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Search Results to Albert Bendelac

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One or more keywords matched the following properties of Bendelac, Albert

PropertyValue
keywords B cells
keywords Innate lymphocytes
keywords T cells
keywords NKT cells
keywords Intestinal IgA B cells
keywords Intestinal intraepithelial T cells
overview Innate and Innate-Like Lymphocytes Our laboratory studies the populations of lymphocytes that reside at mucosal barriers and perform rapid innate-like functions to maintain homeostasis and protect against infection, injury and tumor. We use developmental biology and genetic engineering to define the identity and track the function of multiple ‘unconventional’ populations including NKT cells, MAIT cells, gamma-delta T cells, innate lymphoid cells, intraepithelial intestinal T lymphocytes and IgA producing intestinal B cells. Ultimately, these studies help identify the central relationships between immunity and microbiome at the intestinal barrier.

One or more keywords matched the following items that are connected to Bendelac, Albert

Item TypeName
Concept Antigen-Presenting Cells
Concept Bone Marrow Cells
Concept Antigens, Differentiation, B-Lymphocyte
Concept B-Lymphocytes
Concept Clone Cells
Concept Dendritic Cells
Concept Epithelial Cells
Concept Killer Cells, Natural
Concept T-Lymphocytes, Helper-Inducer
Concept Hematopoietic Stem Cells
Concept HeLa Cells
Concept Plasma Cells
Concept Receptors, Antigen, B-Cell
Concept Stem Cells
Concept CHO Cells
Concept Th1 Cells
Concept Tumor Cells, Cultured
Concept B-Lymphocyte Subsets
Concept CD4-Positive T-Lymphocytes
Concept CD8-Positive T-Lymphocytes
Concept Th2 Cells
Concept Precursor Cells, T-Lymphoid
Concept Jurkat Cells
Concept Natural Killer T-Cells
Concept T-Lymphocytes, Cytotoxic
Concept Lymphoma, B-Cell
Concept Stromal Cells
Concept T-Lymphocytes, Regulatory
Concept Lymphoid Progenitor Cells
Concept Cells, Cultured
Concept Lymphocytes
Concept T-Lymphocytes
Academic Article Multiple defects in antigen presentation and T cell development by mice expressing cytoplasmic tail-truncated CD1d.
Academic Article Distinct functional lineages of human V(alpha)24 natural killer T cells.
Academic Article Synthesis and NKT cell stimulating properties of fluorophore- and biotin-appended 6"-amino-6"-deoxy-galactosylceramides.
Academic Article Murine cytomegalovirus m02 gene family protects against natural killer cell-mediated immune surveillance.
Academic Article The contribution of NKT cells, NK cells, and other gamma-chain-dependent non-T non-B cells to IL-12-mediated rejection of tumors.
Academic Article Glycosylphosphatidylinositol-anchored mucin-like glycoproteins from Trypanosoma cruzi bind to CD1d but do not elicit dominant innate or adaptive immune responses via the CD1d/NKT cell pathway.
Academic Article Analysis of in situ NK cell responses during viral infection.
Academic Article A thymic precursor to the NK T cell lineage.
Academic Article Lipid presentation by CD1: the short and the long lipid story.
Academic Article Adjuvants of immunity: harnessing innate immunity to promote adaptive immunity.
Academic Article The paradox of immune molecular recognition of alpha-galactosylceramide: low affinity, low specificity for CD1d, high affinity for alpha beta TCRs.
Academic Article T cell development in mice expressing CD1d directed by a classical MHC class II promoter.
Academic Article Testing the NKT cell hypothesis of human IDDM pathogenesis.
Academic Article Thymocyte expression of cathepsin L is essential for NKT cell development.
Academic Article Mechanisms governing B cell developmental defects in invariant chain-deficient mice.
Academic Article Effects of lipid chain lengths in alpha-galactosylceramides on cytokine release by natural killer T cells.
Academic Article The role of innate immunity in autoimmunity.
Academic Article Exogenous and endogenous glycolipid antigens activate NKT cells during microbial infections.
Academic Article Lysosomal glycosphingolipid recognition by NKT cells.
Academic Article Mechanisms imposing the Vbeta bias of Valpha14 natural killer T cells and consequences for microbial glycolipid recognition.
Academic Article Signaling for NKT cell development: the SAP-FynT connection.
Academic Article Genetic evidence supporting selection of the Valpha14i NKT cell lineage from double-positive thymocyte precursors.
Academic Article Expansion and long-range differentiation of the NKT cell lineage in mice expressing CD1d exclusively on cortical thymocytes.
Academic Article Characterization of the early stages of thymic NKT cell development.
Academic Article Prevention of type 1 diabetes by invariant NKT cells is independent of peripheral CD1d expression.
