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The CoREST/REST repressor is both necessary and inimical for expression of herpes simplex virus genes.
Disruption of HDAC/CoREST/REST repressor by dnREST reduces genome silencing and increases virulence of herpes simplex virus.
HSV carrying WT REST establishes latency but reactivates only if the synthesis of REST is suppressed.
The role of the CoREST/REST repressor complex in herpes simplex virus 1 productive infection and in latency.