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Search Results to Sara Szuchet

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One or more keywords matched the following properties of Szuchet, Sara

keywords Myelin Sheath
overview The long-term goal of my laboratory is to decipher the etiology and pathogenesis of multiple sclerosis (MS) – a CNS demyelinating and neurodegenerative disease that cripples the young and bright. With the firm belief that in order to decrypt the breakdown of myelin in MS, we have to understand how it is formed, our current efforts are centered on two major projects. One, defining the molecular mechanism of myelin sheath formation by following the synthesis of myelin membranes (MyMs), their packaging into myelinophore organelles (MFOs) and transportation along an oligodendrocyte process using live imaging of embryonic avian optic nerve at different stages of development; purifying and characterizing the contents of MFOs. Two, testing the hypothesis that ectosomes are the conveyors of signals that coordinate and orchestrate the modular structure of the myelinated axon. We are developing technologies to obtain pure cell-specific ectosomes by molecularly color-code them. We are also customizing a microfluidic platform suitable to integrate multiple processes in a single lab-on-a-chip format. We plan to establish unique EM grid compatible bi-chamber for OLG-neuron cultures and capture the formation of cell-specific ectosomes using correlative light and electron microscopy and phase contrast cryo-electron tomography. We will assemble tomograms of the initial OLG-neuron encounter so that we can structurally model the interface in a 3D space.

One or more keywords matched the following items that are connected to Szuchet, Sara

Item TypeName
Concept Myelin Proteins
Concept Myelin Proteolipid Protein
Concept Myelin-Associated Glycoprotein
Academic Article Myelination by mature ovine oligodendrocytes in vivo and in vitro: evidence that different steps in the myelination process are independently controlled.
Academic Article Oligodendrocyte proteoglycans: modulation by cell-substratum adhesion.
Academic Article Oligodendrocytes express an alpha/beta-interferon-susceptible Mx gene: molecular characterization of the encoded protein.
Academic Article Oligodendrocyte transmembrane protein: a novel member of the glutamate-binding protein subfamily.
Academic Article Intracellular messengers. Influence of oligodendrocyte substratum adhesion.
Academic Article Mature oligodendrocytes cultured in the absence of neurons recapitulate the ontogenic development of myelin membranes.
Academic Article Expression and modulation of K+ currents in oligodendrocytes: possible role in myelinogenesis.
Academic Article The genetic signature of perineuronal oligodendrocytes reveals their unique phenotype.
Academic Article Oligodendrocyte adhesion activates protein kinase C-mediated phosphorylation of myelin basic protein.
Academic Article Plasma membrane of cultured oligodendrocytes: III. Relatedness to myelin.
Academic Article Functional implications for the microtubule-associated protein tau: localization in oligodendrocytes.
Academic Article Myelin palingenesis. 2. Immunocytochemical localization of myelin/oligodendrocyte glycolipids in multilamellar structures.
Academic Article Lipid metabolism of isolated oligodendrocytes maintained in long-term culture mimics events associated with myelinogenesis.
Academic Article An in-vitro approach to the study of oligodendrocytes and their involvement in multiple sclerosis.
Academic Article Characterization of a subset of oligodendrocytes separated on the basis of selective adherence properties.
Academic Article Synthesis of myelin glycosphingolipids by isolated oligodendrocytes in tissue culture.
Academic Article Ultrastructural changes accompanying the growth of isolated oligodendrocytes.
Academic Article Depolarizing agents and tumor necrosis factor-alpha modulate protein phosphorylation in oligodendrocytes.
Academic Article Oligodendrocyte substratum adhesion modulates expression of adenylate cyclase-linked receptors.
Academic Article A monoclonal antibody that binds to both astrocytes and myelin sheaths.
Academic Article Myelin palingenesis. 1. Electron microscopical localization of myelin/oligodendrocyte proteins in multilamellar structures by the immunogold method.
Academic Article Phosphorylation of myelin basic protein in intact oligodendrocytes: inhibition by galactosylsphingosine and cyclic AMP.
Academic Article A peanut agglutinin binding glycoprotein in CNS myelin and oligodendrocytes.
Academic Article CNS myelin sheath is stochastically built by homotypic fusion of myelin membranes within the bounds of an oligodendrocyte process.

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