Academic Article A modified alpha-galactosyl ceramide for staining and stimulating natural killer T cells.
Academic Article Sensitive detection of isoglobo and globo series tetraglycosylceramides in human thymus by ion trap mass spectrometry.
Academic Article The Niemann-Pick type C2 protein loads isoglobotrihexosylceramide onto CD1d molecules and contributes to the thymic selection of NKT cells.
Academic Article Nondeletional pathways for the development of autoreactive thymocytes.
Academic Article Liver autoimmunity triggered by microbial activation of natural killer T cells.
Academic Article Synthesis and evaluation of stimulatory properties of Sphingomonadaceae glycolipids.
Academic Article Alpha anomers of iGb3 and Gb3 stimulate cytokine production by natural killer T cells.
Academic Article Synthesis of diglycosylceramides and evaluation of their iNKT cell stimulatory properties.
Academic Article TCR-inducible PLZF transcription factor required for innate phenotype of a subset of gammadelta T cells with restricted TCR diversity.
Academic Article Inhibitor of DNA binding 3 limits development of murine slam-associated adaptor protein-dependent "innate" gammadelta T cells.
Academic Article A distal effect of microsomal triglyceride transfer protein deficiency on the lysosomal recycling of CD1d.
Academic Article Glycolipids for natural killer T cells.
Academic Article The sequential activity of Gata3 and Thpok is required for the differentiation of CD1d-restricted CD4+ NKT cells.
Academic Article S1P1 receptor expression regulates emergence of NKT cells in peripheral tissues.
Academic Article A naive-like population of human CD1d-restricted T cells expressing intermediate levels of promyelocytic leukemia zinc finger.
Academic Article B-cells and IL-4 promote methylcholanthrene-induced carcinogenesis but there is no evidence for a role of T/NKT-cells and their effector molecules (Fas-ligand, TNF-a, perforin).
Academic Article Impact of sugar stereochemistry on natural killer T cell stimulation by bacterial glycolipids.
Academic Article Airborne lipid antigens mobilize resident intravascular NKT cells to induce allergic airway inflammation.
Academic Article Scavenger receptors target glycolipids for natural killer T cell activation.
Academic Article BTB-ZF factors recruit the E3 ligase cullin 3 to regulate lymphoid effector programs.
Academic Article Lysosomal recycling terminates CD1d-mediated presentation of short and polyunsaturated variants of the NKT cell lipid antigen alphaGalCer.
Academic Article Fatty acid amide hydrolase shapes NKT cell responses by influencing the serum transport of lipid antigen in mice.
Academic Article Cutting edge: impaired glycosphingolipid trafficking and NKT cell development in mice lacking Niemann-Pick type C1 protein.
Academic Article Distinct APCs explain the cytokine bias of a-galactosylceramide variants in vivo.
Academic Article SAP protein-dependent natural killer T-like cells regulate the development of CD8(+) T cells with innate lymphocyte characteristics.
Academic Article Sensitivity of NK1.1-negative NKT cells to transgenic BATF defines a role for activator protein-1 in the expansion and maturation of immature NKT cells in the thymus.
Academic Article Homotypic interactions mediated by Slamf1 and Slamf6 receptors control NKT cell lineage development.
Academic Article Promyelocytic leukemia zinc finger turns on the effector T cell program without requirement for agonist TCR signaling.
Academic Article Elevated and sustained expression of the transcription factors Egr1 and Egr2 controls NKT lineage differentiation in response to TCR signaling.
Academic Article Selection and expansion of CD8alpha/alpha(1) T cell receptor alpha/beta(1) intestinal intraepithelial lymphocytes in the absence of both classical major histocompatibility complex class I and nonclassical CD1 molecules.
Academic Article Editing of CD1d-bound lipid antigens by endosomal lipid transfer proteins.
Academic Article Structure and function of a potent agonist for the semi-invariant natural killer T cell receptor.
Academic Article The biology of NKT cells.
Academic Article Crystal structures of mouse CD1d-iGb3 complex and its cognate Valpha14 T cell receptor suggest a model for dual recognition of foreign and self glycolipids.
Academic Article The transcription factor PLZF directs the effector program of the NKT cell lineage.
Academic Article Intrathymic proliferation wave essential for Valpha14+ natural killer T cell development depends on c-Myc.
Academic Article PLZF induces an intravascular surveillance program mediated by long-lived LFA-1-ICAM-1 interactions.
Academic Article The majority of CD1d-sulfatide-specific T cells in human blood use a semiinvariant Vd1 TCR.
