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Rebay, Ilaria
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overview The long-term goal of research in the Rebay Lab is to understand how signaling networks, cytoskeletal dynamics and tissue geometry work together to direct specific developmental decisions and programs. We use the developing Drosophila eye and heart as tractable model systems in which to explore how cell fates are specified and organized into functional tissues and organs. Our experimental approach is multidisciplinary, and incorporates molecular genetics, genomics, quantitative imaging, biochemistry and mathematical modeling. Current projects are focused on transcriptional networks and cellular mechanisms that regulate and stabilize the transition from uncommitted progenitor to specified fate and on signaling mechanisms and tissue-level biomechanical properties that together drive terminal differentiation and morphogenesis.
One or more keywords matched the following items that are connected to Rebay, Ilaria
Item TypeName
Concept Eye Proteins
Concept Eye Abnormalities
Concept Compound Eye, Arthropod
Concept Eye
Academic Article An activated Notch receptor blocks cell-fate commitment in the developing Drosophila eye.
Academic Article Eyes absent mediates cross-talk between retinal determination genes and the receptor tyrosine kinase signaling pathway.
Academic Article CRM1-mediated nuclear export and regulated activity of the Receptor Tyrosine Kinase antagonist YAN require specific interactions with MAE.
Academic Article Functional dissection of eyes absent reveals new modes of regulation within the retinal determination gene network.
Academic Article The novel plant homeodomain protein rhinoceros antagonizes Ras signaling in the Drosophila eye.
Academic Article Derepression by depolymerization; structural insights into the regulation of Yan by Mae.
Academic Article MAE, a dual regulator of the EGFR signaling pathway, is a target of the Ets transcription factors PNT and YAN.
Academic Article Using Drosophila to decipher how mutations associated with human branchio-oto-renal syndrome and optical defects compromise the protein tyrosine phosphatase and transcriptional functions of eyes absent.
Academic Article New vision from Eyes absent: transcription factors as enzymes.
Academic Article Targeting Drosophila eye development.
Academic Article The transcription factor Eyes absent is a protein tyrosine phosphatase.
Academic Article Identification of transcriptional targets of the dual-function transcription factor/phosphatase eyes absent.
Academic Article Interactions with the Abelson tyrosine kinase reveal compartmentalization of eyes absent function between nucleus and cytoplasm.
Academic Article Signal integration during development: mechanisms of EGFR and Notch pathway function and cross-talk.
Academic Article Sterile alpha motif domain-mediated self-association plays an essential role in modulating the activity of the Drosophila ETS family transcriptional repressor Yan.
Academic Article Modeling bistable cell-fate choices in the Drosophila eye: qualitative and quantitative perspectives.
Academic Article Split ends antagonizes the Notch and potentiates the EGFR signaling pathways during Drosophila eye development.
Academic Article The SAM domain of human TEL2 can abrogate transcriptional output from TEL1 (ETV-6) and ETS1/ETS2.
Academic Article Nemo phosphorylates Eyes absent and enhances output from the Eya-Sine oculis transcriptional complex during Drosophila retinal determination.
Academic Article Characterization of the split ends-like gene spenito reveals functional antagonism between SPOC family members during Drosophila eye development.
Academic Article Ras signal transduction pathway in Drosophila eye development.
Academic Article The eyes absent family of phosphotyrosine phosphatases: properties and roles in developmental regulation of transcription.
Academic Article The activities of two Ets-related transcription factors required for Drosophila eye development are modulated by the Ras/MAPK pathway.
Academic Article Yan functions as a general inhibitor of differentiation and is negatively regulated by activation of the Ras1/MAPK pathway.
Academic Article A genetic screen for novel components of the Ras/Mitogen-activated protein kinase signaling pathway that interact with the yan gene of Drosophila identifies split ends, a new RNA recognition motif-containing protein.
Academic Article Signal integration during development: insights from the Drosophila eye.
Academic Article New class of Son-of-sevenless (Sos) alleles highlights the complexities of Sos function.
Academic Article Function of the ETS transcription factor Yan in border cell migration.
Academic Article Chromatin occupancy patterns of the ETS repressor Yan: a mechanism for buffering gene expression against noise?
Academic Article The relationship between long-range chromatin occupancy and polymerization of the Drosophila ETS family transcriptional repressor Yan.
Academic Article Onset of atonal expression in Drosophila retinal progenitors involves redundant and synergistic contributions of Ey/Pax6 and So binding sites within two distant enhancers.
Academic Article 3D chromatin interactions organize Yan chromatin occupancy and repression at the even-skipped locus.
Academic Article A comparative study of Pointed and Yan expression reveals new complexity to the transcriptional networks downstream of receptor tyrosine kinase signaling.
Academic Article Long-range integration of repressive and patterning inputs.
Academic Article Dynamics and heterogeneity of a fate determinant during transition towards cell differentiation.
Academic Article Multiple Functions of the Eya Phosphotyrosine Phosphatase.
Academic Article Retinal Axon Guidance Requires Integration of Eya and the Jak/Stat Pathway into Phosphotyrosine-Based Signaling Circuitries in Drosophila.
Academic Article Drosophila Eye Nuclei Segmentation Based on Graph Cut and Convex Shape Prior.
Academic Article DNA Occupancy of Polymerizing Transcription Factors: A Chemical Model of the ETS Family Factor Yan.
Academic Article Antagonistic regulation of the second mitotic wave by Eyes absent-Sine oculis and Combgap coordinates proliferation and specification in the Drosophila retina.
Academic Article Pleiotropy in Drosophila organogenesis: Mechanistic insights from Combgap and the retinal determination gene network.
Academic Article Mutations that impair Eyes absent tyrosine phosphatase activity in vitro reduce robustness of retinal determination gene network output in Drosophila.
Academic Article Tuned polymerization of the transcription factor Yan limits off-DNA sequestration to confer context-specific repression.
Academic Article Cooperative recruitment of Yan via a high-affinity ETS supersite organizes repression to confer specificity and robustness to cardiac cell fate specification.
Academic Article Collaborative repressive action of the antagonistic ETS transcription factors Pointed and Yan fine-tunes gene expression to confer robustness in Drosophila.
Grant A systems-level study of signaling networks and differentiation
Academic Article Ratiometric sensing of Pnt and Yan transcription factor levels confers ultrasensitivity to photoreceptor fate transitions in Drosophila.
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