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Enoyl-(Acyl-Carrier-Protein) Reductase (NADH)
Expression, purification and crystallization of the Plasmodium falciparum enoyl reductase.
Delivery of antimicrobials into parasites.
Triclosan inhibits the growth of Plasmodium falciparum and Toxoplasma gondii by inhibition of apicomplexan Fab I.
Expression, purification and preliminary crystallographic analysis of the Toxoplasma gondii enoyl reductase.
Studies of Toxoplasma gondii and Plasmodium falciparum enoyl acyl carrier protein reductase and implications for the development of antiparasitic agents.
Design, synthesis, and biological activity of diaryl ether inhibitors of Toxoplasma gondii enoyl reductase.
Modification of triclosan scaffold in search of improved inhibitors for enoyl-acyl carrier protein (ACP) reductase in Toxoplasma gondii.
Development of a triclosan scaffold which allows for adaptations on both the A- and B-ring for transport peptides.
The benzimidazole based drugs show good activity against T. gondii but poor activity against its proposed enoyl reductase enzyme target.
Discrimination of potent inhibitors of Toxoplasma gondii enoyl-acyl carrier protein reductase by a thermal shift assay.
Identification and development of novel inhibitors of Toxoplasma gondii enoyl reductase.