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One or more keywords matched the following properties of Glotzer, Michael A.
keywords Cytokinesis
overview The Glotzer lab focuses on questions related to cell organization. How do cells coordinate the position of the contractile ring with the position of the spindle? By what mechanisms are cortical domains that mediate cell polarization assembled and maintained? How do cells regulate cortical contractility during developmental morphogenesis? To answer these questions, we use the nematode C. elegans, cultured human cells, budding yeast, and Drosophila as model systems and we combine forward and reverse genetics, biochemistry, and live cell imaging. Through these approaches we have discovered and extensively characterized the centralspindlin complex, a multifunctional protein complex that regulates essentially every step of cytokinesis. We have pioneered the use of optogenetics to dissect spatiotemporally regulated processes. Using these approaches, we have demonstrated that RhoA activation is sufficient to induce cleavage furrows irrespective of the position of the spindle or the stage of the cell cycle. Likewise, we obtained direct evidence that positive feedback is active during yeast cell polarization. By combining optogenetics with "conventional" genetics and live cell imaging we can directly test models for how cells endow well defined cortical regions with distinct properties that are required for complex cellular events, like cell division, cell polarization, and tissue scale morphogenetic events, such as gastrulation.
One or more keywords matched the following items that are connected to Glotzer, Michael A.
Item TypeName
Academic Article Cytokinesis: regulated by destruction.
Academic Article Central spindle assembly and cytokinesis require a kinesin-like protein/RhoGAP complex with microtubule bundling activity.
Academic Article Comparative analysis of cytokinesis in budding yeast, fission yeast and animal cells.
Academic Article Cytokinesis: progress on all fronts.
Academic Article Cytokinesis: a logical GAP.
Academic Article Polo-like kinase 1 triggers the initiation of cytokinesis in human cells by promoting recruitment of the RhoGEF Ect2 to the central spindle.
Academic Article Developmental regulation of central spindle assembly and cytokinesis during vertebrate embryogenesis.
Academic Article Control of cortical contractility during cytokinesis.
Academic Article Cytokinesis: GAP gap.
Academic Article Sequential Cyk-4 binding to ECT2 and FIP3 regulates cleavage furrow ingression and abscission during cytokinesis.
Academic Article An ECT2-centralspindlin complex regulates the localization and function of RhoA.
Academic Article Regulation of cortical contractility and spindle positioning by the protein phosphatase 6 PPH-6 in one-cell stage C. elegans embryos.
Academic Article Controlling cytokinesis through promiscuous phosphorylation outside BARs.
Academic Article Cytokinesis: integrating signaling, the cytoskeleton, and membranes to create new daughter cells.
Academic Article Single cells (put a ring on it).
Academic Article RhoA activation during polarization and cytokinesis of the early Caenorhabditis elegans embryo is differentially dependent on NOP-1 and CYK-4.
Academic Article Centralspindlin: at the heart of cytokinesis.
Academic Article The RhoGAP domain of CYK-4 has an essential role in RhoA activation.
Academic Article The molecular requirements for cytokinesis.
Academic Article Phosphorylation of ZEN-4/MKLP1 by aurora B regulates completion of cytokinesis.
Academic Article Cytokinesis: welcome to the Rho zone.
Academic Article The CeCDC-14 phosphatase is required for cytokinesis in the Caenorhabditis elegans embryo.
Academic Article Astral signals spatially bias cortical myosin recruitment to break symmetry and promote cytokinesis.
Academic Article Anillin is a scaffold protein that links RhoA, actin, and myosin during cytokinesis.
Academic Article Cytokinesis: centralspindlin moonlights as a membrane anchor.
Academic Article Aurora B kinase promotes cytokinesis by inducing centralspindlin oligomers that associate with the plasma membrane.
Academic Article The RhoGAP activity of CYK-4/MgcRacGAP functions non-canonically by promoting RhoA activation during cytokinesis.
Academic Article Cytokinesis: Placing the Furrow in Context.
Academic Article Local RhoA activation induces cytokinetic furrows independent of spindle position and cell cycle stage.
Academic Article Cytokinesis in Metazoa and Fungi.
Academic Article Spatiotemporal Regulation of RhoA during Cytokinesis.
Grant Spatial and temporal control of Rho family GTPases
Grant Positioning the Plane of Cell Division During Cytokinesis
Grant Molecular Dissection of Cytokinesis
Academic Article Animal cell cytokinesis.
Academic Article Cytokinesis.
Academic Article Depletion of syntaxins in the early Caenorhabditis elegans embryo reveals a role for membrane fusion events in cytokinesis.
Academic Article CDK1 inactivation regulates anaphase spindle dynamics and cytokinesis in vivo.
Academic Article The mechanism and control of cytokinesis.
Academic Article Incenp and an aurora-like kinase form a complex essential for chromosome segregation and efficient completion of cytokinesis.
Academic Article CYK-4: A Rho family gtpase activating protein (GAP) required for central spindle formation and cytokinesis.
Academic Article A requirement for Rho and Cdc42 during cytokinesis in Xenopus embryos.
Academic Article PLK1 plays dual roles in centralspindlin regulation during cytokinesis.
Academic Article Cortical recruitment of centralspindlin and RhoA effectors during meiosis I of Caenorhabditiselegans primary spermatocytes.
Academic Article Aurora A and cortical flows promote polarization and cytokinesis by inducing asymmetric ECT-2 accumulation.
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