the thyroid with pulmonary metastasis].
Academic Article	Quantitative high throughput screening using a primary human three-dimensional organotypic culture predicts in vivo efficacy.
Academic Article	Whole-genome characterization of chemoresistant ovarian cancer.
Academic Article	Patterns and utility of routine surveillance in high grade endometrial cancer.
Academic Article	The hypoxia-related microRNA miR-199a-3p displays tumor suppressor functions in ovarian carcinoma.
Academic Article	Glucocorticoid receptor activation inhibits chemotherapy-induced cell death in high-grade serous ovarian carcinoma.
Academic Article	Hyperglycemia-induced metabolic compensation inhibits metformin sensitivity in ovarian cancer.
Academic Article	Rethinking ovarian cancer II: reducing mortality from high-grade serous ovarian cancer.
Academic Article	MicroRNAs as mediators and communicators between cancer cells and the tumor microenvironment.
Academic Article	Microenvironment-induced downregulation of miR-193b drives ovarian cancer metastasis.
Academic Article	Corrigendum: Whole-genome characterization of chemoresistant ovarian cancer.
Academic Article	Modeling the Early Steps of Ovarian Cancer Dissemination in an Organotypic Culture of the Human Peritoneal Cavity.
Academic Article	A prospective study evaluating diffusion weighted magnetic resonance imaging (DW-MRI) in the detection of peritoneal carcinomatosis in suspected gynecologic malignancies.
Academic Article	Integrative proteomic profiling of ovarian cancer cell lines reveals precursor cell associated proteins and functional status.
Academic Article	Metformin Targets Central Carbon Metabolism and Reveals Mitochondrial Requirements in Human Cancers.
Academic Article	Exosomes Promote Ovarian Cancer Cell Invasion through Transfer of CD44 to Peritoneal Mesothelial Cells.
Academic Article	Reversal of Chemoresistance in Ovarian Cancer by Co-Delivery of a P-Glycoprotein Inhibitor and Paclitaxel in a Liposomal Platform.
Academic Article	Genomics of Ovarian Cancer Progression Reveals Diverse Metastatic Trajectories Including Intraepithelial Metastasis to the Fallopian Tube.
Academic Article	Ovarian cancer treatment in black and white women: A comparison of clinico-pathologic factors and outcome.
Academic Article	Prolactin Receptor-Mediated Internalization of Imaging Agents Detects Epithelial Ovarian Cancer with Enhanced Sensitivity and Specificity.
Academic Article	Unsaturated Fatty Acids Maintain Cancer Cell Stemness.
Academic Article	Loss of BRCA1 in the Cells of Origin of Ovarian Cancer Induces Glycolysis: A Window of Opportunity for Ovarian Cancer Chemoprevention.
Academic Article	A High-Throughput Screening Model of the Tumor Microenvironment for Ovarian Cancer Cell Growth.
Academic Article	High glucocorticoid receptor expression predicts short progression-free survival in ovarian cancer.
Academic Article	Multi-level Proteomics Identifies CT45 as a Chemosensitivity Mediator and Immunotherapy Target in Ovarian Cancer.
Academic Article	Induction of Neoantigen-Specific Cytotoxic T Cells and Construction of T-cell Receptor-Engineered T Cells for Ovarian Cancer.
Academic Article	A 3D tumor microenvironment regulates cell proliferation, peritoneal growth and expression patterns.
Academic Article	An activity-dependent proximity ligation platform for spatially resolved quantification of active enzymes in single cells.
Academic Article	Who are the long-term survivors of high grade serous ovarian cancer?
Academic Article	Adipocyte-induced CD36 expression drives ovarian cancer progression and metastasis.
Academic Article	m6A mRNA methylation regulates AKT activity to promote the proliferation and tumorigenicity of endometrial cancer.
Academic Article	The road to long-term survival: Surgical approach and longitudinal treatments of long-term survivors of advanced-stage serous ovarian cancer.
Academic Article	Fibroblasts Mobilize Tumor Cell Glycogen to Promote Proliferation and Metastasis.
Academic Article	Cancer as a Matter of Fat: The Crosstalk between Adipose Tissue and Tumors.
Academic Article	The Tumor Microenvironment Takes Center Stage in Ovarian Cancer Metastasis.
Academic Article	Neutrophils facilitate ovarian cancer premetastatic niche formation in the omentum.
Academic Article	SPHK1 Is a Novel Target of Metformin in Ovarian Cancer.
Academic Article	Interpretation of Mismatch Repair Protein Immunohistochemistry in Endometrial Carcinoma Should Consider Both Lynch Syndrome Screening and Immunotherapy Susceptibility: An Illustrative Case Report.
