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Gupta, Mahesh P.
One or more keywords matched the following items that are connected to Gupta, Mahesh P.
Item TypeName
Concept Myocytes, Cardiac
Academic Article Single-stranded DNA-binding proteins PURalpha and PURbeta bind to a purine-rich negative regulatory element of the alpha-myosin heavy chain gene and control transcriptional and translational regulation of the gene expression. Implications in the repression of alpha-myosin heavy chain during heart failure.
Academic Article Increased expression of poly(ADP-ribose) polymerase-1 contributes to caspase-independent myocyte cell death during heart failure.
Academic Article Poly(ADP-ribose) polymerase-1-dependent cardiac myocyte cell death during heart failure is mediated by NAD+ depletion and reduced Sir2alpha deacetylase activity.
Academic Article Concurrent opposite effects of trichostatin A, an inhibitor of histone deacetylases, on expression of alpha-MHC and cardiac tubulins: implication for gain in cardiac muscle contractility.
Academic Article HDAC4 and PCAF bind to cardiac sarcomeres and play a role in regulating myofilament contractile activity.
Academic Article The single-strand DNA/RNA-binding protein, Purbeta, regulates serum response factor (SRF)-mediated cardiac muscle gene expression.
Academic Article SIRT3 is a stress-responsive deacetylase in cardiomyocytes that protects cells from stress-mediated cell death by deacetylation of Ku70.
Academic Article SIRT1 promotes cell survival under stress by deacetylation-dependent deactivation of poly(ADP-ribose) polymerase 1.
Academic Article Pathogenic properties of the N-terminal region of cardiac myosin binding protein-C in vitro.
Academic Article A novel cardiomyocyte-enriched microRNA, miR-378, targets insulin-like growth factor 1 receptor: implications in postnatal cardiac remodeling and cell survival.
Academic Article Emerging roles of SIRT1 deacetylase in regulating cardiomyocyte survival and hypertrophy.
Academic Article Acetylation of a conserved lysine residue in the ATP binding pocket of p38 augments its kinase activity during hypertrophy of cardiomyocytes.
Academic Article Nampt secreted from cardiomyocytes promotes development of cardiac hypertrophy and adverse ventricular remodeling.
Academic Article Deficiency of cardiomyocyte-specific microRNA-378 contributes to the development of cardiac fibrosis involving a transforming growth factor ß (TGFß1)-dependent paracrine mechanism.
Academic Article SIRT3 deacetylates and activates OPA1 to regulate mitochondrial dynamics during stress.
Academic Article Honokiol blocks and reverses cardiac hypertrophy in mice by activating mitochondrial Sirt3.
Academic Article Sirt3 protects mitochondrial DNA damage and blocks the development of doxorubicin-induced cardiomyopathy in mice.
Academic Article Deficiency of cardiomyocyte-specific microRNA-378 contributes to the development of cardiac fibrosis involving a transforming growth factor ß (TGFß1)-dependent paracrine mechanism.
Academic Article Honokiol, an activator of Sirtuin-3 (SIRT3) preserves mitochondria and protects the heart from doxorubicin-induced cardiomyopathy in mice.
Grant Histone deacetylases in pathogenesis of heart failure
Grant Activation of sirtuins to prevent adverse cardiac remodeling after CABG
Grant Improving post-surgery recovery of failing hearts by targeting cardiomyocyte senescence
Grant The Role of PARP-SIR2 Signaling in Heart Failure
Grant Blocking cardiac toxicity of anticancer drugs
Academic Article The nuclear and mitochondrial sirtuins, Sirt6 and Sirt3, regulate each other's activity and protect the heart from developing obesity-mediated diabetic cardiomyopathy.
Academic Article The nuclear sirtuin SIRT6 protects the heart from developing aging-associated myocyte senescence and cardiac hypertrophy.
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  • Myocytes Cardiac