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Search Results to Michelle M. Lebeau

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overview Dr. Le Beau’s research focuses on the molecular analysis of the recurring chromosomal abnormalities in human leukemias and lymphomas, correlating specific abnormalities with morphological and clinical features and the development of risk-adapted therapy. Ongoing projects include the molecular cloning of haploinsufficient myeloid leukemia-related genes involved in the del(5q) characteristic of therapy-related acute myeloid leukemia; development and characterization of murine models recapitulating the genetic mutations in acute myeloid leukemia and identification of secondary, cooperating mutations and genetic pathways to leukemogenesis; and the application of murine models for pre-clinical drug testing.

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Concept Cloning, Molecular
Academic Article pMCT108.2 is a chimaeric clone which physically maps to human chromosome bands 9q33 (D9S203) and 18q21.1 (D18S24).
Academic Article Analysis of the t(6;11)(q27;q23) in leukemia shows a consistent breakpoint in AF6 in three patients and in the ML-2 cell line.
Academic Article Cloning and chromosomal localization of a novel gene-encoding a human beta 2-integrin alpha subunit.
Academic Article Cloning and characterization of MST4, a novel Ste20-like kinase.
Academic Article A human Hox 1 homeobox gene exhibits myeloid-specific expression of alternative transcripts in human hematopoietic cells.
Academic Article Molecular cloning of the breakpoints of a complex Philadelphia chromosome translocation: identification of a repeated region on chromosome 17.
Academic Article Molecular analysis of a t(11;14)(q23;q11) from a patient with null-cell acute lymphoblastic leukemia.
Academic Article Molecular characterization of 16p deletions associated with inversion 16 defines the critical fusion for leukemogenesis.
Academic Article Structural organization and mapping of the human mitochondrial glycerol phosphate dehydrogenase-encoding gene and pseudogene.
Academic Article Identification and analysis of the gene encoding human PC2, a prohormone convertase expressed in neuroendocrine tissues.
Academic Article Identification of a gene, MLL, that spans the breakpoint in 11q23 translocations associated with human leukemias.

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