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Cutting edge: the NK cell receptor 2B4 augments antigen-specific T cell cytotoxicity through CD48 ligation on neighboring T cells.
Requirement of homotypic NK-cell interactions through 2B4(CD244)/CD48 in the generation of NK effector functions.
2B4 (CD244)-CD48 interactions provide a novel MHC class I-independent system for NK-cell self-tolerance in mice.
2B4 (CD244) is a non-MHC binding receptor with multiple functions on natural killer cells and CD8+ T cells.
2B4 inhibits NK-cell fratricide.