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Search Results to Michael A. Glotzer

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overview The Glotzer lab focuses on questions related to cell organization. How do cells coordinate the position of the contractile ring with the position of the spindle? By what mechanisms are cortical domains that mediate cell polarization assembled and maintained? How do cells regulate cortical contractility during developmental morphogenesis? To answer these questions, we use the nematode C. elegans, cultured human cells, budding yeast, and Drosophila as model systems and we combine forward and reverse genetics, biochemistry, and live cell imaging. Through these approaches we have discovered and extensively characterized the centralspindlin complex, a multifunctional protein complex that regulates essentially every step of cytokinesis. We have pioneered the use of optogenetics to dissect spatiotemporally regulated processes. Using these approaches, we have demonstrated that RhoA activation is sufficient to induce cleavage furrows irrespective of the position of the spindle or the stage of the cell cycle. Likewise, we obtained direct evidence that positive feedback is active during yeast cell polarization. By combining optogenetics with "conventional" genetics and live cell imaging we can directly test models for how cells endow well defined cortical regions with distinct properties that are required for complex cellular events, like cell division, cell polarization, and tissue scale morphogenetic events, such as gastrulation.

One or more keywords matched the following items that are connected to Glotzer, Michael A.

Item TypeName
Concept Cell Cycle
Concept Cell Cycle Proteins
Academic Article Kleisins: a superfamily of bacterial and eukaryotic SMC protein partners.
Academic Article Comparative analysis of cytokinesis in budding yeast, fission yeast and animal cells.
Academic Article Cytokinesis: progress on all fronts.
Academic Article Cell cycle regulation of central spindle assembly.
Academic Article Polo-like kinase 1 triggers the initiation of cytokinesis in human cells by promoting recruitment of the RhoGEF Ect2 to the central spindle.
Academic Article An ECT2-centralspindlin complex regulates the localization and function of RhoA.
Academic Article Clustering of centralspindlin is essential for its accumulation to the central spindle and the midbody.
Academic Article The molecular requirements for cytokinesis.
Academic Article Cooperative assembly of CYK-4/MgcRacGAP and ZEN-4/MKLP1 to form the centralspindlin complex.
Academic Article Polo-like kinase 1 directs assembly of the HsCyk-4 RhoGAP/Ect2 RhoGEF complex to initiate cleavage furrow formation.
Academic Article The CeCDC-14 phosphatase is required for cytokinesis in the Caenorhabditis elegans embryo.
Academic Article CSC-1: a subunit of the Aurora B kinase complex that binds to the survivin-like protein BIR-1 and the incenp-like protein ICP-1.
Academic Article Local RhoA activation induces cytokinetic furrows independent of spindle position and cell cycle stage.
Academic Article Cell cycle entry triggers a switch between two modes of Cdc42 activation during yeast polarization.
Academic Article Cytokinesis.
Academic Article Chromosome segregation: Samurai separation of Siamese sisters.
Academic Article Separase is required for chromosome segregation during meiosis I in Caenorhabditis elegans.
Academic Article Cell polarity. The importance of being polar.
Academic Article Cell cycle. The only way out of mitosis.
Academic Article Incenp and an aurora-like kinase form a complex essential for chromosome segregation and efficient completion of cytokinesis.
Academic Article A requirement for Rho and Cdc42 during cytokinesis in Xenopus embryos.
Academic Article PLK1 plays dual roles in centralspindlin regulation during cytokinesis.

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