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Insulin-like growth factor-1 lowers spreading depression susceptibility and reduces oxidative stress.
Insulin-like growth factor-1 abrogates microglial oxidative stress and TNF-a responses to spreading depression.
IFN?-stimulated dendritic cell exosomes as a potential therapeutic for remyelination.
Spreading depression requires microglia and is decreased by their M2a polarization from environmental enrichment.
Phasic Treatment with Interferon Gamma Stimulates Release of Exosomes that Protect Against Spreading Depression.
Environmental Enrichment Stimulates Immune Cell Secretion of Exosomes that Promote CNS Myelination and May Regulate Inflammation.
Insulin-like growth factor-1 inhibits spreading depression-induced trigeminal calcitonin gene related peptide, oxidative stress & neuronal activation in rat.
Insulin-like growth factor-1 inhibits nitroglycerin-induced trigeminal activation of oxidative stress, calcitonin gene-related peptide and c-Fos expression.
Environment Enrichment, Neuroprotection and Spreading Depression
Development of Nasal IGF-1 as a Migraine Therapeutic