Academic Article	Critical questions in ovarian cancer research and treatment: Report of an American Association for Cancer Research Special Conference.
Academic Article	Inhibition of fascin in cancer and stromal cells blocks ovarian cancer metastasis.
Academic Article	Mutant p53 regulates LPA signaling through lysophosphatidic acid phosphatase type 6.
Academic Article	Proteomics reveals NNMT as a master metabolic regulator of cancer-associated fibroblasts.
Academic Article	New Roles for Glycogen in Tumor Progression.
Academic Article	Quantitative High-Throughput Screening Using an Organotypic Model Identifies Compounds that Inhibit Ovarian Cancer Metastasis.
Academic Article	Ultrasensitive, multiplexed chemoproteomic profiling with soluble activity-dependent proximity ligation.
Academic Article	Cancer-derived small extracellular vesicles promote angiogenesis by heparin-bound, bevacizumab-insensitive VEGF, independent of vesicle uptake.
Academic Article	Mesothelial Cell HIF1a Expression Is Metabolically Downregulated by Metformin to Prevent Oncogenic Tumor-Stromal Crosstalk.
Academic Article	Cancer-derived small extracellular vesicles promote angiogenesis by heparin-bound, bevacizumab-insensitive VEGF, independent of vesicle uptake.
Academic Article	Adipocyte-Induced FABP4 Expression in Ovarian Cancer Cells Promotes Metastasis and Mediates Carboplatin Resistance.
Academic Article	A streamlined mass spectrometry-based proteomics workflow for large-scale FFPE tissue analysis.
Academic Article	Are We Ready for Hyperthermic Intraperitoneal Chemotherapy in the Upfront Treatment of Ovarian Cancer?
Academic Article	Deconstructing tumor heterogeneity: the stromal perspective.
Academic Article	Complete Response in a Patient With Chemorefractory EGFR-Amplified, PD-L1-Positive Metastatic Gastric Cancer Treated By Dual Anti-EGFR and Anti-PD-1 Monoclonal Antibody Therapy.
Academic Article	Updates and New Options in Advanced Epithelial Ovarian Cancer Treatment.
Academic Article	Neutrophil elastase selectively kills cancer cells and attenuates tumorigenesis.
Academic Article	The Ratio of Toxic-to-Nontoxic miRNAs Predicts Platinum Sensitivity in Ovarian Cancer.
Academic Article	The Effects of Chemotherapeutics on the Ovarian Cancer Microenvironment.
Academic Article	The Natural Product ß-Escin Targets Cancer and Stromal Cells of the Tumor Microenvironment to Inhibit Ovarian Cancer Metastasis.
Academic Article	Germline mutations in Black patients with ovarian, fallopian tube and primary peritoneal carcinomas.
Academic Article	Neoadjuvant Chemotherapy Induces Genomic and Transcriptomic Changes in Ovarian Cancer.
Academic Article	Resilience in the Face of Pandemic: The Impact of COVID-19 on the Psychologic Morbidity and Health-Related Quality of Life Among Women With Ovarian Cancer.
Academic Article	The adipocyte microenvironment and cancer.
Academic Article	Molecular Characterizations of Gynecologic Carcinosarcomas: A Focus on the Immune Microenvironment.
Academic Article	Ovarian Masses: The Value of Acoustic Shadowing on Ultrasound Examination.
Academic Article	Cancer-associated mesothelial cell-derived ANGPTL4 and STC1 promote the early steps of ovarian cancer metastasis.
Concept	Cancer-Associated Fibroblasts
Concept	Cancer Survivors
Academic Article	Understanding Long-Term Survival of Patients with Ovarian Cancer-The Tumor Microenvironment Comes to the Forefront.
Academic Article	The glycoprotein CD147 defines miRNA-enriched extracellular vesicles that derive from cancer cells.
Academic Article	Decoding evolutionary trajectories of ovarian cancer metastasis.
Academic Article	Diagnostic Performance of Ultrasonography-Based Risk Models in Differentiating Between Benign and Malignant Ovarian Tumors in a US Cohort.
Academic Article	Adipocytes reprogram cancer cell metabolism by diverting glucose towards glycerol-3-phosphate thereby promoting metastasis.
Academic Article	Spatial proteo-transcriptomic profiling reveals the molecular landscape of borderline ovarian tumors and their invasive progression.
Academic Article	5-Hydroxymethylcytosine signals in serum are a predictor of chemoresistance in high-grade serous ovarian cancer.

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Neoplasms