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Grdina, David

One or more keywords matched the following properties of Grdina, David

Property	Value
keywords	Adaptive Responses, Genomic Instability, Radioprotectors, Amifostine, Radiation Biology

One or more keywords matched the following items that are connected to Grdina, David

Item Type	Name
Concept	Amifostine
Academic Article	Antimutagenic effects of amifostine: clinical implications.
Academic Article	Chemopreventive doses of amifostine confer no cytoprotection to tumor nodules growing in the lungs of mice treated with cyclophosphamide.
Academic Article	WR-1065, an active metabolite of the cytoprotector amifostine, affects phosphorylation of topoisomerase II alpha leading to changes in enzyme activity and cell cycle progression in CHO AA8 cells.
Academic Article	Repression of c-myc gene expression by the thiol and disulfide forms of the cytoprotector amifostine.
Academic Article	Misoprostol, a PGE1 analog, protects mice from fission-neutron injury.
Academic Article	Protection against late effects of radiation by S-2-(3-aminopropylamino)-ethylphosphorothioic acid.
Academic Article	Cytoprotection by WR-1065, the active form of amifostine, is independent of p53 status in human malignant glioma cell lines.
Academic Article	Amifostine: mechanisms of action underlying cytoprotection and chemoprevention.
Academic Article	Activation of the nuclear transcription factor kappaB (NFkappaB) and differential gene expression in U87 glioma cells after exposure to the cytoprotector amifostine.
Academic Article	Delayed cytoprotection after enhancement of Sod2 (MnSOD) gene expression in SA-NH mouse sarcoma cells exposed to WR-1065, the active metabolite of amifostine.
Academic Article	Differential activation of nuclear transcription factor kappaB, gene expression, and proteins by amifostine's free thiol in human microvascular endothelial and glioma cells.
Academic Article	Inhibition of spontaneous metastases formation by amifostine.
Academic Article	Antimetastatic effectiveness of amifostine therapy following surgical removal of Sa-NH tumors in mice.
Academic Article	Radioprotectants: current status and new directions.
Academic Article	Relationships between cytoprotection and mutation prevention by WR-1065.
Academic Article	Oral administration is as effective as intraperitoneal administration of amifostine in decreasing nitroxide EPR signal decay in vivo.
Academic Article	Interaction of amifostine and ionizing radiation on transcriptional patterns of apoptotic genes expressed in human microvascular endothelial cells (HMEC).
Academic Article	Manganese superoxide dismutase (SOD2)-mediated delayed radioprotection induced by the free thiol form of amifostine and tumor necrosis factor alpha.
Academic Article	Incidence of tissue toxicities in gamma ray and fission neutron-exposed mice treated with Amifostine.
Academic Article	Delayed radioprotection by NFkappaB-mediated induction of Sod2 (MnSOD) in SA-NH tumor cells after exposure to clinically used thiol-containing drugs.
Academic Article	WR-1065, the active metabolite of amifostine, mitigates radiation-induced delayed genomic instability.
Academic Article	Amifostine reduces lung vascular permeability via suppression of inflammatory signalling.
Academic Article	Maintenance of manganese superoxide dismutase (SOD2)-mediated delayed radioprotection induced by repeated administration of the free thiol form of amifostine.
Academic Article	Amifostine metabolite WR-1065 disrupts homologous recombination in mammalian cells.
Academic Article	Relationship between phosphorylated histone H2AX formation and cell survival in human microvascular endothelial cells (HMEC) as a function of ionizing radiation exposure in the presence or absence of thiol-containing drugs.
Academic Article	Protective effect of S-2-(3-aminopropylamino)ethylphosphorothioic acid against induction of altered hepatocyte foci in rats treated once with gamma-radiation within one day after birth.
Academic Article	SOD2-mediated adaptive responses induced by low-dose ionizing radiation via TNF signaling and amifostine.
Academic Article	Radioprotectors in treatment therapy to reduce risk in secondary tumor induction.
Academic Article	Radiation-induced DNA single-strand breaks in the intestinal mucosal cells of mice treated with the radioprotectors WR-2721 or 16-16 dimethyl prostaglandin E2.
Academic Article	The radioprotector WR-2721 reduces neutron-induced mutations at the hypoxanthine-guanine phosphoribosyl transferase locus in mouse splenocytes when administered prior to or following irradiation.
Academic Article	In vivo protection by the aminothiol WR-2721 against neutron-induced carcinogenesis.
Academic Article	Thiol and disulfide metabolites of the radiation protector and potential chemopreventive agent WR-2721 are linked to both its anti-cytotoxic and anti-mutagenic mechanisms of action.
Academic Article	Amifostine induces antioxidant enzymatic activities in normal tissues and a transplantable tumor that can affect radiation response.
Academic Article	A comparison of radioprotection from three neutron sources and 60Co by WR-2721 and WR-151327.
Academic Article	Protection by WR-2721 and WR-151327 against late effects of gamma rays and neutrons.
Academic Article	Induction of cellular antioxidant defense by amifostine improves ventilator-induced lung injury.
Academic Article	Antimutagenic effects of radioprotector WR-2721 against fission-spectrum neurons and 60Co gamma-rays in mice.
Academic Article	Protection from radiation-induced apoptosis by the radioprotector amifostine (WR-2721) is radiation dose dependent.
Academic Article	Metformin exhibits radiation countermeasures efficacy when used alone or in combination with sulfhydryl containing drugs.
Grant	Delayed Radioprotection by Thiols
Grant	EXPERIMENTAL RADIOTHERAPY--CARCINOGENESIS, AND PROTECTOR
Grant	Radiation Protectors and Radiation Therapy Coupled Chemoprevention

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Amifostine