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One or more keywords matched the following properties of Adams, Erin J.
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overview Our laboratory is interested in the molecular signals that are used by the immune system to distinguish healthy from unhealthy tissue. Many of our projects focus on “unconventional” T cell recognition, involving ?d T cells, Natural Killer T cells and Muscosal-Associated Invariant T (MAIT) cells and antigen presentation by nonclassical or MHC-like proteins. Our strengths are in biochemistry, structural biology, protein engineering and cellular assays that will reveal the fundamental principles behind how effector cells of the immune system regulate human disease. We have a high level of expertise in studying molecular recognition of T cells, particularly unconventional T cells outside the canonical CD4+/CD8+ lineage and structure function of antigen-presenting molecules.
One or more keywords matched the following items that are connected to Adams, Erin J.
Item TypeName
Concept Antigen-Presenting Cells
Concept Receptors, Antigen, B-Cell
Concept HLA-A2 Antigen
Concept Receptors, Antigen, T-Cell, gamma-delta
Concept HLA-B8 Antigen
Concept Receptors, Antigen, T-Cell, alpha-beta
Concept Antigen Presentation
Concept Receptor-CD3 Complex, Antigen, T-Cell
Concept MART-1 Antigen
Concept HLA-B15 Antigen
Concept Receptors, Antigen, T-Cell
Concept Gene Rearrangement, gamma-Chain T-Cell Antigen Receptor
Concept HLA-A24 Antigen
Academic Article Inhibitor of DNA binding 3 limits development of murine slam-associated adaptor protein-dependent "innate" gammadelta T cells.
Academic Article The 2.5 Å structure of CD1c in complex with a mycobacterial lipid reveals an open groove ideally suited for diverse antigen presentation.
Academic Article ?d T cell receptors recognize the non-classical major histocompatibility complex (MHC) molecule T22 via conserved anchor residues in a MHC peptide-like fashion.
Academic Article The molecular basis for modulation of human V?9Vd2 T cell responses by CD277/butyrophilin-3 (BTN3A)-specific antibodies.
Academic Article The majority of CD1d-sulfatide-specific T cells in human blood use a semiinvariant Vd1 TCR.
Academic Article Expression of an unusual Bw4 epitope by a subtype of HLA-B8 [B*0802].
Academic Article Structure of an autoimmune T cell receptor complexed with class II peptide-MHC: insights into MHC bias and antigen specificity.
Academic Article Antigen recognition determinants of gammadelta T cell receptors.
Academic Article How the T cell receptor sees antigen--a structural view.
Academic Article High-level bacterial secretion of single-chain alphabeta T-cell receptors.
Academic Article Evidence that structural rearrangements and/or flexibility during TCR binding can contribute to T cell activation.
Academic Article Recognition of lyso-phospholipids by human natural killer T lymphocytes.
Academic Article An autonomous CDR3delta is sufficient for recognition of the nonclassical MHC class I molecules T10 and T22 by gammadelta T cells.
Academic Article Evolution of the V, D, and J gene segments used in the primate gammadelta T-cell receptor reveals a dichotomy of conservation and diversity.
Academic Article Key implication of CD277/butyrophilin-3 (BTN3A) in cellular stress sensing by a major human ?d T-cell subset.
Academic Article The yin and yang of CD1d recognition.
Academic Article CD1c tetramers detect ex vivo T cell responses to processed phosphomycoketide antigens.
Academic Article The molecular basis for Mucosal-Associated Invariant T cell recognition of MR1 proteins.
Academic Article Although divergent in residues of the peptide binding site, conserved chimpanzee Patr-AL and polymorphic human HLA-A*02 have overlapping peptide-binding repertoires.
Academic Article Lysophospholipid presentation by CD1d and recognition by a human Natural Killer T-cell receptor.
Academic Article The molecular basis for recognition of CD1d/a-galactosylceramide by a human non-Va24 T cell receptor.
Academic Article Structure of a gammadelta T cell receptor in complex with the nonclassical MHC T22.
Academic Article Diverse antigen presentation by the Group 1 CD1 molecule, CD1c.
Academic Article The adaptable major histocompatibility complex (MHC) fold: structure and function of nonclassical and MHC class I-like molecules.
Academic Article Molecular basis of mycobacterial lipid antigen presentation by CD1c and its recognition by aß T cells.
Academic Article The CD3 conformational change in the ?d T cell receptor is not triggered by antigens but can be enforced to enhance tumor killing.
Academic Article MAIT recognition of a stimulatory bacterial antigen bound to MR1.
Academic Article Lipid presentation by human CD1 molecules and the diverse T cell populations that respond to them.
Academic Article Crystal structure of Vd1 T cell receptor in complex with CD1d-sulfatide shows MHC-like recognition of a self-lipid by human ?d T cells.
Academic Article The intracellular B30.2 domain of butyrophilin 3A1 binds phosphoantigens to mediate activation of human V?9Vd2 T cells.
Academic Article The HLA-B73 antigen has a most unusual structure that defines a second lineage of HLA-B alleles.
Academic Article Introduction to Cellular Immunology Special Issue on ?d T cells.
Academic Article Human gamma delta T cells: Evolution and ligand recognition.
Academic Article Coevolution of T-cell receptors with MHC and non-MHC ligands.
Academic Article Molecular Analysis of Lipid-Reactive Vd1 ?d T Cells Identified by CD1c Tetramers.
Academic Article RhoB Mediates Phosphoantigen Recognition by V?9Vd2 T Cell Receptor.
Academic Article MR1-restricted mucosal-associated invariant T (MAIT) cells respond to mycobacterial vaccination and infection in nonhuman primates.
Academic Article The presence of HLA-A*2403 and HLA-B*1512 on the same haplotype in a Thai family.
Academic Article Human Leukocyte Antigen F Presents Peptides and Regulates Immunity through Interactions with NK Cell Receptors.
Academic Article V?9Vd2 T cell activation by strongly agonistic nucleotidic phosphoantigens.
Academic Article Phosphoantigen-induced conformational change of butyrophilin 3A1 (BTN3A1) and its implication on V?9Vd2 T cell activation.
Academic Article MR1 displays the microbial metabolome driving selective MR1-restricted T cell receptor usage.
Academic Article Generation and molecular recognition of melanoma-associated antigen-specific human ?d T cells.
Academic Article Casting a wider net: Immunosurveillance by nonclassical MHC molecules.
Academic Article TCR-pMHC bond conformation controls TCR ligand discrimination.
Academic Article Alpaca (Vicugna pacos), the first nonprimate species with a phosphoantigen-reactive V?9Vd2 T cell subset.
Academic Article Diversity in recognition and function of human ?d T cells.
Academic Article Molecular design of the ?dT cell receptor ectodomain encodes biologically fit ligand recognition in the absence of mechanosensing.
Academic Article The molecular characterization of antibody binding to a superantigen-like protein from a commensal microbe.
Academic Article Deaza-modification of MR1 ligands modulates recognition by MR1-restricted T cells.
Academic Article CRISPR screens decode cancer cell pathways that trigger ?d T cell detection.
Academic Article Multiple Isomers of Photolumazine V Bind MR1 and Differentially Activate MAIT Cells.
Academic Article Delivery of loaded MR1 monomer results in efficient ligand exchange to host MR1 and subsequent MR1T cell activation.
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