Academic Article Transcriptional regulation of the NKT cell lineage.
Academic Article Egr2-dependent gene expression profiling and ChIP-Seq reveal novel biologic targets in T cell anergy.
Academic Article Crystal structure of Vd1 T cell receptor in complex with CD1d-sulfatide shows MHC-like recognition of a self-lipid by human ?d T cells.
Academic Article A committed precursor to innate lymphoid cells.
Academic Article Elevated T cell receptor signaling identifies a thymic precursor to the TCRaß(+)CD4(-)CD8ß(-) intraepithelial lymphocyte lineage.
Academic Article Efficacy of ABX196, a new NKT agonist, in prophylactic human vaccination.
Academic Article The identification of the endogenous ligands of natural killer T cells reveals the presence of mammalian a-linked glycosylceramides.
Academic Article Natural killer T (NKT)-B-cell interactions promote prolonged antibody responses and long-term memory to pneumococcal capsular polysaccharides.
Academic Article Stimulation of natural killer T cells by glycolipids.
Academic Article A negative feedback loop mediated by the Bcl6-cullin 3 complex limits Tfh cell differentiation.
Academic Article PLZF expression maps the early stages of ILC1 lineage development.
Academic Article Polarized effector programs for innate-like thymocytes.
Academic Article Innate and Adaptive Humoral Responses Coat Distinct Commensal Bacteria with Immunoglobulin A.
Academic Article Endogenous ligands of natural killer T cells are alpha-linked glycosylceramides.
Academic Article Intrinsic functional defects of type 2 innate lymphoid cells impair innate allergic inflammation in promyelocytic leukemia zinc finger (PLZF)-deficient mice.
Academic Article Single-cell analysis defines the divergence between the innate lymphoid cell lineage and lymphoid tissue-inducer cell lineage.
Academic Article The Innate Lymphoid Cell Precursor.
Academic Article Multiple layers of transcriptional regulation by PLZF in NKT-cell development.
Academic Article NKT cells contribute to basal IL-4 production but are not required to induce experimental asthma.
Academic Article A shared Runx1-bound Zbtb16 enhancer directs innate and innate-like lymphoid lineage development.
Academic Article Natural polyreactive IgA antibodies coat the intestinal microbiota.
Academic Article IgA Responses to Microbiota.
Academic Article Diverse developmental pathways of intestinal intraepithelial lymphocytes.
Academic Article Autoreactivity by design: innate B and T lymphocytes.
Academic Article CD1d endosomal trafficking is independently regulated by an intrinsic CD1d-encoded tyrosine motif and by the invariant chain.
Academic Article The mouse CD1d-restricted repertoire is dominated by a few autoreactive T cell receptor families.
Academic Article Distinct subsets of CD1d-restricted T cells recognize self-antigens loaded in different cellular compartments.
Academic Article Innate and adaptive functions of the CD1 pathway of antigen presentation.
Academic Article Positive selection of mouse NK1+ T cells by CD1-expressing cortical thymocytes.
Academic Article CD1-restricted T-cell responses and microbial infection.
Academic Article Increased interleukin 4 and immunoglobulin E production in transgenic mice overexpressing NK1 T cells.
Academic Article Unaltered phenotype, tissue distribution and function of Valpha14(+) NKT cells in germ-free mice.
Academic Article Tissue-specific recognition of mouse CD1 molecules.
Academic Article CD1.1 expression by mouse antigen-presenting cells and marginal zone B cells.
Academic Article Mouse CD1-specific NK1 T cells: development, specificity, and function.
Academic Article In vivo identification of glycolipid antigen-specific T cells using fluorescent CD1d tetramers.
Academic Article An invariant T cell receptor alpha chain defines a novel TAP-independent major histocompatibility complex class Ib-restricted alpha/beta T cell subpopulation in mammals.
Academic Article Cutting edge: Cross-talk between cells of the innate immune system: NKT cells rapidly activate NK cells.
Academic Article CD1 recognition by mouse NK1+ T lymphocytes.
Academic Article An invariant T cell receptor alpha chain is used by a unique subset of major histocompatibility complex class I-specific CD4+ and CD4-8- T cells in mice and humans.
Academic Article B cell superantigens in the human intestinal microbiota.
Academic Article Multi-transcription factor reporter mice delineate early precursors to the ILC and LTi lineages.
Academic Article A Gata3 enhancer necessary for ILC2 development and function.
Academic Article The molecular characterization of antibody binding to a superantigen-like protein from a commensal microbe.

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